Due to the irreversible nature of the consequences of fire, fire protection is a major challenge and source of problems for all types of built heritage. This study aims to establish sustainable fire protection technology strategies by generalizing fire prevention and control technologies and measures against extended burns. This study aims to explore Macau’s industrial heritage’s historical development and technological applications in the field of fire protection using literature analysis, field investigation, and spatial information visualization methods. It will be carried out using the industrial heritage of Macau as the object and systematic analyses from the screening and processing of fire protection historical data, fire risk assessment, and the migration of fire protection focus. The results show that (1) the fire protection of the industrial heritage of Macau has gone through a total of three phases: passive fire protection, transition of fire protection methods, and active fire protection, and the relied-upon fire protection technologies have been iterated and renewed continuously during this period. (2) When the fire load factors of industrial heritage increase, the fire vulnerability assessment substantially changes, and the center of gravity of heritage fire protection shifts from controlling the scope of disaster to reducing the fire risk. (3) The construction of a suitable and effective ecological model of fire protection technology can provide appropriate fire protection solutions for the preservation and reuse of Macau’s industrial heritage in a complex cultural context. Therefore, this study will help to solve the current dilemma of sustainable application and development of fire protection technology for industrial heritage. This study hopes to provide ideas and strategies for reference on industrial heritage fire protection issues in the development of similar world heritage cities.