This paper aims at giving a contribution to the topic concerning the preservation of valuable adobe buildings, by setting a methodology for assessing their seismic vulnerability at the urban scale by means of analytical and numerical models, accounting for both their in-plane and out-of-plane behaviors. To this purpose, the valuable historical center of Cusco (Peru) is considered as representative case study. The city center of Cusco is an extraordinary example of colonial architecture that preserves essential aspects of its origins, it being representative of a large plethora of historical centers in South America and the Caribbean, where most of the residential buildings are made of adobe masonry.First, archetypes, representative of the whole historical center, are identified in order to get a manageable stock of buildings for which the analyses can be addressed to. The structural capacity of each archetype is then given in terms of capacity curves for both out-of-plane and in-plane mechanisms. Subsequently, these curves are compared with the likely seismic demands to assess the probability of attaining pre-established damage states for different seismic intensities. The obtained probabilities are collected into Damage Probability Matrices (DPMs) and, finally, cumulated to plot the fitting fragility curves.