Vulvar Leiomyoma Research Articles

Septic shock following cervical cerclage for advanced cervical dilatation

had wide local excision and one vulvectomy. Four recurrences occurred. The vulvectomy and two of the three local excisions (one unstated) did not recur. Recurrence can occur as late as 11 years after initial excision. Vulvar leiomyomas are rare and may be misdiagnosed if the clinician is not aware. Even rarer still is combined vulvar and oesophageal leiomyomas, which may represent a specific syndrome. Treatments for isolated or syndromal vulvar leiomyoma are the same and should generally involve a marginal excision. Regular follow-up is warranted as late recurrence may occur.

Vulvar leiomyoma in association with gastrointestinal leiomyoma

Vulvar leiomyoma in association with gastrointestinal leiomyoma

Laparoscopic management of a pelvic retroperitoneal leiomyoma—case report

Leiomyomas are benign tumors frequently found in the fourth and fifth decades of life. Although the uterus is the most common site of origin of leiomyomas, they can develop at any site where there is smooth muscle cell. Extrauterine leiomyomas are not common and usually their diagnostic are more challenging. In this paper, we report one case of pelvic retroperitoneal leiomyoma associated to vulvar/perineal leiomyomas. A 47-year-old female patient presented with a 6-month history of deep dyspareunia, abdominal pain, dysuria, and pain during defecation. She had a previous history of two open myomectomies, a supracervical hysterectomy associated to the exeresis of a vulvar leiomyoma, and a left salpingo-oophorectomy. On vaginal examination, there was a tender and firm mass at the vaginal vault and along the posterior vaginal wall. There was another tumor at the left vulvar/perineal region measuring around 6 cm. Magnetic resonance imaging demonstrated the presence of a mass at the Douglas pouch measuring 14 × 10 × 10 cm suggestive of uterine leiomyomatosis. She underwent a successful laparoscopic resection of the pelvic tumor with an operative time of 210 min. The vulvar/perineal lesions were resected by vaginal approach. She presented an uneventful postoperative course and was discharged home 3 days after surgery. Histopathology confirmed the diagnosis of leiomyomas. Laparoscopic approach for pelvic retroperitoneal leiomyoma is feasible. It is important to keep in mind the possibility of this entity as a differential diagnosis of retroperitoneal masses in women.

A clonal translocation (7;8)(p13;q11.2) in a leiomyoma of the vulva

We present the first case of a vulvar leiomyoma studied by cytogenetics. The tumor formed a 3.0-cm periurethral nodule in a middle-aged woman and was positive for the muscle markers desmin and caldesmon, and for estrogen and progesterone receptors. Its karyotype was 46,XX,t(7;8)(p13;q11.2). This translocation has not been described in previously reported leiomyomas, regardless of their site of origin. The transcription factor PLAG1 gene at 8q12 was not altered by the translocation.

Ultrasound and MR Imaging Findings of Vulvar Leiomyoma: Case Report

Leiomyomas are common benign neoplasms that can occur at any anatomical site containing smooth muscle, though most originate in the female genital tract. Leiomyomas of the vulva or perineum are, however, very rare. We report the ultrasonographic (US) and MR imaging findings of a vulvar leiomyoma, and briefly review the literature.

SUPERFICIAL LEIOMYOMAS

The clinicopathologic findings of 34 cases of cutaneous and subcutaneous leiomyomas were described. These were composed of 12 cases of piloleiomyoma and 22 of genital leiomyoma (scrotum, nipple and areola, vulva, and perianal region). Thirteen of 22 genital leiomyomas occurred in the vulva. Four cases of leiomyoma of pilar arrector origin had multiple lesions. The tumor occurred predominantly in adult females with an approximate sex ratio of 1: 3 (8 males and 26 females). The patients with such leiomyomas ranged in age from 26 to 77 with an average of 46.8 years. The histologic feature in each case was essentially the same, and composed of interlacing bundles of smooth muscle cells, although vulvar leiomyomas frequently showed varying degrees of hyalinization and were composed of more slender tumor cells. All 12 cases submitted for immunohistochemistry showed a strongly positive staining both for actin and for desmin. In our view, cutaneous and subcutaneous leiomyomas, excluding angioleiomyomas, are undoubtedly rare in occurrence.