Use Of Volume Research Articles

RIFM fragrance ingredient safety assessment, cis-3-hexenyl tiglate, CAS Registry Number 67883-79-8

The existing information supports the use of this material as described in this safety assessment. cis-3-Hexenyl tiglate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analogs 2-methyl-trans-2-butenoic acid (CAS # 80-59-1) and cis-3-hexenol (CAS # 928-96-1) show that cis-3-hexenyl tiglate is not expected to be genotoxic. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the Threshold for Toxicological Concern (TTC) for a Cramer Class I material; exposure to cis-3-hexenyl tiglate is below the TTC (0.03 mg/kg/day, 0.03 mg/kg/day and 1.4 mg/day, respectively). Data from analog 2-hexenoic acid, 2-methyl-, methyl ester, (2E)- (CAS # 16493-96-2) provided cis-3-hexenyl tiglate a No Expected Sensitization Induction Level (NESIL) of 1100 μg/cm2 for the skin sensitization endpoint. The phototoxicity/photoallergenicity endpoints were evaluated based on ultraviolet/visible (UV/Vis) spectra; cis-3-hexenyl tiglate is not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated; cis-3-hexenyl tiglate was found not to be Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1.

ДОСЛІДЖЕННЯ СОЦІАЛЬНО-ЕКОНОМІЧНИХ ПЕРЕДУМОВ РОЗВИТКУ ДОНЕЦЬКОЇ ТА ЛУГАНСЬКОЇ ОБЛАСТЕЙ З УРАХУВАННЯМ ДІЯЛЬНОСТІ МАЛОГО БІЗНЕСУ

The study of socio-economic dimensions of the preconditions for the development of Donetsk and Luhansk regions allowed to distinguish between positive and negative directions of development. Thus, the positive prerequisites for the development of regions include: agricultural lands of Donetsk and Luhansk regions are characterized by high natural fertility; the mineral resource base of the regions is one of the most developed in terms of types and volumes of use of mineral resources in Ukraine, among which almost 50 % contains fuel and energy raw materials; an important place in the economy of Donetsk and Luhansk regions is occupied by industry; retail trade turnover of Donetsk and Luhansk regions from 2018-2020 begins to recover. It should also be noted that the Donetsk region is active in foreign economic activity, which has a significant impact on the development of the region, and the balance of foreign trade balance of the Donetsk region in 2014-2020 is positive. The positive trend of Luhansk region is that it has a significant share of small and medium business in the volume of sold products (goods, services). Negative prerequisites for the development of Donetsk and Luhansk regions are: the presence of armed conflict in the regions; loss of a significant part of industrial potential and reduction of indicators of socio-economic development of Donetsk and Luhansk regions; in 2020 lockdown and business interruptions due to the COVID-19 pandemic; there are logistical problems in the transportation of goods; in 2020, the level of exports is declining, most industrial enterprises engaged in foreign economic activity have significantly reduced production for export; destruction of key transport and logistics links, complication of railway logistics, closure of airspace, as a result of increased load on roads from heavy, large, freight transport, in the Donetsk region there is a destruction of road surface. Also, the negative trends of Donetsk region include the lowest share of small and medium business in the volume of sold products (goods, services). The positive preconditions for the development of Donetsk and Luhansk oblasts need support in the direction of strengthening these tendencies. Negative preconditions for the development of oblasts require significant changes and financial investments for radical changes in the direction of improving the situation. Thus, the intensification of small business in the Donetsk region and support for the further development of small business in the Luhansk region is a prerequisite for economic growth in these areas in the future.

Utilization trends of Proton Pump Inhibitors in South Korea: Analysis using 2016-2020 Healthcare Bigdata Hub by Health Insurance Review and Assessment Service

Proton Pump Inhibitors (PPIs) are drugs that inhibit gastric acid secretion and are widely used globally. With the aging population and the rising prevalence of gastrointestinal diseases in Korea, the number of patients using PPIs is increasing. Therefore, we investigated the current state of PPI utilization at the national level using the nationwide database, Healthcare Bigdata Hub compiled by the Health Insurance Review and Assessment Service (HIRA). We extracted the statistics from 2016 to 2020 and re-organized them into monthly utilization by treatments. The cost and volume of use by region, provider type, and diagnostic code were extracted for five PPIs: pantoprazole, rabeprazole, omeprazole, esomeprazole, and lansoprazole. The volume of use was converted into Defined Daily Dose (DDD), which is the standardized unit of utilization. Esomeprazole and rabeprazole were the most commonly used PPIs, and esomeprazole has shown a sharp increase recently. The crude utilization of each region was the highest in Seoul, but that in Daegu and Jeonbuk was the highest after adjusting for the population size. The utilization of PPIs has increased in all diagnostic codes, and Gastroesophageal Reflux Disease (GERD) accounts for the highest proportion. Despite emerging concerns on the adverse outcomes of long-term PPI utilization, their consumption has increased in recent years. These results on the variations by region and trends by diagnostic code thus address a good basis for future research and policies regarding PPIs.

RIFM fragrance ingredient safety assessment, 4,8-decadienal, (4Z,8Z)-, CAS Registry Number 1958027-35-4

Summary: The existing information supports the use of this material as described in this safety assessment.4,8-Decadienal, (4Z,8Z)- was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analogs 4,7-decadienal (CAS # 934534-30-2) and nona-2-trans-6-cis-dienal (CAS # 557-48-2) show that 4,8-decadienal, (4Z,8Z)- is not expected to be genotoxic. Data on analog 10-undecenal (CAS # 112-45-8) provide a calculated Margin of Exposure (MOE) > 100 for the repeated dose toxicity and fertility endpoints and a No Expected Sensitization Induction Level (NESIL) of 1700 μg/cm2 for the skin sensitization endpoint. The developmental toxicity and local respiratory toxicity endpoints were evaluated using the Threshold of Toxicological Concern (TTC) for Cramer Class I materials; exposure is below the TTC (0.03 mg/kg/day and 1.4 mg/day, respectively). The phototoxicity/photoallergenicity endpoints were evaluated based on ultraviolet/visible (UV/Vis) spectra; 4,8-decadienal, (4Z,8Z)- is not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated; 4,8-decadienal, (4Z,8Z)- was found not to be Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards. Its risk quotients, based on its current volume of use in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1.

RIFM fragrance ingredient safety assessment, dihydrocarvyl acetate, CAS Registry Number 20777-49-5

The existing information supports the use of this material as described in this safety assessment. Dihydrocarvyl acetate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analogs dihydrocarveol (isomer unspecified) (CAS # 619-01-2) and acetic acid (CAS # 64-19-7) show that dihydrocarvyl acetate is not expected to be genotoxic. Data on read-across analogs isopulegol (CAS # 89-79-2) and acetic acid (CAS # 64-19-7 provide a calculated MOE >100 for the repeated dose toxicity endpoint. The reproductive and local respiratory toxicity endpoints were evaluated using the TTC for a Cramer Class I material, and the exposure to dihydrocarvyl acetate is below the TTC (0.03 mg/kg/day and 1.4 mg/day, respectively). Data from read-across analog 4-methyl-8-methylenetricyclo [3.3.1.(3,7)]decan-2-yl acetate (CAS # 122,760-85-4) provided dihydrocarvyl acetate a NESIL of 2500 μg/cm2 for the skin sensitization endpoint. The phototoxicity/photoallergenicity endpoints were evaluated based on UV/Vis spectra; dihydrocarvyl acetate is not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated; dihydrocarvyl acetate was found not to be PBT as per the IFRA Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., PEC/PNEC), are <1.

Supplemental Material for The role of depression in the discrepancy between estimated and actual smartphone use: A cubic response surface analysis.

The association between depression and digital media use (DMU) has received substantial research and popular attention in recent years. While meta-analytic evidence indicates that there is a small, positive relationship between DMU and depression, almost all studies rely on self-report measures of DMU. Evidence suggests these measures are poor reflections of usage measures derived from digital trace data. Additionally, a recent study showed that the error in self-reported DMU is likely biased systematically by factors that are fundamental to the effect being investigated: respondents’ volume of use and level of depression. The present study harnesses cubic response surface analysis—a novel analytical approach in this domain—to advance our understanding of how inaccuracies in self-report measures of DMU can be explained by respondent attributes, in this case their level of depression and actual iPhone usage. A sample of 325 iPhone users provided estimates of their total iPhone use over the past week, their actual iPhone use as recorded by the Apple Screen Time application, and a measure of their depression. The results of the analysis indicate that depression is (a) more strongly associated with estimated than device-logged DMU; (b) more associated with overestimating than underestimating of DMU; and (c) more associated with inaccuracy at lower versus higher levels of DMU. The findings raise important questions concerning the validity of conclusions in this area and provide insight into the structure of measurement error in self-report estimates of DMU.

The role of depression in the discrepancy between estimated and actual smartphone use: A cubic response surface analysis.

The association between depression and digital media use (DMU) has received substantial research and popular attention in recent years. While meta-analytic evidence indicates that there is a small, positive relationship between DMU and depression, almost all studies rely on self-report measures of DMU. Evidence suggests these measures are poor reflections of usage measures derived from digital trace data. Additionally, a recent study showed that the error in self-reported DMU is likely biased systematically by factors that are fundamental to the effect being investigated: respondents’ volume of use and level of depression. The present study harnesses cubic response surface analysis—a novel analytical approach in this domain—to advance our understanding of how inaccuracies in self-report measures of DMU can be explained by respondent attributes, in this case their level of depression and actual iPhone usage. A sample of 325 iPhone users provided estimates of their total iPhone use over the past week, their actual iPhone use as recorded by the Apple Screen Time application, and a measure of their depression. The results of the analysis indicate that depression is (a) more strongly associated with estimated than device-logged DMU; (b) more associated with overestimating than underestimating of DMU; and (c) more associated with inaccuracy at lower versus higher levels of DMU. The findings raise important questions concerning the validity of conclusions in this area and provide insight into the structure of measurement error in self-report estimates of DMU.

The use of waste from the production of gravel as fertilizer for cultivation of technical energy crops

The object of research is the process of management and treatment of crushed stone production waste. Modern approaches to the disposal of crushed stone production waste are analyzed. It is revealed that crushed stone production wastes are mainly used in the construction industry, and their volumes of use are insufficient to neutralize the impact of dumps on the environment. The chemical composition of crushed stone production wastes was analyzed and an experiment was carried out to determine the possibility of their use as fertilizers for the cultivation of industrial energy crops. For the experiment, an energy crop was chosen – sorghum. Sorghum seeds were placed in two types of soil: regular peat substrate and peat substrate with the addition of rock in a ratio of 60:40. Waste from crushed stone production – rock, which includes: quartzite – 90–98 %, pyrophyllite – 1–9 %, ore mineral – 0.3–1 %. The results of the experiment showed an increase in the biomass of sorghum grown on a peat substrate with the addition of rock, 1.5 times, compared with that grown on a conventional peat substrate. Accordingly, the energy yield of sorghum per hectare of field will also grow by 50 %. In addition to increasing the biomass of sorghum, as a result of the experiment, an increase in the number of secondary and tertiary roots was found when it was grown on a peat substrate with the addition of rock. A more developed root system allows the plant to receive more moisture and nutrients, thereby increasing its endurance and drought resistance. The results obtained can be explained by the positive effect of silica, of which more than 90 % of the rock is composed, on the growth and development of plants. It is proposed to increase the level of environmental safety of mining regions through the use of crushed stone waste as fertilizers for industrial energy crops and the transition to alternative energy sources, in particular biofuels made on the basis of these crops.

RIFM fragrance ingredient safety assessment, 1-heptanethiol, CAS Registry Number 1639-09-4

1-Heptanethiol was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog 1-octanethiol (CAS # 111-88-6) show that 1-heptanethiol is not expected to be genotoxic and provide a calculated MOE >100 for the reproductive toxicity endpoint. Data on read-across analog dodecanethiol (CAS # 112-55-0) provide a calculated MOE >100 for the repeated dose toxicity endpoint. Data show that there are no safety concerns for 1-heptanethiol for skin sensitization under the current declared levels of use. The phototoxicity/photoallergenicity endpoints were evaluated based on UV/Vis spectra for read-across analog methyl mercaptan (CAS # 74-93-1); 1-heptanethiol is not expected to be phototoxic/photoallergenic. The local respiratory toxicity endpoint was evaluated using the TTC for a Cramer Class I material; exposure is below the TTC (1.4 mg/day). The environmental endpoints were evaluated; 1-heptanethiol was found not to be PBT as per the IFRA Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., PEC/PNEC), are <1.

Change in Psychoactive Substance Consumption in Relation to Psychological Distress During the COVID-19 Pandemic in Uruguay.

ObjectivesThis study aimed to analyse how the health crisis associated with the COVID-19 pandemic affected psychoactive substance consumption in Uruguay.MethodsAn online survey was answered by 1,916 Uruguayan citizens between March and April 2020 regarding psychoactive substance use before and after the instauration of a recommended quarantine, increases in frequency and volume of use (during the quarantine) of the psychoactive substance they reported as having consumed the most in the year prior to the quarantine and psychological distress experienced during the last month.ResultsThe main substances consumed during the quarantine were alcohol, tobacco, marijuana and psychopharmaceuticals. Approximately 28% of respondents increased the volume (and 17.7%, the frequency) of use of the substance they had consumed the most the year before the instauration of the quarantine. Moreover, 5.7% initiated the consumption of a new psychoactive substance during the quarantine, mostly marijuana and psychopharmaceuticals. Psychological distress was significantly higher among women, participants under 30 and among those that increased the volume of their most or second preferred psychoactive substance. The group reporting an increase in the volume of use exhibited greater psychological distress.ConclusionThese results indicate an association between the instauration of the recommended quarantine in Uruguay and greater psychoactive substance use during the period as well as an association between increased psychoactive substance use during this period and levels of psychological stress. These results are relevant in terms of public health and policies.

Mechanical mapping of bioprinted hydrogel models by brillouin microscopy

Three-dimensional (3D) bioprinting has revolutionised the field of biofabrication by delivering precise, cost-effective and a relatively simple way of engineering in vitro living systems in high volume for use in tissue regeneration, biological modelling, drug testing and cell-based diagnostics. The complexity of modern bioprinted systems requires quality control assessment to ensure the resulting product meets the desired criteria of structural design, micromechanical performance and long-term durability. Brillouin microscopy could be an excellent solution for micromechanical assessment of the bioprinted models during or post-fabrication since this technology is non-destructive, label-free and is capable of microscale 3D imaging. In this work, we demonstrate the application of Brillouin microscopy to 3D imaging of hydrogel microstructures created through drop-on-demand bioprinting. In addition, we show that this technology can resolve variations between mechanical properties of the gels with slightly different polymer fractions. This work confirms that Brillouin microscopy can be seen as a characterisation technology complementary to bioprinting, and in the future can be combined within the printer design to achieve simultaneous real-time fabrication and micromechanical characterisation of in vitro biological systems.

RIFM fragrance ingredient safety assessment, 6-nonenenitrile, (Z)- (9CI), CAS Registry Number 80639-54-9

The existing information supports the use of this material as described in this safety assessment. 6-Nonenenitrile, (Z)- (9CI) was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog 3-(cis-3-hexenyloxy)propanenitrile (CAS # 142653-61-0) show that 6-nonenenitrile, (Z)- (9CI) is not expected to be genotoxic. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class III material, and the exposure to 6-nonenenitrile, (Z)- (9CI) is below the TTC (0.0015 mg/kg/day, 0.0015 mg/kg/day, and 0.47 mg/day, respectively). Data from read-across analog 3-(cis-3-hexenyloxy)propanenitrile (CAS # 142653-61-0) show that there are no safety concerns for 6-nonenenitrile, (Z)- (9CI) for skin sensitization under the current declared levels of use. The phototoxicity/photoallergenicity endpoints were evaluated based on ultraviolet (UV) spectra; 6-nonenenitrile, (Z)- (9CI) is not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated; 6-nonenenitrile, (Z)- (9CI) was found not to be Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1.

RIFM fragrance ingredient safety assessment, hexadeca-1,5-lactone, CAS Registry Number 7370-44-7

The existing information supports the use of this material as described in this safety assessment.Hexadeca-1,5-lactone was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from the target material and read-across analog hydroxynonanoic acid, δ-lactone (CAS # 3301-94-8) show that hexadeca-1,5-lactone is not expected to be genotoxic. Data from analog δ-decalactone (CAS # 705-86-2) provide a calculated Margin of Exposure (MOE) > 100 for the repeated dose and reproductive toxicity endpoints. Data from analog δ-octalactone (CAS # 698-76-0) show that there are no safety concerns for skin sensitization under the current declared levels of use. The phototoxicity/photoallergenicity endpoints were evaluated based on ultraviolet (UV) spectra; hexadeca-1,5-lactone is not expected to be phototoxic/photoallergenic. The local respiratory toxicity endpoint was evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class I material; exposure is below the TTC (1.4 mg/day). For the hazard assessment based on the screening data, hexadeca-1,5-lactone is not Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards. Hexadeca-1,5-lactone could not be risk screened as there were no reported volumes of use for either North America or Europe in the 2015 IFRA Survey.

RIFM fragrance ingredient safety assessment, butyl lactate, CAS registry number 138-22-7

The existing information supports the use of this material as described in this safety assessment.Butyl lactate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog ethyl (L)-lactate (CAS # 687-47-8) show that butyl lactate is not expected to be genotoxic. Data on read-across materials butyl alcohol (CAS # 71-36-3) and lactic acid (CAS # 50-21-5) provide a calculated margin of exposure (MOE) > 100 for the repeated dose and reproductive toxicity endpoints. The skin sensitization endpoint was completed using the dermal sensitization threshold (DST) for non-reactive materials (900 μg/cm2); exposure is below the DST. The phototoxicity/photoallergenicity endpoints were evaluated based on ultraviolet (UV) spectra; butyl lactate is not expected to be phototoxic/photoallergenic. Data on butyl lactate provide a calculated MOE >100 for the local respiratory endpoint. The environmental endpoints were evaluated; butyl lactate was found not to be Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1.

RIFM fragrance ingredient safety assessment, ethyl 2-methyl-4-pentenoate, CAS Registry Number 53399-81-8

The existing information supports the use of this material as described in this safety assessment.Ethyl 2-methyl-4-pentenoate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog methyl undec-10-enoate (CAS # 111-81-9) show that ethyl 2-methyl-4-pentenoate is not expected to be genotoxic. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the threshold of toxicological concern (TTC) for a Cramer Class I material, and the exposure to ethyl 2-methyl-4-pentenoate is below the TTC (0.03 mg/kg/day, 0.03 mg/kg/day, and 1.4 mg/day, respectively). The skin sensitization endpoint was completed using the Dermal Sensitization Threshold (DST) for non-reactive materials (900 μg/cm2); exposure is below the DST. The phototoxicity/photoallergenicity endpoints were evaluated based on ultraviolet/visible (UV/Vis) spectra; ethyl 2-methyl-4-pentenoate is not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated; ethyl 2-methyl-4-pentenoate was found not to be Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1.

RIFM fragrance ingredient safety assessment, 5- and 6-decenoic acid, CAS Registry Number 72881-27-7

Summary: The existing information supports the use of this material as described in this safety assessment.5- and 6-Decenoic acid was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog oleic acid (CAS # 112-80-1) show that 5- and 6-decenoic acid is not expected to be genotoxic. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the threshold of toxicological concern (TTC) for a Cramer Class I material, and the exposure to 5- and 6-decenoic acid is below the TTC (0.03 mg/kg/day, 0.03 mg/kg/day, and 1.4 mg/day, respectively). The skin sensitization endpoint was completed using the dermal sensitization threshold (DST) for non-reactive materials (900 μg/cm2); exposure is below the DST. The phototoxicity/photoallergenicity endpoints were evaluated based on ultraviolet/visible (UV/Vis) spectra; 5- and 6-decenoic acid is not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated; 5- and 6-decenoic acid was found not to be persistent, bioaccumulative, and toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1.

О вовлечении отвалов горной массы в хозяйственный оборот и месте в этом процессе буровзрывных работ

On the territory of the Russian Federation, exactly as in the rest of the world, huge amounts of mining waste have been accumulated. Most of them in open-pit mining are dumps of rock mass that occupy huge territories and have a significant negative impact on the earth's ecology. Most of the dumps are non-toxic and can be used for economic purposes where sand and stone are needed-in construction. However, the volumes are too large and only a small part can be used for the production of building materials. Another thing is if you need a large amount of rock for the construction of a long roadbed. There are other requirements for raw materials and the possibility of releasing large areas occupied by dumps. This direction has significant potential, because on the one hand, cheap construction raw materials, and on the other – a reduction in fees for the use of land (especially relevant for large mining and processing plants). The development of dumps as man-made deposits has its own risks and associated problems. However, it leads to the development of new technological solutions, which in turn opens up certain prospects for subsoil users. Currently, this direction is in its infancy, but the scale of the problem of storing dumps is already obvious. Therefore, despite the doubts, recycling of dumps is inevitable. It is also clear that this processing should be in huge volumes. And such volumes of use in the Russian Federation can only be achieved when building roads.

Evaluation of the reproductive ability of crossbred sows obtained from different breeding boars

In order to improve the livestock industry, and push up it to the world level making full use of the biological features of animals it is necessary to radically improve the system of breeding work with the species selection and the best combinations to obtain the fattening of young animals, in the implementation of this task special emphasis on the pig as the most precocious and technologically advanced livestock industry. The advantage of pork production is evidenced by the economic assessment of meat production of diff erent types of animals according to the level of individual costs for the nutrients of the product. It is no coincidence that the growth rate of pork production in the world in recent years exceeds the growth rate of beef and poultry. The purpose of the work was to assess the reproductive traits of crossbred sows obtained from various dreeding boars of Landrace breed (1st paternal breed) and mated with breeding boar of Duroc breed (2nd paternal breed) during three-breed industrial crossbreeding. The research has been carried out on the basis of LLC “Agrofi rma Ariant” in the Chelyabinsk region. It has been found that among the analyzed crossbreds the highest reproductive abilities were distinguished by sows obtained from the breeding boar No. 62143 their prolifi cacy was 13,5 heads live piglets, and the live weight of 1 piglet at birth was 1448,07 g, which exceeded the indicators of sows daughters of breeding boar No. 620001 by 1,4 piglets, and 17,9 g, respectively. Approximately the same number of female pigs has been obtained in both study groups. The number of young boars from sows of breeding boar No. 62143 was by 1,3 head more. Thus, in order to increase the profi tability of pork production in LLC “Agrofi rma Ariant” it is necessary to increase the volume of use of sperm of breeding boar No. 62143 of Landrace breed

Improve the Consumption of Cement and Sand in Massive Concrete

The massive concretemixing plan is very important due to its large volume of use in concrete dams.Productivity can be increased in dam manufacturing industry by adopting asuitable method for mixing mass concrete that can meet design, executive andeconomic needs. Because of intensification rate construction of dams newperiods and high cost of implementing such projects any step that reduces theircost of construction can lead to better use of national capital and rapidreturn on capital. One of the points that canbe made to reduce costs is the concrete mixing plan in all of these projectsespecially concrete dams due to high amount of concrete used. Considering thatthe required resistance in the body of concrete dam is not very high so theamount of using water in the massive concrete should be such that it ispossible to install the concrete with machines. Description overall boundaryheat in condensed concrete to avoid fracture and sturdiness issues. Protectionconcrete heat inside restrictions is a problematic issue.

Use of Databases and eBooks in International Schools in Hong Kong

This usage of online databases and eBooks in three international secondary schools in Hong Kong is investigated from the student perspective. Major issues relating to e-Resources surfaced include: student preferences for eResources, WWW or print materials; volume of use, and reasons for use; students’ perceived retrieval ability; and ease of use of e-Resources. The implications of library policies and information literacy training are explored. The results raise issues that can assist school librarians to make informed decisions about e-Resource acquisitions and related library activities, such as the need for user education and promotion of e-Resources.