AbstractBackgroundPosterior cortical atrophy (PCA) is a clinico‐radiological syndrome mostly commonly underpinned by Alzheimer’s disease (AD) pathology and has been referred to as the most common atypical AD clinical phenotype. PCA consensus classification criteria emphasize core clinical and cognitive features comprising visual and other posterior features in contrast to relatively spared episodic memory, language, executive functions and behavior (Crutch et al., Alzheimers Dement., 2017). However, posterior features are less commonly evaluated in standard neuropsychological batteries compared to other domains, possibly contributing towards common diagnostic delays, and memory and executive function tests that have visual or numerical demands are particularly challenging in the evaluation of relatively spared functions. Standardization of the neuropsychological assessment of PCA is vital for multi‐center research collaborations, the development of outcome measures for future clinical trials, and better characterization of the extent of overlap with related neurodegenerative syndromes. Experts were surveyed regarding their practice preferences in the assessment of the PCA syndrome.MethodThe membership of the ISTAART Atypical Alzheimer’s Disease Professional Interest Area was invited to participate in a survey examining preferences for measures employed in the assessment of the visual and core cognitive features of PCA, as defined by the 2017 PCA consensus criteria.ResultAtypical AD PIA members included those with backgrounds in neurology, neuropsychology, psychiatry, geriatric medicine and clinical research (respondents N=55). Most commonly assessed features were space perception deficits, simultanagnosia and constructional apraxia, followed by dominant parietal features and alexia. Object perception deficits and early visual functions were less frequently assessed. A subset of respondents included preferred tests to evaluate global functioning and relatively spared features, including example measures less susceptible to visual dysfunction.ConclusionVariations in assessing PCA features are considered with implications for characterizing the extent of AD phenotypic heterogeneity, including proposed ventral and caudal PCA presentations. Results will inform future work to develop consensus recommendations for a short clinical PCA battery and an extended, formal PCA battery, in order to promote capacity for multi‐center studies and advance the development of appropriate outcome measures in trials enrolling patients with PCA and/or prominent posterior dysfunction.