Abstract A growing literature at the intersection of international relations, public policy, and comparative politics has explored the role that International Governmental Organizations (IGOs) play in influencing domestic policymaking. This literature is grounded in a commonly shared theoretical expectation that policymakers will perceive IGOs as neutral and technocratic purveyors of expert information. Based on this expectation, scholars have assumed that policymakers are likely to employ recommendations from IGOs when making decisions. In this research note, we examine this assumption through an analysis of original survey data on U.S. mayors’ responses to COVID-19-related guidance from the World Health Organization (WHO). In contrast to dominant theoretical expectations, we find that mayoral likelihood of considering WHO recommendations in policymaking and of trusting WHO-provided information was largely a function of ideology, an effect that remains after incorporating the interactive effect of Trump vote share.