Vulvovaginitis In Girls Research Articles

CAUSES AND CONSEQUENCES OF VULVOVAGINITIS AND CHILDREN'S MASTURBATION

Conducted examinations of girls aged 2-11 with vulvovaginitis accompanying childhood masturbation(primary and recurrent). Due to the ineffectiveness of traditional anti-inflammatory therapy proposed a comprehensive method of treatment, which considering neurological and gynecological conditions. It was marked a noticeable therapeutic effect thereby the authors propose to optimize the treatment of vulvovaginitis in girls which suffering from childhood masturbation.

Helminth Infections in Children.

Helminth Infections in Children.

Determination of somatic status of girls with chronic vulvovaginitis in the neutral period of life

The objective: a determination of the spread of somatic pathology and polymorphism of the MSM6 gene in the development of chronic recurrent vulvovaginitis in girls. Materials and methods. The study involved 54 girls 1–6 years old. Inclusion criteria: complaints of patients on itching or pain in the genital area, dysuria, the presence of synechiae of the vulva, clinical manifestations of vulvitis during the visual examination. General laboratory diagnostic methods were used (blood test, general urine analysis with determination of ketone bodies, bacterioscopic examination of vaginal smears, vaginal culture for flora and antibiotic sensitivity, determination of glucose levels in blood serum and urine). For diagnosis of lactose malabsorption by polymerase chain reaction, a mutation in the MCM6 gene was studied, the genetic marker of which is C (-13910). Results. The somatic status of patients with chronic vulvovaginitis was presented by pathology of the gastrointestinal digestive tract in 68.5 % cases, atopic dermatitis – 53.7 %, diseases of the respiratory system – 33.3 %, infectious processes of the kidneys and urinary tract – 24.1 %. 77.6 % of girls had nondiabetic acetone syndrome, 75.9 % – dysmetabolic nephropathy. The presence of lactose malabsorption was revealed by homozygosity for the MCM6 gene mutation (C/C) in 26.1% of patients, heterozygosity for the MCM6 gene mutation (C/T) - in 56.5 %, the absence of the MCM6 gene mutation (T/T) was in 8 (17.4 %). Conclusions. In girls in the neutral period of life with chronic vulvovaginitis, non-infectious forms of the disease were found, which were not independent pathology, but associated with other pathological processes of metabolic disorders. Taking into account the obtained data on lactose malabsorption, we consider to include in the examination the algorithm of the verification of the MCM6 gene mutation and examination of urine for lactosuria and blood with lactose load.

Features of comorbid symptoms in vulvovaginitis in girls with urinary tract infections

Background . Urinary tract infections are the most common nephrological diseases in girls. Currently, there is a need to develop comprehensive interdisciplinary approaches to the examination of patients with vulvovaginitis against the background of pre-school urinary tract infection. The aim: to study the characteristics of comorbid symptoms of vulvovaginitis in girls of pre-school age suffering from urinary tract infections. PATIENTS AND METHODS. A prospective controlled study was conducted in 107 girls aged 3-6 years, including: group 1 (n=45) - patients with vulvovaginitis against a background of recurrent urinary tract infection; group 2 (n=32) - patients with an isolated form of vulvovaginitis; group 3(n=30) - girls of 1, 2 health groups. A specialized gynecological examination was performed. Statistical processing was performed using the application program "SPSS Statistics 17.0 for Windows". Results. Revealed that patients with concomitant vulvovaginitis compared to patients with isolated vulvovaginitis, often marked by painful urination, discomfort in the genital area, serous (35.7 %) and mucopurulent (55,6 %) vaginal discharge, petechial rash, anatomical (prolapse of the urethra, close proximity of the meatus to the entrance of the vagina) and inflammatory changes (edema, hyperemia) in the region of the urethra, high frequency fringed structure of the hymen (p=0,12). Diffuse hyperemia in the vulva area was more often observed in patients with isolated vulvovaginitis. Conclusions. Patients with vulvovaginitis and recurrent recurrent urinary tract infection have a burdened social and biological history. In dispensary management, an interdisciplinary approach is required, taking into account the identified medical and social risk factors.

Medical and social risk factors for recurrent vulvovaginitis in girls with urinarysystem infections

BACKGROUND. The leading role in the development of vulvovaginitis in girls of pre-school age belongs to the extragenital diseases, including recurrent urinary tract infections. The study of medical and social factors that affect the development of reproductive health disorders is of urgent importance. THE AIM: to study the medical and social risk factors for recurrent vul­vovaginitis in preschool girls suffering from urinary tract infections. PATIENTS AND METHODS. A prospective controlled study was conducted in 107 girls aged 3-6 years, including group 1 (n=45) - patients with vulvovaginitis against the background of recurrent uncomplicated urinary tract infection; group 2 (n=32) - patientswith an isolated form of vulvovaginitis; group 3(n=30) - girls of health groups 1 and 2. The main parameters of social and biological anamnesis are analyzed. Statistical analysis was performed using the program "SPSS Statistics V. 17.0" ("SPSS Inc. IBM Company", USA). RESULTS. Patients with a combined form of vulvovaginitis, in comparison with patients with isolated vulvovaginitis, more often lived in rural areas, were from large families, belonged to the group of preschool children who do not attend preschool educational institutions, in their families, the monetary income was lower than the subsistence minimum (p<0.001). The lowest level of hygiene was observed in pa­tientswith isolated forms of vulvovaginitis. In patientswith combined forms of vulvovaginitis, in comparison with patientswith isolated vulvovaginitis, gestational complications were significantly higher: 22.2% had gestational pyelonephritis, 13.6% had a premature birth, and 22.2% had a cesarean section (p <0.05). CONCLUSION. Patients with vulvovaginitis and recurrent UTI have a burdened social and biological history. In dispensary management, an interdisciplinary approach is required, taking into account the identified medical and social risk factors.

Prediction of bacterial vulvovaginitis in girls at different Tanner stages of sexual development

At present, there is a paucity of research studies that comprehensively investigate the factors causing vulvovaginitis in young females. The aim of this work was to propose an algorithm for predicting the risk of vulvovaginitis in young girls and adolescents. The study recruited 252 healthy girls, who were stratified into a few groups depending on their sexual development on the Tanner scale. The composition of vaginal microbiota was determined in all the participants using real-time polymerase chain reaction (PCR); distribution of allele and genotype frequencies was assessed for the polymorphic variants of genes coding for pro- and anti-inflammatory cytokines. Based on the obtained data, we created a functional model for predicting the risk of vulvovaginitis in girls at different stages of sexual development. Favorable risk factors for Tanner I girls included predominance of obligate anaerobes in vaginal microbiota and the polymorphic IL10 variant (C-819T) homozygous for TT. The sensitivity of the model was 80%, its specificity was 78%. Favorable risk factors for prepubertal and pubertal girls included predominance of aerobes in the composition of vaginal microbiota and the presence of the TT allele in the polymorphic IL10 gene variant (C-3953T). The sensitivity of the model was 58.3%, whereas specificity, 94.1%. This study provides the rationale conforming with the principles of evidence-based medicine for using prevention measures in the groups at risk for vulvovaginitis at young age. The proposed measures allowed us to reduce the relapse rate of bacterial vulvovaginitis threefold.

Candidal vulvovaginitis in girls: clotrimazole as the drug of choice

The article presents the results of a study on the effectiveness of using clotrimazole 2% to treat candidal vulvovaginitis in girls. The use of a clotrimazole 2% cream treatment regimen, (100 mg), intravaginally once daily in girls with candidal vulvovaginitis is justified and highly effective. The absence of side effects while taking clotrimazole increases the commitment to this type of therapy.

To the question of vagina dysbiosis in girls with urinary tract infections

Currently, girls with urinary tract infection (UTI) have a high incidence of chronic vulvovaginitis. The aim : to study the state of the vaginal biotope in girls of preschool age with urinary tract infections. Patients and methods . A prospective controlled randomized study was conducted in 88 girls aged 3-6 years with UTI, of whom 1 group (n = 36) with rare UTI (no more than 3 times a year); group 2 (n = 32) - with frequent recurrences of UTI (more than 3 times a year). The control group consisted of 20 girls of similar age without a UTI in the anamnesis. Vaginal microbiocenosis was assessed by bacterioscopic, bacteriologically and by using quantitative polymerase chain reaction (PCR). Results. In patients with frequent recurrences of UTI, chronic vulvovaginitis was detected significantly more often than in rare relapses. In patients with frequent UTI with a vaginal smear microscopy, in all cases there was a leukocyte reaction (more than 15 leukocytes in the field of view). Leukocytes had a neutrophilic character. When crops were significantly more frequent than in the control and 1st group, the presence of Esherichia coli was noted. According to the results of quantitative PCR, a large number of facultative aerobes were noted with abundant growth (> 10 5 CFU / ml). Interferon effectiveness was pathogenetically justified in combined urogenital infections. Conclusion . UTIs make a significant contribution to the development of dysbiosis of the vaginal biotope in preschool girls in the form of the prevalence of gram-negative aerobic microflora. Correction of chronic vulvovaginitis in girls with UTI should be complex, improvement is achieved using interferon.

PREDIOTION OF INFLAMMATORY DISEASES OF THE VULVA AND VAGINA IN GIRLS DEPENDING ON THE STAGE OF SEXUAL DEVELOPMENT

The article is devoted to current views on risk factors of the vulvovaginitis in girls and the possibility of its prognosis. Survey findings on hygienic skills, the anamnesis, findings of vaginal microbiota of girls and polymorphism of genes of the immune response are provided in the article. Received data allowed to create multidimensional predictive models of risk of vulvovaginitis development in girls depending on the stage of sexual maturation introduced by Tanner.

Особенности оценки клинической эффективности лечения вульвовагинитов у девочек (клинический случай)

Особенности оценки клинической эффективности лечения вульвовагинитов у девочек (клинический случай)

Wybrane problemy dermatologiczno-ginekologiczne z uwzględnieniem niektórych aspektów dietetycznych u dziewcząt

Dermatological-gynaecological problems in girls are an important issue also in the practice of a family doctor. In the case of girls before menarche, vulvovaginal inflammation accounts for 75% of all gynaecology reports. However, there is a need to differentiate inflammatory diseases of the vulva from dermatoses. Symptoms of vulval diseases, which are reported by patients, often require consultation and dermatological treatment. Since dermatoses are not limited to genitals, the vulva is only one of possible locations of the disease process; therefore, the whole skin of the patient should be inspected. Vaginal and vaginal inflammation is a gynaecological problem in patients of all ages ? from neonatal period to old age. In developmental age gynaecology, it is often found in 3-10-year-old patients. The etiopathogenesis of vulvovaginitis in girls depends on child's age, systemic diseases, and often dermatological problems. For example, such factors as diabetes, long-term antibiotic therapy, immunosuppression, congenital immunodeficiency, allergic diseases and allergic rhinitis predispose to infections in girls. Lactobacillus plays an important role in bacterial protection against infection and inflammation. A balanced diet is also important.

Interdisciplinary approach to solving the problem of bacterial vulvovaginitis in girls with urinary tract infections

In order to improve the diagnosis and treatment of bacterial vulvovaginitis (VV) in preschool children with urinary tract diseases, we conducted the prospective controlled study of 86 patients aged 3–6 years, of which: group 1 (n = 21) – VV; group 2 (n = 20) – VV against the background of chronic pyelonephritis with exacerbation; group 3 (n = 20) – VV against the background of acute pyelonephritis; group 4 (n = 25) – VV with dismetabolic nephropathy. Depending on the method of correction, the patients were divided into those that received standard treatment and those that received combined treatment with the use of a bacteriophage complex. It was revealed that chronic forms of VV prevailed in all groups, but when combined with urinary tract diseases (groups 2, 3, 4), the incidence of synechia of the labia minora was significantly increased. It was established that the number of relapses of VV after the combined treatment is significantly lower than after the standard treatment.Inflammatory urogenital diseases in girls are characterized by a high rate of relapse. The combination therapy of VV, including the use of a bacteriophage complex, improves the condition of the vaginal biotope, prevents the persistence of the infection.

Clinical presentation, diagnosis and treatment of vulvovaginitis in girls: a current approach and review of the literature.

Vulvovaginitis is the most common cause of gynecological complaints in children and young girls. Some of the factors which cause vulvovaginitis include hypoestrogenism, the anatomical proximity of rectum and delicate vulvar skin and vaginal mucosa. We made a literature search with Pubmed, Medline and Cochrane database from January 2002 to May 2015 in English language using the key words vulvovaginitis, children, clinical, diagnosis and treatment. Vulvovaginitis in girls is usually caused by non-specific factors and hygiene measures, bioyoghurt and avoidance of chemical irritants are generally useful. Weight control if necessary and prevention of voiding dysfunction are effective. Vaginal flora is important in girls and results should be interpreted with clinical features to decide whether an isolated microorganism is part of the normal microflora or is the cause of symptomatic vulvovaginitis. Specific treatment is generally considered in case of a detected pathogen microorganism. Isolation of a sexually transmitted organism requires further investigation. Persistent disease may not always indicate a foreign body but it must be taken into account. Girls and parents are encouraged psychologically in all steps of evaluation, diagnosis and treatment. Probiotics, nanotechnology and petroleum jelly are other important treatment options used in vulvovaginitis. In this review, we present current approach to the presentation and management of vulvovaginitis in childhood. This disorder requires a comprehensive evaluation in all steps of diagnosis, differential diagnosis and treatment.

Humoral fact mucosal innate and adaptive immunity of the vaginal mucosa in girls puberty vulvovaginal

Inflammation the external genitals takes first place in the structure gynecological diseases girls and young women. The frequency vulvovaginitis according to different authors range from 12 to 93%, and 60% disease is recurrent in nature. In the evolution the doctrine immunity was an allocation of the immune system mucous membranes the overall immune system. Mucosa has all types immune cells (lymphocytes, leukocytes, monocytes, macrophages, etc.) required for generating an immune response. Objective . Improved diagnostic techniques, in order to optimize the treatment vaginitis, and the girls to preserve the reproductive potential in the future. The objectives the study . Identify the features humoral, cellular, local immunity, pro- and anti-cytokine status girls suffering from vulvovaginitis. Methods : immunological and statistical. Results and discussion . It is shown that the development vulvovaginitis in girls' puberty accompanied by an increase in the content vulvovaginal lysozyme activity at 67.80%, which confirms the presence antigen (germ) stimulating factors and mechanisms nonspecific anti-infectious protection (natural immunity) the vaginal mucosa in girls puberty with vulvovaginitis.. Also increases the concentration secretory IgA at 76.06%, which is a testament not only to the activation non-specific factors and mechanisms anti-infectious defense, and formed specific mechanisms reactivity vaginal mucosa in these patients. It is shown that girls in puberty with vulvovaginitis significantly increases the concentration preimmune and immune cytokines is an indication the presence antigenic stimulation (microbial contamination) and increased activation factors and mechanisms as a nonspecific anti-infectious protection and adequate specific immune response by increasing the regulatory function preimmune and immune cytokines. It increased by 16.67% the amount TNF-α, which is considered one the key regulators the innate reactivity, along with IL-1β, and interferon α and β. Main cells secreting TNF-α, are monocytes / macrophages and natural killer cells. TNF-α is a major mediator host cells, which is synthesized in response to the contamination pathogenic Gram-negative bacteria (lipopolysaccharide). An increase 81.17% concentration IL-1β, the main mediator inflammatory processes with multifunctional role indicates activation IL-2 production, which causes hepato-cytokines production acute phase protein; increase the activity protective features the inflammatory response. The concentration IL-6 multipurpose increased by 49.28%, indicating that the girls puberty with vulvovaginitis, enhanced the differentiation B-lymphocytes and immunoglobulin production all classes and production acute phase proteins. Increase by 21.13% immune inflammatory IL-10 is an indication the suppressive effect on the formation a specific immune response, inhibition production proinflammatory cytokines by T helper type I (Th-1), which improves the efficiency the cellular immune response. Conclusion . The above indicates that the development vulvovaginitis in girls' puberty is accompanied by the activation factors and mechanisms non-specific and specific immune anti-infection as a systemic and local security. This activates the regulatory function preimmune (first generation) and immune (second generation) cytokines in peripheral blood, as well as increased non-specific protective function (lysozyme) and specific immune (secretory immunoglobulin A (sIgA) humoral factors secretory contents the vagina.

A Bacteriologic Study of Vulvovaginitis of Children

Vulvovaginitis in girls of school age leads to exclusion from school and to economic waste on other accounts. The treatment of the condition in the homes of the poor and in the dispensary is unsatisfactory and prolonged. In girls of pre-school age it necessitates frequent visits to the dispensary, with a consequent loss of time for the mother or other adult member of the family who must accompany the child, before the latter can be considered free of infection and no longer a source of danger to others. If the cases are hospitalized, the economic loss is again great. Isolation and exclusion from school are based on the belief that the infection is gonorrheal. For some of the institutional epidemics the specific character of the process has been established, but that all patients with vulvovaginitis reporting to dispensaries for treatment are of similar etiology appeared to require further investigation. There may be some question as to the necessity for isolation and exclusion from school of cases not due to the gonococcus, if such cases occur. Nonspecific cases also may possibly require a different method of treatment, or may yield more readily to the same kind of treatment, which is found most efficacious against the gonorrheal variety.