Abstract Skillful prediction of the Southern Hemisphere (SH) eddy-driven jet is crucial for representation of mid-to-high-latitude SH climate variability. In the austral spring-to-summer months, the jet and the stratospheric polar vortex variabilities are strongly coupled. Since the vortex is more predictable and influenced by long-lead drivers 1 month or more ahead, the stratosphere is considered a promising pathway for improving forecasts in the region on subseasonal to seasonal (S2S) time scales. However, a quantification of this predictability has been lacking, as most modeling studies address only one of the several interacting drivers at a time, while statistical analyses quantify association but not skill. This methodological gap is addressed through a knowledge-driven probabilistic causal network approach, quantified with seasonal ensemble hindcast data. The approach enables to quantify the jet’s long-range predictability arising from known late-winter drivers, namely, El Niño–Southern Oscillation (ENSO), Indian Ocean dipole (IOD), upward wave activity flux, and polar night jet oscillation, mediated by the vortex variability in spring. Network-based predictions confirm the vortex as determinant for skillful jet predictions, both for the jet’s poleward shift in late spring and its equatorward shift in early summer. ENSO, IOD, late-winter wave activity flux, and polar night jet oscillation only provide moderate prediction skill to the vortex. This points to early spring submonthly variability as important for determining the vortex state leading up to its breakdown, creating a predictability bottleneck for the jet. The method developed here offers a new avenue to quantify the predictability provided by multiple, interacting drivers on S2S time scales. Significance Statement Predictions of the Southern Hemisphere midlatitude jet stream are crucial for skillful forecasts of the austral mid-to-high latitudes. Several oceanic and atmospheric phenomena could, if better represented in models, improve spring-to-summer jet predictions on subseasonal to seasonal time scales. However, the combined potential skill arising from the inclusion of such phenomena has not been quantified. This study does so by using a probabilistic causal network model, representing the connections between those drivers and the jet with conditional probabilities, trained on large sets of model data. The stratospheric polar vortex is confirmed as crucial predictor of jet variability but is itself hard to predict a month in advance due to submonthly variability, creating a predictability bottleneck for the jet.