IntroductionMedical students generally are known to have low quality of life due to the challenging academic load and the stressful environment. However, exploring medical students' quality of life in war zones, like Yemen, where social, political and economic instability, can impact their quality of life is of great value. The prime objective of this study was to examine various factors that can influence the quality of life among medical students in Hadramout, Yemen.MethodsA validated Arabic version of the WHOQOL‐BREF questionnaire with additional demographic and basic life support inquiries was used to collect data. Mann Whitney U and Kruskal‐Wallis tests were used to determine the difference between groups.ResultsA total of 416 responses were included in the analysis. Alarmingly, 10%, 61%, and 33.4% of the students did not have basic life supports of water, electricity and sewage treatment, respectively (P values<0.05). Male students scored higher than females in physical (P=0.013), psychological (p=0.02) and social domains (P<0.001). While the overall quality of life was low, major factors that contributed to better quality of life were: Environment‐wise being married or single compared to divorced (P=0.007, P=0.01, respectively); overall, living in a town compared to countryside (P=0.01); being healthy compared to having an illness in overall score and individual domains (P<0.01); living in family owned or rented house compared to dorms in the environmental domain (P<0.001, P=0.006, respectively); and having a good relation with one's parents in physical (P=.003), psychological (P=0.001), social (0.02), and the overall score (P=0.001) compared to poor relationship.ConclusionSocial and economic factors that were exacerbated by the current war in Yemen have significantly contributed to low quality of life among Yemeni medical students. Prompt, yet strategic steps should be taken by the national and international organizations to rescue the academic and social life of medical students' in Yemen by providing basic academic and social life support for students.Support or Funding InformationWe would like to thank Hadramout University, faculty and students for their support and help in completing this study. Special thanks and appreciation to our 4th year colleagues from Hadramout University, College of medicine: 1) Muhammed Salah Al‐Qu'aiti, 2) Abdullah Salem Bahadi, 3) Ashraf Fahed Basalelah.