A high-speed miniature pump design is put forth for utilization in the aerospace sector, where the pump’s reliability holds critical importance under microgravity operational conditions. This study focuses on a dynamic bearing-equipped miniature centrifugal pump, chosen for its suitability in investigating radial forces. The prototype of the miniature pump is manufactured and tested by experiments at the rotational speed of 10,000r/min. A good agreement is observed between the numerical predictions and the experimental results. The radial force acting on different blade part has been analyzed for several flow rate conditions using the steady state CFD calculation. It has been found that the radial force exerted on the blade trailing edge exit is the main cause of the total radial force for the impeller. Moreover, using the unsteady CFD simulation, the evolution process of the radial force changing for both the direction and the magnitude with respect to the annular position due to the shaft rotation is discussed in details. The pressure pulsation is also monitored in impeller and volute casing. The results show that the amplitude of the unsteady radial force has a strong relationship with the time it takes for the blade trailing edge exit passing the volute tongue region, while the direction of the radial force hardly changes. The findings of this study contribute to facilitating the broader implementation of the high-speed miniature pump across diverse sectors of society.