Increase In Volume Research Articles

Biological sex and BMI influence the longitudinal evolution of adolescent and young adult MRI-visible perivascular spaces.

An association recently emerged between magnetic resonance imaging (MRI)-visible perivascular spaces (MV-PVS) with intracerebral solute clearance and neuroinflammation, in adults. However, it is unknown how MV-PVS change throughout adolescence and what factors influence MV-PVS volume and morphology. This study assesses the temporal evolution of MV-PVS volume in adolescents and young adults, and secondarily evaluates the relationship between MV-PVS, age, sex, and body mass index (BMI). This analysis included a 783 participant cohort from the longitudinal multicenter National Consortium on Alcohol and Neurodevelopment in Adolescence study that involved up to 6 imaging visits spanning 5 years. Healthy adolescents aged 12-21 years at study entry with at least two MRI scans were included. The primary outcome was mean MV-PVS volume (mm 3 /white matter cm 3 ). On average, males had greater MV-PVS volume at all ages compared to females. A linear mixed-effect model for MV-PVS volume was performed. Mean BMI and increases in a person's BMI were associated with increases in MV-PVS volume over time. In females only, changes in BMI correlated with MV-PVS volume. One unit increase in BMI above a person's average BMI was associated with a 0.021 mm 3 /cm 3 increase in MV-PVS volume (p<0.001). This longitudinal study showed sex differences in MV-PVS features during adolescence and young adulthood. Importantly, we report that increases in BMI from a person's mean BMI are associated with increases in MV-PVS volume in females only. These findings suggest a potential link between MV-PVS, sex, and BMI that warrants future study.

Interface Dynamics at a Four-Fluid Interface during Droplet Impact on a Two-Fluid System.

We investigate the interfacial dynamics involved in the impact of a droplet on a liquid-liquid system, which involves the impingement of an immiscible core liquid drop from a vertical separation onto an interfacial shell liquid layer floating on a host liquid bath. The dynamics have been studied for a wide range of impact Weber numbers and two different interfacial shell liquids of varying volumes. The core drop, upon impact, dragged the interfacial liquid into the host liquid, forming an interfacial liquid column with an air cavity inside the host liquid bath. The dynamics is resolved into cavity expansion and rapid contraction, followed by thinning of the interfacial liquid. The interplay of viscous dissipation, interfacial pull, and core drop inertia influenced the necking dynamics. The viscous dissipation increases with the thickness of the interfacial layer, which depends on the volume and lateral spread over the water. The necking dynamics transitioned from inertia-dominated deep seal closure at higher spread, lower interfacial film volumes, and higher Weber numbers into inertia-capillary-dominated deep seal closure with an increase in film volumes, decrease in the spread of the interfacial fluid, or decrease in Weber number and finally into a no-seal closure at high volumes, low spread, and low Weber numbers.

Hofmann Clathrates: A "Blue Box" Approach to Modulate Spin-Crossover Properties.

Hofmann coordination polymers (CPs) with cationic ligands provide an innovative strategy for recognizing p-electron-rich aromatic molecules - similar to the "little blue box". In this study, we demonstrate that hydroquinone molecules can be incorporated into these coordination polymers when redox-active bipyridinium derivatives are used as axial ligands. The insertion leads to a significant structural modification, resulting in a shift of the spin transition by 150 K and an approximate 23% increase in volume, caused by the strong donor-acceptor p-p stacking interaction formed between the ligands and the guest molecule. These findings have been confirmed through temperature-dependent single crystal X-ray diffraction, magnetic measurements and optical reflectivity measurements.

Can a nature walk change your brain? Investigating hippocampal brain plasticity after one hour in a forest

In cities, the incidence of mental disorders is higher, while visits to nature have been reported to benefit mental health and brain function. However, there is a lack of knowledge about how exposure to natural and urban environments affects brain structure. To explore the causal relationship between exposure to these environments and the hippocampal formation, 60 participants were sent on a one hour walk in either a natural (forest) or an urban environment (busy street), and high-resolution hippocampal imaging was performed before and after the walks. We found that the participants who walked in the forest had an increase in subiculum volume, a hippocampal subfield involved in stress response inhibition, while no change was observed after the urban walk. However, this result did not withstand Bonferroni correction for multiple comparisons. Furthermore, the increase in subiculum volume after the forest walk was associated with a decrease in self-reported rumination. These results indicate that visits to nature can lead to observable alterations in brain structure, with potential benefits for mental health and implications for public health and urban planning policies.

Mice lacking Astn2 have ASD-like behaviors and altered cerebellar circuit properties

Astrotactin 2 (ASTN2) is a transmembrane neuronal protein highly expressed in the cerebellum that functions in receptor trafficking and modulates cerebellar Purkinje cell (PC) synaptic activity. Individuals with ASTN2 mutations exhibit neurodevelopmental disorders, including autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), learning difficulties, and language delay. To provide a genetic model for the role of the cerebellum in ASD-related behaviors and study the role of ASTN2 in cerebellar circuit function, we generated global and PC-specific conditional Astn2 knockout (KO and cKO, respectively) mouse lines. Astn2 KO mice exhibit strong ASD-related behavioral phenotypes, including a marked decrease in separation-induced pup ultrasonic vocalization calls, hyperactivity, repetitive behaviors, altered behavior in the three-chamber test, and impaired cerebellar-dependent eyeblink conditioning. Hyperactivity and repetitive behaviors are also prominent in Astn2 cKO animals, but they do not show altered behavior in the three-chamber test. By Golgi staining, Astn2 KO PCs have region-specific changes in dendritic spine density and filopodia numbers. Proteomic analysis of Astn2 KO cerebellum reveals a marked upregulation of ASTN2 family member, ASTN1, a neuron-glial adhesion protein. Immunohistochemistry and electron microscopy demonstrate a significant increase in Bergmann glia volume in the molecular layer of Astn2 KO animals. Electrophysiological experiments indicate a reduced frequency of spontaneous excitatory postsynaptic currents (EPSCs), as well as increased amplitudes of both spontaneous EPSCs and inhibitory postsynaptic currents in the Astn2 KO animals, suggesting that pre- and postsynaptic components of synaptic transmission are altered. Thus, ASTN2 regulates ASD-like behaviors and cerebellar circuit properties.

Mechano-chemical, high-consistency activation of kraft pulp in deep eutectic solvent of choline chloride and urea

Deep eutectic solvents (DESs) offer an appealing green medium for the activation of cellulose fibres to promote their swelling, reactivity, hydrolysis, disintegration, and solubility for further processing. Typically, DES treatments are carried out below 5 wt% consistency even though a higher solids content could enhance the fibre activation and reduce the solvent consumption. In this work, a high-consistency (HC) mechano-chemical activation of bleached softwood kraft pulp was elucidated using a simultaneous fibre treatment with DES of choline chloride-urea and a sigma-type kneader or a twin-screw extruder at a solids content of 15–35 wt% and 30 wt%, respectively. Both HC treatments efficiently triggered fibre swelling, which was indicated by an increase in the fibre width, and loosened the cell wall structure which was indicated by an increase in the mesopore volume. Mechano-chemical HC processing generated fibre fines and external fibrillation, while the molecular-level structural alteration or changes in chemical composition were minor; the intrinsic viscosity and the crystallinity of the pulp remained at their initial level and only a small amount of xylan was dissolved. Overall, HC treatment in a twin-screw extruder caused notably more severe morphological changes in the fibres than batch treatment in a sigma-type kneader. Thus, the mechano-chemical HC treatment with DES provides an industrially relevant technology for cellulose modification and opens possibilities to enhance heterogeneous cellulose modification processes in which the highly available surface area of pulp is a key parameter.

Experimental study on in-situ emulsification of heavy oil in porous media

Under the strategic goal of “dual-carbon”, reducing oil viscosity by in-situ emulsification using chemical method has become a new direction for high-efficiency and low-carbon development of heavy oil reservoirs. This technology can transform the originally immovable heavy oil into movable dispersed oil droplets through in-situ emulsification, and thus enhances heavy oil recovery. However, there is still a lack of sufficient understanding about the characteristics and influencing laws of in-situ emulsification of heavy oil in porous media. So, this paper carried out experimental studies on in-situ emulsification and influencing factors for heavy oil in porous media. The results show that, due to the transport and adsorption loss of viscosity reducer in porous media, the emulsification area expands gradually from the inlet to the outlet. At the same sampling position, with the increase of injection volume, the dispersed oil droplet size decreases, the distribution density increases, and the color of produced liquid changes from light yellow to dark brown. Under the same injection volume, the closer to the outlet, the smaller the particle size of the dispersed oil droplets and the higher the distribution density, which is resulted from the shearing effect of the porous media. With the increase of injection rate, the hydrodynamic shear effect is enhanced, so the in-situ emulsification of heavy oil starts earlier and the emulsification oil ratio curves have a higher slope and distribute more densely. With the increase of agent concentration, the adsorbed number of viscosity reducer molecules on the oil–water interface is increased, making it easier to emulsify the remaining oil. With the increase of pre-conversion oil recovery, the remaining oil in the porous media is more dispersed and the oil–water contact surface increases, so the emulsification is easier and the percentage of dispersed oil droplets in the produced oil phase increases. The research results based on sampling analysis deepen our understanding on in-situ emulsification of heavy oil in porous media, which provides valuable reference for designing suitable viscosity reducer agent and effectively enhancing heavy oil recovery in the future.

Ignition and flow combustion characteristics of hydroxylammonium nitrate - based liquid propellant based on electric method

Hydroxylamine nitrate (HAN)-based liquid propellants are characterized by high energy content and low toxicity ionic monopropellants, offering great potential application prospects in the space engine. This paper proposes an experimental system for electric ignition and combustion of HAN-based liquid propellant. The energy for decomposition, current, and combustion image of HAN-based liquid propellant are measured under different initial voltage, propellant volume, and the initial pressures in Ar and air atmospheres. The results show that the energy for decomposition decreased with an increase in initial voltage, propellant volume, and initial pressure. An increase in the initial voltage accelerates the reaction speed of HAN-based liquid propellant, and the energy for decomposition is approximately 3 J. An increase in the propellant volume decreases the equivalent resistance in the circuit, increasing the current and enhancing the thermal effect of the propellant. The accumulation of decomposition products and heat under high pressure reduced the energy for decomposition; the energy for decomposition is less than 1.5 J for the pressurization condition. Compared with the Ar atmosphere, the energy for decomposition of HAN-based liquid propellant shows better stability in the air atmosphere. The flow combustion device of HAN-based liquid propellant for the flow state is designed. The HAN-based liquid propellant is successfully ignited for different initial voltages and flow rates. The research results provide a reference for the design of space engine for HAN-based liquid propellant based on the electric ignition method.

To Shrink or Not to Shrink? An Objective Assessment of Free Gracilis Muscle Volume Change in Lower-Extremity Defect Reconstruction.

Background: The use of free gracilis muscle flaps in reconstructive surgery of the lower leg is common practice to cover defects. However, there is still a lack of understanding of the morphometric changes that occur in the transferred muscle and area of interest over time, particularly the characteristic volume decrease that is observed over the course of the first year. This study aimed to assess volume changes in patients with free gracilis muscle flap reconstruction following infection, trauma, or malignancies of the lower extremity. Methods: Three-dimensional surface imaging was performed intraoperatively after 2 weeks, 6 months, and 12 months with the Vectra H2 system. A total of 31 patients were included in this study and analyzed. Results: There was an average volume increase of 146.67 ± 29.66% 2 weeks after reconstruction. Compared to this volume increase, there was a reduction of 108.44 ± 13.62% after 12 months (p < 0.05). Overall, we found a shrinkage to 85.53 ± 20.14% of the intraoperative baseline volume after 12 months. Conclusions: The use of non-invasive 3D surface imaging is a valuable tool for volume monitoring after free flap reconstruction of the lower extremity. The free gracilis muscle flap undergoes different phases of volume change over the first year, with the greatest influence on overall change being the development and decongestion of edema. Precise initial surgical tailoring is crucial for optimal long-term functional and cosmetic results.

Optical coherence tomography angiography in neovascular age-related macular degeneration: comprehensive review of advancements and future perspective.

Optical coherence tomography angiography (OCTA) holds promise in enhancing the care of various retinal vascular diseases, including neovascular age-related macular degeneration (nAMD). Given nAMD's vascular nature and the distinct vasculature of macular neovascularization (MNV), detailed analysis is expected to gain significance. Research in artificial intelligence (AI) indicates that en-face OCTA views may offer superior predictive capabilities than spectral domain optical coherence tomography (SD-OCT) images, highlighting the necessity to identify key vascular parameters. Analyzing vasculature could facilitate distinguishing MNV subtypes and refining diagnosis. Future studies correlating OCTA parameters with clinical data might prompt a revised classification system. However, the combined utilization of qualitative and quantitative OCTA biomarkers to enhance the accuracy of diagnosing disease activity remains underdeveloped. Discrepancies persist regarding the optimal biomarker for indicating an active lesion, warranting comprehensive prospective studies for validation. AI holds potential in extracting valuable insights from the vast datasets within OCTA, enabling researchers and clinicians to fully exploit its OCTA imaging capabilities. Nevertheless, challenges pertaining to data quantity and quality pose significant obstacles to AI advancement in this field. As OCTA gains traction in clinical practice and data volume increases, AI-driven analysis is expected to further augment diagnostic capabilities.

Evaluation of Minimum Axial Airway Area and Airway Volume in Orthognathic Surgery Patients: A Retrospective Study.

The aim of this study was to compare preoperative and postoperative linear, planar, and volumetric measurements in the pharyngeal airway in orthognathic surgery patients. Preoperative and postoperative cone beam computed tomography (CBCT) images of 60 patients, who underwent maxillary advancement with mandibular setback (Group I, n=25) and bimaxillary advancement (Group II, n=35), were compared. The airway was divided into 3 regions as nasopharynx, oropharynx, and hypopharynx. Linear and planar measurements were made on the reference sections of each region. The minimum axial airway area, the volume of 3 regions, and total airway volume were also measured. Regarding the linear, planar, and volumetric measurements, while there was a statistically significant increase in the measurements for all three regions in Group II, in Group I only the measurements in the nasopharyngeal region demonstrated a statistically significant increase postoperatively (P<0.05). There was an increase in minimum axial airway areas in both groups; however, it was only statistically significant in Group II (P<0.05). There was a statistically significant increase in total airway volumes in both groups (P<0.05). A positive and good correlation was found between the percent increase in the minimum axial area and the percent increase in the total volume (P<0.05). While bimaxillary advancement surgery results in a significant increase in the pharyngeal airway, mandibular setback with maxillary advancement caused an increase in the total airway. Changes that may occur in the airway should be considered while planning orthognathic surgery.

The Effect of Promotions and Buying Interest on Increasing Product Sales Volume at PT. Indosat TBK Manado Branch

The aim of this study is to ascertain how buying interest and promotions affect the volume of products sold at the PT. Indosat Tbk Manado Branch. The research approach makes use of quantitative techniques. 75,910 Indosat users in Manado City as of July 30, 2021, make up the study's population. Using the Slovin formula method, the author calculated the sample size, which came out to be 100 respondents. The regression equation is as follows, based on the research findings: Y = 2.140 + 0.417X1 + 0.378X2 + e. The t test computation's results indicate that there is a partial positive relationship between the Promotion variable (X1) and rising sales volume (Y). Partially contributing to the increase in sales volume (Y) is the Buying Interest variable (X2).

Development and application of closed-loop-oriented intelligent control system for blast furnace air volume addition or reduction

Adjusting the upper and lower parts is an important means to ensure stable operation of blast furnaces. It is a common operation method to adjust the smelting state of the blast furnace by adjusting the air volume. Most of the domestic blast furnace air volume increase and decrease operations are confirmed by manual experience, and it is difficult to realize intelligent automatic control. This paper presents an intelligent control system for regulating air volume in blast furnaces, based on operational logic, expert knowledge, fundamental theories, and other relevant information. The system enables automatic analysis of the blast furnace's state and intelligent reasoning of the foreman's operational methods, laying the foundation for achieving closed-loop control. The system unifies the control philosophy and stabilizes the control methods for regulating air volume in blast furnaces. This achieves standardization of operation and proceduralization of cause analysis. The system enhances adaptability by creating an information feedback mechanism, increasing acceptance among blast furnace operators, and continuously resolving various anomalies in practical applications. The system currently maintains a true hit rate of over 95%, enabling effective reduction of operational misjudgments, intelligent control of airflow adjustment, and promotion of stable and smooth blast furnace operation.

Rising rates of anterior cruciate ligament reconstruction in Australian adults: An analysis of Australian Medicare Benefits Schedule database.

Anterior cruciate ligament (ACL) reconstruction is an evolving field, though there remains sparse epidemiological data on the treatment of ACL ruptures. The objective of this study is to analyse the trends in the rate of ACL reconstruction (ACLR) in adult patients over the past two decades in the Australian population. The incidence of ACLR between 2001 and 2020 in patients 15 years and over was analysed using the Australian Medicare Benefits Schedule (MBS) database. The data reflect patients with private health coverage (45% of the Australian population).An offset term was introduced using national population data to account for population changes over the study period. A total of 160,353 ACLRs were performed in Australia under the MBS in the 20-year period from 2001 to 2020. An annual increase in the total volume and per capita rate of ACLRs was found (p < 0.05). The annual volume of cases increased by 82%, from 5512 in 2001 to a peak of 10,011 in 2017. This increase was seen across all age groups (p < 0.05) and both sexes (p < 0.05), with a greater proportion of reconstructions performed on males (n = 102,357, 64%) than females (n = 57,996, 36%). In 2020, the rate of adult ACLRs decreased to a level last seen in 2004, likely due to the effects of COVID-19. The incidence of ACLR in adult patients has increased in Australia over the 20-year study period. The trends noted provide information that can be used to guide resource allocation and health provision in the future. Level IV.

Energy consumption and dilution of toxic gases in underground infrastructures: A case study in a railway tunnel under forced ventilation

Toxic fumes are released after blasting in underground excavations. The analysis of safe re-entry times into the work areas is essential for addressing safety and productivity concerns. In this paper, a railway tunnel 2.1 km long under forced ventilation system is selected as a case study to assess the energy consumption and re-entry times after blasting under different ventilation conditions. First, three-dimensional CFD numerical models were conducted in order to predict the migration time to reduce the levels of noxious gases below the limits established in safety regulations. Field measurements were conducted to verify the accuracy of the results obtained in the simulations. Then, additional analytical models were conducted to evaluate the energy consumed by the ventilation system. The results obtained show that the accumulated re-entry time reaches 414 h for the excavation of the tunnel employing an airflow rate of 40 m3 s−1. This time increases by 33 % when the airflow rate decreases to 30 m3 s−1. However, even though the time decreases when the ventilation volume increases, energy consumption increases significantly, reaching 1,306 MWh for a ventilation volume of 40 m3 s−1 compared to 551 MWh using an airflow of 30 m3 s−1.

Chronic systolic heart failure: association of remodeling of the right heart and renal dysfunction with cardiac arrhythmias

Introduction. Ischemic (ICMP) and dilated cardiomyopathy (DCMP) are the leading causes of chronic heart failure (CHF) with the most frequent indication for heart transplantation. The similarity of these diseases consists in the widespread and high mortality rate due to pathological remodeling of both the left and right chambers of the heart, which is accompanied by the progression of CHF, increasing the risk of sudden cardiac death.The purpose of the study. To study the relationship of systolic function of the left ventricle (LV) with remodeling of the right heart, renal dysfunction and their relationship with cardiac arrhythmia.Materials and methods. The study included 72 patients with CHF with reduced ejection fraction (CHFrEF), who were being treated at the N. V. Sklifosovsky Scientific Research Institute of EM in connection with worsening CHF. Group I consisted of 48 patients with DCMP; group II – 24 patients with ICMP.Results. LV ejection fraction (LV EF) in patients of both groups was &lt;30 %, but it was significantly lower in group I (p=0.001). The EF of the right ventricle (RV) in group I was low and amounted to 24.6 [19.5; 28.5]%. In group I, the volume of the right atrium (PP) and the size of the pancreas correlated with LV EF (r= –0.489, p=0.015 and r= –0.410, p=0.005, respectively); each subsequent increase in the volume of right atrium (RA) by 1 ml increased the likelihood of atrial fibrillation (AF) by 1.018 times (OR: 1.018, 95 % CI: 1.0042–1.033, p=0.011). The estimated glomerular filtration rate (eGFR) &lt;60 ml/min/1.73 m2 increased the chances of ventricular tachycardia (VT) by 9.5 times (OR: 9.5, 95 % CI: 2.32–38.87, p=0.002). Each subsequent decrease in eGFR by 1 ml/min/1.73 m2 increased the chances of developing VT by 1.03 times (OR: 0.967, 95 % CI: 0.937–0.988, p=0.036)].Conclusions. In patients with CHFrEF, regardless of the etiology, a decrease in LV EF leads to structural and functional changes in the right parts of the heart. In individuals with DCMP, an increase in RA volume by 1 ml increases the likelihood of AF by 1.018 times; a decrease in eGFR by 1 ml/min/1.73 m2 increases the chances of developing VT by 1.03 times.

Chemical Composition Analysis and Assessment of Antioxidant and Anti-Inflammatory Activities of Crude Extract of Flueggea leucopyrus on Carrageenan-Induced Paw Edema in Wistar Albino Rats.

A member of the Phyllanthaceae family, Flueggea leucopyrus is a well-known plant in the tribal areas of Sri Lanka, India's Shaurastra region, Australia, and Malaysia. This study provides information about Flueggea leucopyrus, a plant with a wide range of therapeutic uses in India. Different extracts from the leaves and roots of Flueggea leucopyrus were evaluated for their physical and chemical properties, preliminary phytochemical parameters, and pharmacological activities in the current study, followed by their fourier transform infrared spectroscopy (FTIR), gas chromatography-mass spectrometry (GC-MS), antioxidant, and anti-inflammatory properties. The aqueous extract of Flueggea leucopyrus leaves and roots have more different phytochemical elements than other solvent extracts, according to physico-chemical tests and phytochemical screening. As a result, the FT-IR, GC-MS, antioxidant, and anti-inflammatory activities of an aqueous extract were tested. Studies on hind paw edemas caused by carrageenan in albino rats examined the mean increase in paw volume and the percentage inhibition in paw volume at various time points following the injection of carrageenan (1% w/v). In comparison to the norm, these inhibitions were statistically significant (p < 0.001). The aqueous extract of Flueggea leucopyrus leaves and roots have both antioxidative and anti-inflammatory activities, indicating that it has the potential to be used in the formulation of antioxidant and anti-inflammatory medications in the future.

Co-Digestion and Mono-Digestion of Sewage Sludge and Steam-Pretreated Winter Wheat Straw in Continuous Stirred-Tank Reactors—Nutrient Composition and Process Performance

Wheat straw (WS) constitutes a considerable biomass resource and can be used to produce the energy carrier methane through anaerobic digestion. Due to the low contents of several nutrient elements and water in harvested WS, the use of sewage sludge (SS), consisting of primary sludge and waste-activated sludge, as a nutrient source in co-digestion with steam-pretreated wheat straw (PWS) was investigated theoretically and practically. WS was steam-pretreated, with acetic acid as the catalyst, at 190 °C for 10 min, ending with a rapid reduction in pressure. Process stability and specific methane production were studied for the mono-digestion and co-digestion of PWS and SS in continuous stirred-tank reactors for 208 days. The HRT was 22 days and the OLR 2.1 gVS L−1 d−1. In co-digestion, the OLR was increased to 2.8 gVS L−1 d−1 for one week. Nutrient elements were added to PWS mono-digestion at two different concentration levels. Co-digestion was stable, with a total concentration of short-chain fatty acids (SCFAs) at a safe level below 0.35 g L−1 at both OLRs. The higher OLR during co-digestion would require an increase in reactor volume of 14%, compared to the mono-digestion of SS, but would increase the annual production of methane by 26%. The specific methane production levels for PWS mono-digestion, SS mono-digestion, and co-digestion were 170, 320, and 260 mL g−1VS, respectively. Co-digestion did not result in a synergistic increase in the methane yield. SCFAs accumulated in the mono-digestion of PWS when using lower levels of nutrient supplements, and the concentrations fluctuated at higher nutrient levels. The main conclusion is that PWS and SS can be co-digested with long-term process stability, without the addition of chemicals other than water and acetic acid. The specific methane production for mono-digestion of PWS was relatively low. The effect of using higher concentrations of micronutrients in PWS mono-digestion should be evaluated in future studies.

Comparison of percutaneous microwave/radiofrequency ablation liver partition and portal vein embolization versus transarterial chemoembolization and portal vein embolization for planned hepatectomy with insufficient future liver remnant

BackgroundIn China, both percutaneous microwave/radiofrequency ablation liver partition plus portal vein embolization (PALPP) and transarterial chemoembolization (TACE) plus portal vein embolization (PVE) have been utilized in planned hepatectomy. However, there is a lack of comparative studies on the effectiveness of these two techniques for cases with insufficient future liver remnant (FLR).MethodsPatients were categorized into either the PALPP group or the TACE + PVE group. Clinical data, including FLR growth rate, complications, secondary resection rate, and overall survival rate, were compared and analyzed for both groups retrospectively.ResultsBetween December 2014 and October 2021, a total of 29 patients underwent TACE + PVE (n = 12) and PALPP (n = 17). In the TACE + PVE group, 7 patients successfully underwent two-stage hepatectomy, while in the PALPP group, 13 patients underwent the procedure (two-stage resection rate: 58.3% vs. 76.5%, P = 0.42). There were no significant differences in postoperative complications of one-stage procedures (11.8% vs. 8.3%, P > 0.05) and second-stage resection complication (0% vs. 46.2%, P = 0.05) between the TACE + PVE and PALPP groups. However, the PALPP group demonstrated a shorter time to FLR volume growth for second-stage resection (18.5 days vs. 66 days, P = 0.001) and KGR (58.5 ml/week vs. 7.7 ml/week, P = 0.001).ConclusionsCompared with TACE + PVE, PALPP results in a more significant increase in FLR volume and a higher rate of two-stage resection without increasing postoperative complications.

Enhancing PEMFC Performance: Optimization of Hot-Pressed Decal Transfer Conditions for MEA Fabrication

Proton exchange membrane fuel cells (PEMFCs) hold significant promise in curbing greenhouse gas emissions within the transportation sector. While historically more expensive than conventional internal combustion engines, the cost per kW is poised to significantly drop as production volumes increase and the adoption of fuel cell electric vehicles progresses [1]. In heavy-duty vehicle applications, predictions suggest that hydrogen fuel cells will achieve a cost equivalence with diesel, potentially becoming the most cost-effective option when evaluating the total ownership expenses [2]. Membrane-electrode-assemblies (MEAs) serve as the core of fuel cells, where all reactions—proton and electron generation, distribution, and consumption occur. Their efficiency dictates both cell performance and lifespan. Various methods for fabricating MEAs have been developed, including decal transfer, catalyst-coated membrane (CCM), and catalyst-coated gas diffusion layer (CCG) techniques. Among these, the decal transfer method is widely regarded as the most appropriate for large-scale production of MEAs [3]. This study delves into an examination of diverse hot-pressed decal transfer conditions for the preparation of MEAs tailored for PEMFC application. Our investigation involves fabricating MEAs through hot-press decal transfer at temperatures spanning 115°C to 145°C and pressures ranging from 200 psi to 400 psi, each held for a 5-minute duration. Electrochemical characterizations were performed within a single-cell setup to assess MEA performance. Moreover, an accelerated stress test (AST) was carried out to scrutinize the stability of the fabricated MEAs concerning their decal transfer conditions and morphological variations. Our study extensively explored catalyst layers transferred under diverse hot-pressed decal transfer conditions, focusing on their fuel cell performance and transport properties. To comprehensively understand the influence of morphological alterations on electrochemical characteristics, additional morphological characterizations, including white light interferometer (WLI) imaging, field emission scanning electron microscopy (FESEM), Brunauer-Emmett-Teller (BET) surface area analysis, and nano-computed tomography (Nano-CT) were employed for MEA evaluation. Our findings indicate that the MEA produced at 145°C and 200 psi exhibited superior performance in both pre- and post-AST testing. Comprehensive experimental results and insights will be elaborated upon during the conference presentation.