Several research studies have identified window-wall interfaces as one of the major sources of water ingress through building envelopes. Window-wall interfaces can either be sealed by means of face-sealed or drained sealing systems. In general, it is assumed that drained window-wall interfaces show an improved rainwater resistance compared to face-sealed interfaces. However, only a limited number of studies can be found in literature evaluating the watertightness performance of both face-sealed and drained window-wall interfaces. The objective of this paper is to evaluate the performance of both face-sealed and drained sealing methods and to identify the primary factors affecting the water resistance of window-wall interfaces.Various combinations of exterior seal, drainage layer, air barrier, airtightness level, installation method and wall assemblies were assessed by means of 5 face-sealed test specimens and 9 drained specimens. Both static and cyclic tests were performed. It was found that both tests showed corresponding results with regard to the pressure threshold value for water ingress. The results in this study also indicated that the airtightness of the interfaces and the presence of a separate air barrier at the interior side of the interface affected the watertightness performance to a great extent. The findings showed that it is very difficult to obtain water resistant face-sealed window-wall interfaces, even in lab conditions. It is therefore recommended to always provide drainage possibilities behind the exterior seal or cladding.