The study sought to assess to assess the policy guidelines, strategies, and operational processes associated with plastic waste management in Ghana. A descriptive cross-sectional study design that employed both quantitative and qualitative procedures was used. The data was analysed using Statistical Package for Social Sciences (SPSS). Descriptive analysis was performed on the structured questionnaire whereas thematic analysis was conducted on data from the interview guided. The results revealed that there are guidelines, strategies, and operational processes for plastic waste management in greater Kumasi and there exist different activities of stakeholders (Recycling companies, KMA and Waste collectors) in plastic waste management in Kumasi. The extent of compliance with plastic waste management guidelines (National Plastic Waste Management Policy) is dependent on the different stakeholders. Plastic recycling companies are in the infant stage with their activities being centered on six processes with pelletizing plastics for export been their major activities whereas waste collectors are solely responsible for collection, transportation and final disposal of plastic waste from different places to either dump sites or plastic recycling companies. KMA and other government institutions involved in waste management must take steps by supervising the day-to-day activities of plastic recycling companies and waste collectors to regulate the activities of companies within the plastic recycling industry.