3D microstructures provide valuable insight into material behavior which is essential in elucidating microstructural phenomena, such as particle morphology and void damage, and consequent macroscopic material response. However, creating 3D microstructures is extremely laborious and expensive, requiring complex microstructural characterization and imaging techniques such as Focussed-Ion Beam based Scanning Electron Microscopy (FIB-SEM) or X-ray Computed Tomography (XCT). To this end, synthetic 3D microstructures were rapidly generated from orthogonal 2D images using SliceGAN, which proved a practical and cost-effective method. In this study, multiple synthetic microstructures of AA7075-O, a complex microstructure of various strengthening precipitates within a softer aluminum matrix, were post-processed, meshed, and modeled for different damage behavior in FEA using advanced constitutive material models. Subsequently, the synthetic and real microstructures were qualitatively and quantitatively analyzed for their elastoplastic deformation and ductile void damage responses.This study illustrates the viability of an integrated AI-FE methodology in studying microstructural micromechanics, demonstrating that synthetic microstructures exhibited a very similar stress-strain response, especially when using a free boundary condition, and comparable stress distribution and void damage, albeit with some discrepancies. Also, it emphasizes the influence of particle morphology on strength and damage, where highly irregular particles play a dual role in increasing strain hardening by restricting matrix flow at the cost of increased ductile damage induced by decohered particles. Lastly, the more advanced FE models, with multiple voiding mechanisms, reduced the discrepancy between real and synthetic microstructures compared to simpler models
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