The article provides an overview of existing methods for assessing the level and quality of life of the population of the regions. A system of indicators has been formed to assess the standard of living, covering the level of poverty, inflation, unemployment, real incomes and food costs in the structure of consumer spending. The methodology was tested on the example of the regions of the Volga Federal District, the study period: 20202022. Regions were grouped according to the value of the integral index of living standards, regions with very high, high, medium, low and very low values of the integral indicator were identified. It is concluded that the standard of living is decreasing against the background of regional differentiation and the need to form a system of measures by public authorities aimed at improving the level and quality of life of the population. The practical significance of the results obtained is that they can be useful for making informed decisions in the field of regional policy and economics.