Stroke-induced alteration in multi-layer information transmission of cortico-motor system during elbow isometric contraction modulated by myoelectric-controlled interfaces

Abstract

Objective. Human movement is a complex process requiring information transmission in inter-cortical, cortico-muscular and inter-muscular networks. Though motor deficits after stroke are associated with impaired networks in the cortico-motor system, the mechanisms underlying these networks are to date not fully understood. The purpose of this study is to investigate the changes in information transmission of the inter-cortical, cortico-muscular and inter-muscular networks after stroke and the effect of myoelectric-controlled interface (MCI) dimensionality on such information transmission in each network. Approach. Fifteen healthy control subjects and 11 post-stroke patients were recruited to perform elbow tracking tasks within different dimensional MCIs in this study. Their electromyography (EMG) and functional near-infrared spectroscopy (fNIRS) signals were recorded simultaneously. Transfer entropy was used to analyse the functional connection that represented the information transmission in each network based on the fNIRS and EMG signals. Main results. The results found that post-stroke patients showed the increased inter-cortical connection versus healthy control subjects, which might be attributed to cortical reorganisation to compensate for motor deficits. Compared to healthy control subjects, a lower strength cortico-muscular connection was found in post-stroke patients due to the reduction of information transmission following a stroke. Moreover, the increased MCI dimensionality strengthened inter-cortical, cortico-muscular and inter-muscular connections because of higher visual information processing demands. Significance. These findings not only provide a comprehensive overview to evaluate changes in the cortico-motor system due to stroke, but also suggest that increased MCI dimensionality may serve as a useful rehabilitation tool for boosting information transmission in the cortico-motor system of post-stroke patients.