Volume Scans Research Articles

A Corrugated Edged Tapered Slot Antenna with Low Cross-Polarization and Moderate Gain for Phased Array Systems

ABSTRACT This paper presents a miniaturized Vivaldi antenna with a scan volume of ± 30° designed for the 6–18 GHz tactical operational band, commonly employed in phased array systems and modern surveillance applications. The proposed antenna offers enhanced radiation characteristics, low cross polarization, broad beam width, and moderate gain. The design presented in this paper follows a step-by-step approach to achieve enhanced performance in terms of multi-octave bandwidth and compact size. Initially, a traditional Vivaldi antenna was designed and examined, with a modified feed structure. Subsequently, corrugated edges were inserted into the antenna, increasing its electrical length and resulting in good impedance matching, especially in the 6–10 GHz frequency band. A prototype model is fabricated and tested to validate its performance against the simulation results. The measured results demonstrate that the return loss (S11) remains below −10 dB across the operating frequency range, achieving a 50% bandwidth, with a gain of 3–7 dB, and improved co-cross polarization of −23 dB at 6 GHz and −26 dB at 18 GHz.

Prediction of presence and severity of metabolic syndrome using regional body volumes measured by a multisensor white-light 3D scanner and validation using a mobile technology

Abstract Aims To test whether an index based on the combination of demographics and body volumes obtained with a multisensor 3D body volume (3D-BV) scanner and biplane imaging using a mobile application (myBVI®) will reliably predict the severity and presence of metabolic syndrome (MS). Methods and results We enrolled 1280 consecutive subjects who completed study protocol measurements, including 3D-BV and myBVI®. Body volumes and demographics were screened using the least absolute shrinkage and selection operator to select features associated with an MS severity score and prevalence. We randomly selected 80% of the subjects to train the models, and performance was assessed in 20% of the remaining observations and externally validated on 133 volunteers who prospectively underwent myBVI® measurements. The mean ± SD age was 43.7 ± 12.2 years, 63.7% were women, body mass index (BMI) was 28.2 ± 6.2 kg/m2, and 30.2% had MS and an MS severity z-score of −0.2 ± 0.9. Features β coefficients equal to zero were removed from the model, and 14 were included in the final model and used to calculate the body volume index (BVI), demonstrating an area under the receiving operating curve (AUC) of 0.83 in the validation set. The myBVI® cohort had a mean age of 33 ± 10.3 years, 61% of whom were women, 10.5% MS, an average MS severity z-score of −0.8, and an AUC of 0.88. Conclusion The described BVI model was associated with an increased severity and prevalence of MS compared with BMI and waist-to-hip ratio. Validation of the BVI had excellent performance when using myBVI®. This model could serve as a powerful screening tool for identifying MS.

Reproducibility of a single-volume dynamic CT myocardial blood flow measurement technique: validation in a swine model

BackgroundWe prospectively assessed the reproducibility of a novel low-dose single-volume dynamic computed tomography (CT) myocardial blood flow measurement technique.MethodsThirty-four pairs of measurements were made under rest and stress conditions in 13 swine (54.3 ± 12.3 kg). One or two acquisition pairs were acquired in each animal with a 10-min delay between each pair. Contrast (370 mgI/mL; 0.5 mL/kg) and a diluted contrast/saline chaser (0.5 mL/kg; 30:70 contrast/saline) were injected peripherally at 5 mL/s, followed by bolus tracking and acquisition of a single volume scan (100 kVp; 200 mA) with a 320-slice CT scanner. Bolus tracking and single volume scan data were used to derive perfusion in mL/min/g using a first-pass analysis model; the coronary perfusion territories of the left anterior descending (LAD), left circumflex (LCx), and right coronary artery (RCA) were automatically assigned using a previously validated minimum-cost path technique. The reproducibility of CT myocardial perfusion measurement within the LAD, LCx, RCA, and the whole myocardium was assessed via regression analysis. The average CT dose index (CTDI) of perfusion measurement was recorded.ResultsThe repeated first (Pmyo1) and second (Pmyo2) single-volume CT perfusion measurements were related by Pmyo2 = 1.01Pmyo1 − 0.03(ρ = 0.96; RMSE = 0.08 mL/min/g; RMSE = 0.07 mL/min/g) for the whole myocardium, and by Preg2 = 0.86Preg1 + 0.13(ρ = 0.87; RMSE = 0.31 mL/min/g; RMSE = 0.29 mL/min/g) for the LAD, LCx, and RCA perfusion territories. The average CTDI of the single-volume CT perfusion measurement was 10.5 mGy.ConclusionThe single-volume CT blood flow measurement technique provides reproducible low-dose myocardial perfusion measurement using only bolus tracking data and a single whole-heart volume scan.Relevance statementThe single-volume CT blood flow measurement technique is a noninvasive tool that reproducibly measures myocardial perfusion and provides coronary CT angiograms, allowing for simultaneous anatomic-physiologic assessment of myocardial ischemia.Key PointsA low-dose single-volume dynamic CT myocardial blood flow measurement technique is reproducible.Motion misregistration artifacts are eliminated using a single-volume CT perfusion technique.This technique enables combined anatomic-physiologic assessment of coronary artery disease.Graphical

Point-of-Care Ultrasound Track in an Academic Family Medicine Department.

Point-of-care ultrasound (POCUS) is increasingly being employed in family medicine. Residency tracks can be an effective way to increase mastery in a specific subdiscipline for interested residents, but no studies exist on the implementation of a POCUS track in family medicine. We address this gap in the literature by assessing POCUS use by POCUS track residents compared to non-POCUS track residents and faculty in an academic family medicine department. We performed a retrospective review of all POCUS scans completed in the first year after implementation of a family medicine residency POCUS track. Scans were analyzed by two reviewers. We compared scan volume and type between POCUS track residents, non-POCUS track residents, and faculty. A blinded quality analysis was performed on each group of scans. A total of 572 scans were completed on 536 patients over 1 year. POCUS track residents scanned significantly more than non-POCUS track residents (mean difference of 72.2, CI 59.1 to 85.4; P<.0001). The most common scan types across groups were musculoskeletal and soft tissue. POCUS track residents showed statistically improved scan quality in all scan types, while non-POCUS track residents showed statistical improvement only in soft tissue, shoulder, and abdominal aortic aneurysm scans. This is the first longitudinal study of a novel academic family medicine residency POCUS track. Participation in a POCUS track can increase the number, variety, and quality of scans performed. Our curriculum can be a model for family medicine residency programs that wish to provide robust POCUS training.

Optimal configurations of an electromagnetic tracking system for 3D ultrasound imaging of pediatric hips – A phantom study

Tracking the position and orientation of a two-dimensional (2D) ultrasound scanner to reconstruct a 3D volume is common, and its accuracy is important. In this study, a specific miniaturized electromagnetic (EM) tracking system was selected and integrated with a 2D ultrasound scanner, which was aimed to capture hip displacement in children with cerebral palsy. The objective of this study was to determine the optimum configuration, including the distance between the EM source and sensor, to provide maximum accuracy. The scanning volume was aimed to be 320 mm × 320 mm × 76 mm. The accuracy of the EM tracking was evaluated by comparing its tracking with those from a motion capture camera system. A static experiment showed that a warm-up time of 20 min was needed. The EM system provided the highest precision of 0.07 mm and 0.01° when the distance between the EM source and sensor was 0.65 m. Within the testing volume, the maximum position and rotational errors were 2.31 mm and 1.48°, respectively. The maximum error of measuring hip displacement on the 3D hip phantom study was 4 %. Based on the test results, the tested EM system was suitable for 3D ultrasound imaging of pediatric hips to assess hip displacement when optimal configuration was used.

An Automated Approach to Estimating Convective Boundary Layer Depth from Dual-Polarization WSR-88D Radar Observations

Abstract Convective boundary layer (CBL) depth can be estimated from dual-polarization WSR-88D radars using the product differential reflectivity ZDR because the CBL top is collocated with a local ZDR minimum produced by Bragg scatter at the interface of the CBL and the free troposphere. Quasi-vertical profiles (QVPs) of ZDR are produced for each radar volume scan and profiles from successive times are stitched together to form a time–height plot of ZDR from sunrise to sunset. QVPs of ZDR often show a low-ZDR channel that starts near the ground and rises during the morning and early afternoon, identifying the CBL top. Unfortunately, results show that this channel within the QVP can occasionally be misleading. This motivated creation of a new variable DVar, which combines ZDR with its azimuthal variance and is particularly helpful at identifying the CBL top during the morning hours. Two methods are developed to track the CBL top from QVPs of ZDR and DVar. Although each method has strengths and weaknesses, the best results are found when the two methods are combined using inverse variance weighting. The ability to detect CBL depth from routine WSR-88D radar scans rather than from rawinsondes or lidar instruments would vastly improve our understanding of CBL depth variations in the daytime by increasing the temporal and spatial frequencies of the observations. Significance Statement The daytime convective boundary layer (CBL) can increase in depth from a few hundred to a few thousand meters between sunrise and sunset and is strongly connected to temperature changes at Earth’s surface. Unfortunately, current observations of CBL depth primarily consist of measurements from twice daily rawinsonde launches at 97 locations across the United States. As a result, CBL depth observations lack fine spatial and temporal resolution and miss the daily cycle of CBL growth. This study seeks to fill the gaps in CBL depth observations by developing an automated method to estimate CBL depth from dual-polarization WSR-88D radar observations with a temporal resolution as fine as 5–10 min. These observations will greatly enhance our ability to observe and monitor CBL depth in real time.

Exploring single-mode VCSEL wavelength tuning for low-cost 3D optical coherence tomography and OCT angiography.

Low-cost optical coherence tomography has recently emerged as a growing field due to the increased need for general availability of OCT devices outside of the clinics. One of the main obstacles in creating low-cost SS-OCT systems is the price of the laser. In this work, we study the influence of different tuning parameters (e.g., frequency, duty cycle, modulation curve, temperature) on the resulting bandwidth of the previously proposed low-cost single-mode thermally-tunable vertical-cavity surface-emitting laser (VCSEL) source at 850 nm. With optimal parameters, the laser achieves a tuning bandwidth of 10.2 nm at a 50 kHz A-scan rate. In addition, we show the first 3D rendered volume scans of both anterior and posterior segment using a custom VCSEL-based low-cost OCT setup. With the help of deep-learning-based denoising, it was possible to critically reduce the noise in single scans. Moreover, by investigating the phase stability, it became apparent that phase stability between sweeps increases with rising modulation frequencies, making the auxiliary interferometer obsolete. Thus, the system's 50 kHz tuning regimen is also suitable for functional extensions such as OCT angiography.

Slotted meandered waveguide antenna for X-band radar applications

ABSTRACT This work presents a unique one-dimensional (1D) FSA powered by rectangular meander waveguide which finds usage in bird monitoring and detection in wind farms. Large scan volume, high frequency sensitivity, lower side lobe level and excellent directivity are few of the varied advantages of the suggested approach. The suggested travelling-wave FSA operates in the X-band uses a periodically loaded standard WR90 waveguide and is vertically polarised. The propagation properties and fundamental ideas of the meander-line unit are thoroughly studied for frequency-scanning based applications. The scanning performance over frequency range is enhanced by using the proposed meandering feeding mechanism. Dumbbell-shaped radiating slots are utilised in the waveguide. The beam width in the elevation plane is narrowed by embedding an E-plane horn antenna over it. Using CST microwave studio, the proposed FSA with 10 radiating elements is simulated in order to predict the scanning performance over the frequency range of 9.425 to 10.025 GHz. The results demonstrate a gain above 21 dBi and a high 55-degree scanning coverage performance. The lower SLL is observed around 13 dB. Aluminium is used in the fabrication of the suggested approach. When the FSA is evaluated after manufacture, measurements and simulations accord quite well.

RETINAL STRUCTURAL CHANGES AFTER CESSATION OF PENTOSAN POLYSULFATE SODIUM.

To quantify baseline and longitudinal structural changes post-cessation in patients with pentosan polysulfate sodium retinopathy. This is a retrospective cohort study. Retinal thickness and volume of choroidal and hyperreflective retinal pigment epithelium excrescences were manually segmented from optical coherence tomography volume scans. Baseline measurements were compared against age-matched control subjects. Longitudinal measurements were performed on patients with follow-up data. Twenty-four eyes of 13 patients were included. At baseline, the mean total retinal thickness was lower in the pentosan polysulfate sodium retinopathy cohort than in age- and sex-matched control subjects (269.1 µ m vs. 290.2 µ m, P = 0.006). The median (range) of follow-up was 18.6 (4.1-34.7) months, with the mean last follow-up of 35.2 months after cessation. During the follow-up period, the thickness of the retina decreased significantly by 11.3 µ m (CI: 16.8, 5.8) ( P < 0.001), with an annual mean decrease of 6.70 µ m. However, the mean hyperreflective retinal pigment epithelium excrescence volume did not change significantly ( P = 0.140) over the follow-up period. After pentosan polysulfate sodium discontinuation, although retinal pigment epithelium excrescence volume do not change significantly, there continues to be a progressive long-term thinning of the retina, which continues at a rate greater than that associated with normal aging. Consequently, long-term follow-up is suggested to monitor patients with pentosan polysulfate sodium retinopathy.

Estimating Effective Diameter and Scan Length of Abdomen and Pelvis for Radiation Dose Optimization in Computed Tomography Imaging Suitable for the Indian Population – A Preliminary Study

Abstract Background: Utilization of computed tomography (CT) has dramatically increased during the last decade with a concurrent increase in exposure to ionizing radiation. Even low levels of exposure have been linked to the development of cancer. Various dose reduction and optimization techniques have been attempted to minimize the risk. Dose optimization becomes crucial when scanning thin and small-built individuals, particularly children. Reference phantoms of European or North American descent are used to develop radiological protocols. CT dose index (CTDI) metrics like scan length, volume CTDI, and dose-length product help to measure the amount of radiation dose received by patients during CT scans. Methodolgy: We studied the anatomical dimensions of the CT abdomen and pelvis from the topographic and tomographic images using the standard bony landmarks in 340 children and 500 adults (F = 250, M = 250) and. Cross-sectional measurements and effective diameter were also used to generate CT phantom models. Results: Using measured variables, phantom models have been generated in different age groups in children and adults representative of the Indian population showing a significant increase in dimensions from pediatric to adult phantom. Dimensions vary from classic reference phantoms of European or North American descent. Conclusion: Diagnostic reference levels must be adjusted according to the age of the patient, size of organs, or surface area of examination as body proportions vary between age groups, sex, and race. Data from this study can be used to generate the age- and sex-specific preset protocols for dose optimization in the adult Indian and pediatric population to minimize exposure risk, particularly in young children.

Three-Dimensional Reconstruction of Subbasal Nerve Density in Eyes With Limbal Stem Cell Deficiency: A Pilot Study.

Corneal subbasal nerve parameters have been previously reported using 2-dimensional scans of in vivo laser scanning confocal microscopy (IVCM) in eyes with limbal stem cell deficiency (LSCD). This study aims to develop and validate a method to better quantify corneal subbasal nerve parameters and changes from reconstructed 3-dimensional (3D) images. IVCM volume scans from 73 eyes with various degrees of LSCD (mild/moderate/severe) confirmed by multimodal anterior segment imaging including IVCM and 20 control subjects were included. Using ImageJ, the scans were manually aligned and compiled to generate a 3D reconstruction. Using filament-tracing semiautomated software (Imaris), subbasal nerve density (SND), corneal nerve fiber length, long nerves (>200 μm), and branch points were quantified and correlated with other biomarkers of LSCD. 3D SND decreased in eyes with LSCD when compared with control subjects. The decrease was significant for moderate and severe LSCD ( P < 0.01). 3D SND was reduced by 3.7% in mild LSCD, 32.4% in moderate LSCD, and 96.5% in severe LSCD. The number of long nerves and points of branching correlated with the severity of LSCD ( P < 0.0001) and with declining SND (R 2 = 0.66 and 0.67, respectively). When compared with 2-dimensional scans, 3D reconstructions yielded significant increases of SND and branch points in all conditions except severe LSCD. 3D analysis showed a 46% increase in long nerves only in mild LSCD ( P < 0.01). This proof-of-concept study validates the use of 3D reconstruction to better characterize the corneal subbasal nerve in eyes with LSCD. In the future, this concept could be used with machine learning to automate the measurements.

Impact of annual trend volume of low-dose computed tomography for lung cancer screening on overdiagnosis, overmanagement, and gender disparities

BackgroundWith the increasing prevalence of nonsmoking-related lung cancer in Asia, Asian countries have increasingly adopted low-dose computed tomography (LDCT) for lung cancer screening, particularly in private screening programs. This study examined how annual LDCT volume affects lung cancer stage distribution, overdiagnosis, and gender disparities using a hospital-based lung cancer database.MethodsThis study analyzed the annual utilized LDCT volume, clinical characteristics of lung cancer, stage shift distribution, and potential overdiagnosis. At the individual level, this study also investigated the relationship between stage 0 lung cancer (potential strict definition regarding overdiagnosis) and the clinical characteristics of lung cancer.ResultsThis study reviewed the annual trend of 4971 confirmed lung cancer cases from 2008 to 2021 and conducted a link analysis with an LDCT imaging examination database over these years. As the volume of lung cancer screenings has increased over the years, the number and proportion of stage 0 lung cancers have increased proportionally.Our study revealed that the incidence of stage 0 lung cancer increased with increasing LDCT scan volume, particularly during the peak growth period from 2017 to 2020. Conversely, stage 4 lung cancer cases remained consistent across different time intervals. Furthermore, the increase in the lung cancer screening volume had a more pronounced effect on the increase in stage 0 lung cancer cases among females than it had among males. The estimated potential for overdiagnosis brought about by the screening process, compared to non-participating individuals, ranged from an odds ratio of 7.617 to one of 17.114. Both strict and lenient definitions of overdiagnosis (evaluating cases of stage 0 lung cancer and stages 0 to 1 lung cancer) were employed.ConclusionsThese results provide population-level evidence of potential lung cancer overdiagnosis in the Taiwanese population due to the growing use of LDCT screening, particularly concerning the strict definition of stage 0 lung cancer. The impact was greater in the female population than in the male population, especially among females younger than 40 years.To improve lung cancer screening in Asian populations, creating risk-based prediction models for smokers and nonsmokers, along with gender-specific strategies, is vital for ensuring survival benefits and minimizing overdiagnosis.

Multimodal Imaging of Optic Nerve Head in Retinitis Pigmentosa

ABSTRACT Background A pallor optic nerve head (ONH) is one of the three features of retinitis pigmentosa (RP). This study aimed to assess the ONH prospectively by color tone, presence of hyper-reflective tissue, blood flow, retinal nerve fiber layer (RNFL) thickness, ganglion cell complex (GCC) and investigate the change in these parameters with and without ONH pallor. Methods The presence of ONH pallor was assessed by three independent examiners through careful examination using fundus photographs. The presence of a hyper-reflective structure on the ONH was carefully evaluated using a volume scan optical coherence tomography (OCT). RNFL thickness and ellipsoid zone (EZ) width around the macula were also evaluated by OCT. Laser speckle flowgraphy was used to measure the mean blur rate of the entire ONH area, which was subsequently divided into the vessel area (MV) and tissue area (MT). Results Twenty-eight eyes of 28 patients with RP (55.4 ± 16.23 years of age) were included. The pale ONH was observed in 10 (35%) eyes. Hyper-reflective structures were observed in seven (25%) eyes. No significant correlation was found between the pale ONH and the presence of a hyper-reflective structure (Pearson’s chi-squared test, p = .364). The average of the ONH area, MV, and MT was 8.65 ± 3.08 AU, 17.81 ± 7.54 AU, and 6.4 ± 2.66 AU, respectively, which significantly decreased in patients with pallor ONH (all p < .05). The global RNFL thickness was 73.54 ± 18.82 μm. The nasal and superior quadrants and global RNFL thickness in patients with a pale ONH were significantly thinner than in patients without a pale ONH (all p < .05). The global and superior and inferior GCC thickness in patients with a pale ONH were significantly thinner than in patients without a pale ONH(all p < .05).There was no difference in the EZ width between patients with and without a pale ONH (p = .107). Conclusion We conducted multiple assessments of the ONH in RP patients and investigated its clinical significance. Our findings suggest that ONH pallor may indicate a comprehensive change that emerges alongside the progression of retinal degeneration in RP. Trial registration This trial was retrospectively registered in the UMIN Clinical Trial Registry (UMIN ID: 000048168).

Structures and Backscattering Characteristics of CUSAT 205 MHz Stratosphere‐Troposphere Radar at Cochin (10.04°N, 76.3°E)—First Results

AbstractThis paper presents the first ever observations on aspect‐sensitive characteristics of 205 MHz stratosphere–troposphere (ST) radar located at a tropical station Cochin (10.04°N, 76.3°E) using volume scanning. The most significant and new observation is that the signal‐to‐noise ratio in zenith and off‐zenith beams are nearly equal in some height region, indicating the presence of isotropic turbulence. Signal strength decreases by 0.75 dB per degree from 0 to 10 degree off‐zenith, 0.9 dB per degree from 10 to 20 degree off‐zenith and 0.3 dB per degree beyond 20 degree off‐zenith. Different causative mechanisms are discussed on the basis of various estimated parameters associated with aspect sensitivity. Maximum aspect sensitivity is observed between 12 and 17 km, indicating the presence of dynamic instability arising due to strong wind shear and atmospheric stability. When both the square of wind shear and stability parameters are above 0.25 × 10−3 s−2, the scatterers become mostly isotropic. The study also shows a power difference in the symmetric beams as well as azimuth angle dependency. Analysis suggests that this asymmetry is due to the tilting of layers by the action of atmospheric gravity waves generated through Kelvin‐Helmholtz instability. The present configuration of radar can provide a better understanding of three‐dimensional structures of turbulence and instabilities.

The Improvement of Short-Term Quantitative Precipitation Forecast in Mountainous Areas by the Assimilation of Meteorological State Variables Retrieved by Multiple Doppler Radar Data

Abstract This study presents a sequential procedure formulated by combining a multiple-Doppler radar wind synthesis technique with a thermodynamic retrieval method, which can be applied to retrieve the three-dimensional wind, pressure, temperature, rainwater mixing ratio, and moisture over complex terrain. The retrieved meteorological state variables are utilized to reinitialize a high-resolution numerical model, which then carries out time integration using four different microphysical (MP) schemes, including the Goddard Cumulus Ensemble (GCE), Morrison (MOR), WRF single-moment 6-class (WSM6), and WRF double-moment 6-class (WDM6) schemes. It is found that through this procedure, the short-term quantitative precipitation forecast (QPF) skill of a numerical model over mountainous areas can be significantly improved up to 6 h. The moisture field plays a crucial role in producing the correct rainfall forecast. Since no specific microphysical scheme outperforms the others, a combination of various rainfall scenarios forecasted by different MP schemes is suggested in order to provide a stable and reliable rainfall forecast. This work also demonstrates that, with the proposed approach, radar data from only two volume scans are sufficient to improve the rainfall forecasts. This is because the unobserved meteorological state variables are instantaneously retrieved and directly used to reinitialize the model, thereby the model spinup time can be effectively shortened.

Intraretinal Hyper-Reflective Foci Are Almost Universally Present and Co-Localize With Intraretinal Fluid in Diabetic Macular Edema.

In diabetic macular edema (DME), hyper-reflective foci (HRF) has been linked to disease severity and progression. Using an automated approach, we aimed to investigate the baseline distribution of HRF in DME and their co-localization with cystoid intraretinal fluid (IRF). Baseline spectral-domain optical coherence tomography (SD-OCT) volume scans (N = 1527) from phase III clinical trials YOSEMITE (NCT03622580) and RHINE (NCT03622593) were segmented using a deep-learning-based algorithm (developed using B-scans from BOULEVARD NCT02699450) to detect HRF. The HRF count and volume were assessed. HRF distributions were analyzed in relation to best-corrected visual acuity (BCVA), central subfield thickness (CST), and IRF volume in quartiles, and Diabetic Retinopathy Severity Scores (DRSS) in groups. Co-localization of HRF with IRF was calculated in the central 3-mm diameter using the en face projection. HRF were present in most patients (up to 99.7%). Median (interquartile range [IQR]) HRF volume within the 3-mm diameter Early Treatment Diabetic Retinopathy Study ring was 1964.3 (3325.2) pL, and median count was 64.0 (IQR = 96.0). Median HRF volumes were greater with decreasing BCVA (nominal P = 0.0109), and increasing CST (nominal P < 0.0001), IRF (nominal P < 0.0001), and DRSS up to very severe nonproliferative diabetic retinopathy (nominal P < 0.0001). HRF co-localized with IRF in the en face projection. Using automated HRF segmentation of full SD-OCT volumes, we observed that HRF are a ubiquitous feature in DME and exhibit relationships with BCVA, CST, IRF, and DRSS, supporting a potential link to disease severity. The spatial distribution of HRF closely followed that of IRF.

A step towards 6D WAXD tensor tomography.

X-ray scattering/diffraction tensor tomography techniques are promising methods to acquire the 3D texture information of heterogeneous biological tissues at micrometre resolution. However, the methods suffer from a long overall acquisition time due to multi-dimensional scanning across real and reciprocal space. Here, a new approach is introduced to obtain 3D reciprocal information of each illuminated scanning volume using mathematic modeling, which is equivalent to a physical scanning procedure for collecting the full reciprocal information required for voxel reconstruction. The virtual reciprocal scanning scheme was validated by a simulated 6D wide-angle X-ray diffraction tomography experiment. The theoretical validation of the method represents an important technological advancement for 6D diffraction tensor tomography and a crucial step towards pervasive applications in the characterization of heterogeneous materials.

Intravital Imaging of the Human Cornea Reveals the Differential Effects of Season on Innate and Adaptive Immune Cell Morphodynamics

Defining how the invivo immune status of peripheral tissues is shaped by the external environment has remained a technical challenge. We recently developed Functional invivo confocal microscopy (Fun-IVCM) for dynamic, longitudinal imaging of corneal immune cells in living humans. This study investigated the effect of seasonal-driven environmental factors on the morphodynamic features of human corneal immune cell subsets. Longitudinal, observational clinical study. Sixteen healthy participants (aged 18-40 years) attended 2 visits in distinct seasons in Melbourne, Australia (Visit 1, November-December 2021 [spring-summer]; Visit 2, April-June 2022 [autumn-winter]). Environmental data were collected over each period. Participants underwent ocular surface examinations and corneal Fun-IVCM (Heidelberg Engineering). Corneal scans were acquired at 5.5 ± 1.5-minute intervals for up to 5 time points. Time-lapse Fun-IVCM videos were created to analyze corneal immune cells, comprising epithelial T cells and dendritic cells (DCs), and stromal macrophages. Tear cytokines were analyzed using a multiplex bead-based immunoassay. Difference in the density, morphology, and dynamic parameters of corneal immune cell subsets over the study periods. Visit 1 was characterized by higher temperature, lower humidity, and higher air particulate and pollen levels compared with Visit 2. Clinical ocular surface parameters and the density of immune cell subsets were similar across visits. At Visit 1 , corneal epithelial DCs were larger, with a lower dendrite probing speed (0.38 ± 0.21 vs. 0.68 ± 0.33 μm/min; P < 0.001) relative to Visit 2; stromal macrophages were more circular and had less dynamic activity (Visit 1, 7.2 ± 1.9 vs. Visit 2, 10.3 ± 3.7 dancing index; P < 0.001). Corneal T cell morphodynamics were unchanged across periods. Basal tear levels of interleukin 2 and CXCL10 were relatively lower during spring-summer. This study identifies that the invivo morphodynamics of innate corneal immune cells (DCs, macrophages) are modified by environmental factors, but such effects are not evident for adaptive immune cells (T cells). The cornea is a potential invivo window to investigate season-dependent environmental influences on the human immune system. Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

Development and validation of a reliable method for automated measurements of psoas muscle volume in CT scans using deep learning-based segmentation: a cross-sectional study

ObjectivesWe aimed to develop an automated method for measuring the volume of the psoas muscle using CT to aid sarcopenia research efficiently.MethodsWe used a data set comprising the CT scans...

Writing and publishing papers in academic radiology: Why it needs to be more than a box checked for promotion

An ongoing challenge in academic radiology is balancing the need to read the scans and generate relative value units (RVUs) with the need to ensure academic leadership and the consistent production of impactful publications. Indeed, the tripartite mission of academic radiology (i.e. clinical care, research, and teaching) does not lend itself to obvious answers in an era when institutions and departments are increasingly focused on RVU generation. Even the minority of radiologists who are interested in pursuing the academic mission and accept academic jobs are likely to find their time increasingly squeezed by massive volumes of scans to read and the priority placed on RVU generation. There are often no incentives for impactful academic work, leading to a decreasing relative number of manuscript submissions from U.S.-based researchers. With the lack of external incentivization for publication, writing and publishing papers must instead be driven by intrinsic enjoyment and a sense of accomplishment. The ability to think of an idea, to get a group of co-authors together, to acquire the data and/or put together the idea into a form that is ready for final publication, and to see that process through to the end is rewarded only by personal satisfaction. Perhaps, in the era of RVU generation, publishing papers in a form of defiance of a system that is hampering the academic mission.