Three-dimensionally ordered macroporous (3DOM) LaMnAl11O19 and xAuPdy/3DOM LaMnAl11O19 (x=0.44−1.91wt%; y=1.80−1.86) were prepared via the polymethyl methacrylate (PMMA)-templating and gas bubble-assisted polyvinyl alcohol (PVA)-protected reduction routes, respectively. Physicochemical properties of the samples were characterized by a number of analytical techniques. Catalytic activities of the samples were measured for methane combustion in a continuous-flow microreactor. It is shown that the LaMnAl11O19 in each of the samples was hexagonal in crystal structure, and all of the samples possessed a good-quality 3DOM architecture with a surface area of 24.4−28.2m2/g. The Au–Pd nanoparticles (NPs) with an average size of 2.8nm were uniformly dispersed on the macropore walls of 3DOM LaMnAl11O19. The 1.91AuPd1.80/3DOM LaMnAl11O19 sample performed the best for methane combustion (T50%=342°C and T90%=402°C at a space velocity of 20,000mL/(gh)). The deactivation of the 1.91AuPd1.80/3DOM LaMnAl11O19 catalyst induced by water vapor introduction was reversible, whereas that induced by SO2 addition was irreversible. It is concluded that the good catalytic activity of 1.91AuPd1.80/3DOM LaMnAl11O19 was related to its good-quality 3DOM structure, highly dispersed Au–Pd NPs, high adsorbed oxygen species concentration, good low-temperature reducibility, and strong interaction between Au–Pd alloy NPs and 3DOM LaMnAl11O19.