Introduction. Ukrainians have been living under martial law for the last two years. As a result of a constant stress, physical and especially mental health is affected. Сhronic stress can cause functional hyperprolactinemia, which is characterized by an increase of the level of prolactin in the blood. Elevated serum prolactin is a level that is > 25 ng/ml or 530 mIU/L, which affects the functioning of various levels of the reproductive system. The purpose of the study: to study the effectiveness of complex therapy of hyperprolactinemia in women of the Sumy region, which is associated with chronic stress against the background of armed aggression. Materials and methods. The study was conducted at the Municipal Non-Profit Enterprise "Clinical Maternity Hospital of the Blessed Virgin Mary" and the Municipal Non-Profit Enterprise "Central City Clinical Hospital". A comprehensive clinical and laboratory examination was carried out of 81 women of the Sumy region who had reproductive plans, aged from 22 to 39 years old, who were divided into the following clinical groups: I (main) group, which included 31 women – was prescribed anti-stress therapy, drugs with Vitex agnus castus and cognitive behavioral therapy with a psychotherapist. II (comparison) group – 28 women who received anti-stress therapy and drugs with Vitex agnus castus and III (control) group – healthy women (n = 22). Exclusion criteria were the age of the patients less than 22 and more than 39 years, pituitary tumor confirmed (using magnetic resonance imaging) at the time of the study, taking medications that could affect the results of the studied hormones. Research results. The analysis of the obtained prolactin level data indicated that in the majority of women from the study groups, the prolactin level was elevated within the range of 24–35 ng/ml. Before treatment, the average concentration of prolactin in patients of group I was 36.74±2.72 ng/ml (р<0,05), after 3 months, a decrease in concentration was noted to 20.54±1.74 ng/ml (p<0,05). In the comparison group, the average concentration of prolactin before treatment was 31.64±2.48 ng/ml (р<0,05), while after 3 months, it equaled 27.04±2.02 ng/ml (p<0,05). Also, in patients of the I group, the level of estradiol, progesterone and a thickness of the endometrium were increased. Conclusion. The scheme of a differentiated approach to the treatment of Sumy region women with hyperprolactinemia against the background of stress, which we have outlined, contributes to the normalization of prolactin, estrogen, progesterone levels, and the growth of the functional endometrial layer.