Viscoelastic Changes Research Articles

Effect of different filler substitution ratios on the service performance of asphalt mixtures: Using coal-based synthetic natural gas slag as substitute filler

To investigate the effect of using coal-based synthetic natural gas slag (CNS) as a solid waste-based substitute filler on the service performance of asphalt mixtures, and validate its potential value as a substitute filler in asphalt pavements, thus the CNS powder (CNP) was selected as a solid waste-based substitute filler in this study, and then the variation trends of service performance of asphalt mixtures under different substitution ratios were evaluated by several mechanical tests. Subsequently, the grey relation analysis (GRA) model was conducted to explore the correlation between the different performance indicators and substitution ratios. The results indicate that the incorporation of CNP improved the high temperature performance of the mixture by 25.67–76.93 %, and increased its moisture stability by 15.44–26.99 %. Although the low temperature performance decreased by 0.54–6.19 %, it still met the required standards. Additionally, the incorporation of CNP enhanced the fatigue performance of the mixture by 3.39–7.64 %, while reducing its sensitivity to temperature and strain, and the dynamic modulus master curve constructed by using the Sigmoidal function accurately described the changes in the dynamic viscoelasticity of the mixture. A comparison study revealed that in different mixtures, the high temperature performance indicator consistently exhibited the highest correlation with filler substitution ratio, and this variation pattern was not influenced by filler type and substitution ratio.

Probing the Thermo-oxidative Degradation of Ethylene Vinyl Alcohol (EVOH) by Time-Resolved Rheology and NMR Spectroscopy

EVOH's excellent gas barrier properties have enabled its continued market growth in numerous applications including food packaging, fuel tanks, and construction. However, EVOH's susceptibility to thermo-oxidation limits its ability to be reprocessed. While it is generally known that EVOH degradation leads to cross-linking, detailed degradation rates and mechanisms are not well established. Understanding EVOH degradation has been elusive because readily accessible thermal and spectroscopy methods do not reveal significant changes. Moreover, gel permeation chromatography requires specialized solvents and columns. We report that measuring changes in viscoelasticity with time-resolved rheology (TRR) is a facile way to monitor the temporal dynamics of EVOH degradation. TRR was performed on EVOH grades with ethylene copolymer contents of 27, 32, 48 mol%. As expected, the grade with the highest ethylene content was the most stable. However, with time, all the EVOH grades transitioned from a Carreau-like fluid to a power law fluid and no longer exhibited terminal behavior. Cole-Cole plots also revealed that EVOH relaxation evolved from rapid process into a long, complex process consistent with network formation. The mechanism of degradation was further elucidated by using 13C distortionless enhancement of polarization transfer (DEPT-135) nuclear magnetic resonance spectroscopy. These results showed that degradation occurred by ring-opening of lactone terminal groups that led to cross-linking. This enhanced understanding provides a foundation for developing methods to probe and mitigate EVOH degradation.

Simple and sensitive method for in vitro monitoring of red blood cell viscoelasticity by Quartz Crystal Microbalance with dissipation monitoring (QCM-D)

Viscoelasticity (VE) is the intrinsic mechano-dynamic property enabling red blood cells (RBCs) to undergo prompt and repeated deformations while maintaining structural integrity. Assessing RBC VE and how different stressors can affect it is of great interest. Quartz Crystal Microbalance with Dissipation monitoring (QCM-D) is a technology exploiting high-frequency acoustic waves to probe soft matter rheological properties. In the present study, a QCM-D method is reported for in vitro monitoring of cell VE in viable RBCs. The method is based on casting a sensor-adherent cell monolayer and modeling it as an effective viscoelastic medium, and allows to extrapolate proxy values of both the elastic and the viscous cell shear moduli. Real-time VE changes induced by the known cell VE stressors temperature, medium tonicity, glutaraldehyde, methyl-β-cyclodextrin and cytochalasin D have been reliably identified. The method is relatively simple and inexpensive, non-invasive, and able to seize subtle changes of cell biomechanics. Hence, it could be usefully exploited for in vitro assessment of RBC rheological properties and their alterations induced by external chemico-physical stimuli.

The effect of failure mechanics on the fatigue responses of lumbar intervertebral disc

Lumbar disc herniation is usually caused by the accumulation of long-term mechanical loads and sudden overload damage. Therefore, this study aims to illustrate how fatigue failure in lumbar spine segments is influenced by both cyclic loading magnitude and pre-existing damage. Eighty-six sheep intervertebral disc samples were divided into four groups to test the fatigue responses in healthy and damaged intervertebral discs. Both before and after fatigue loading, the specimens were performed on loading–unloading tests to analyze the viscoelasticity changes, while the specimens were performed on MRI examination to analyze the geometric and morphological changes. The Stress-Failure curve (SN curve) was examined, while the number of cycles to failure of damaged specimens was much smaller than that of healthy specimens at the same stress level during cyclic loading, and the relationship was approximately linear on a logarithmic scale. In addition, the healthy specimens will not accumulate fatigue failure if the compression force remains below 50% of the ultimate compressive tolerance (UTC). Before and after fatigue loading, the loading–unloading curves do not coincide and show obvious strain-rate-dependent viscoelastic characteristics, while the elastic modulus of the damaged specimen is significantly smaller. For magnetic resonance imaging, morphological changes included the changes of nucleus pulposus (NP) shape and area, while fatigue has a more significant effect on ruptured and herniated disc specimens. The dissipated energy of the intervertebral discs under cyclic loading was then calculated based on viscoelastic constitutive equations, which show that the load and preexisting damage both have significant effects on the dissipation rate.

Multi-Zone Visco-Node-Pore Sensing: A Microfluidic Platform for Multi-Frequency Viscoelastic Phenotyping of Single Cells.

This study introduces multi-zone visco-Node-Pore Sensing (mz-visco-NPS), an electronic-based microfluidic platform for single-cell viscoelastic phenotyping. mz-visco-NPS implements a series of sinusoidal-shaped contraction zones that periodically deform a cell at specific strain frequencies, leading to changes in resistance across the zones that correspond to the cell's frequency-dependent elastic G' and viscous G″ moduli. mz-visco-NPS is validated by measuring the viscoelastic changes of MCF-7 cells when their cytoskeleton is disrupted. mz-visco-NPS is also employed to measure the viscoelastic properties of human mammary epithelial cells across the entire continuum of epithelial transformation states, from average- and high-risk primary epithelial cells, to immortal non-malignant (MCF-10A), malignant (MCF-7), and metastatic (MDA-MB-231) cell lines. With a throughput of 600 cells per hour and demonstrated ease-of-use, mz-visco-NPS reveals a remarkable level of single-cell heterogeneity that would otherwise be masked by ensemble averaging.

Deciphering the complex mechanics of atherosclerotic plaques: A hybrid hierarchical theory-microrheology approach

Understanding the viscoelastic properties of atherosclerotic plaques at rupture-prone scales is crucial for assessing their vulnerability. Here, we develop a Hybrid Hierarchical theory-Microrheology (HHM) approach, enabling the analysis of multiscale mechanical variations and distribution changes in regional tissue viscoelasticity within plaques across different spatial scales. We disclose a universal two-stage power-law rheology in plaques, characterized by distinct power-law exponents (αshort and αlong), which serve as mechanical indexes for plaque components and assessing mechanical gradients. We further propose a self-similar hierarchical theory that effectively delineates plaque heterogeneity from the cytoplasm, cell, to tissue levels. Moreover, our proposed multi-layer perceptron model addresses the viscoelastic heterogeneity and gradients within plaques, offering a promising diagnostic strategy for identifying unstable plaques. These findings not only advance our understanding of plaque mechanics but also pave the way for innovative diagnostic approaches in cardiovascular disease management. Statement of significanceOur study pioneers a Hybrid Hierarchical theory-Microrheology (HHM) approach to dissect the intricate viscoelasticity of atherosclerotic plaques, focusing on distinct components including cap fibrosis, lipid pools, and intimal fibrosis. We unveil a universal two-stage power-law rheology capturing mechanical variations across plaque structures. The proposed hierarchical model adeptly captures viscoelasticity changes from cytoplasm, cell to tissue levels. Based on the newly proposed markers, we further develop a machine learning (ML) diagnostic model that sets precise criteria for evaluating plaque components and heterogeneity. This work not only reveals the comprehensive mechanical heterogeneity within plaques but also introduces a mechanical marker-based ML strategy for assessing plaque conditions, offering a significant leap towards understanding and diagnosing atherosclerotic risks.

MXene/polymer dot-decorated flexible sensor for cancer cell-responsive hydrogel with tunable elastic modulus, porosity, and conductivity

This study reports a facile strategy for cancer cell modulated mechanically and electronically tunable hydrogel based on MXene-immobilized hyaluronic acid polymer dot (M-PD). Elevated levels of reactive oxygen species (ROS), such as H2O2 in cancer cells cleave MXene owing to the oxygen-titanium affinity of Ti3C2Tx, altering the physico-mechanical, electrochemical, and fluorescence (FL) properties of the sensor. The H2O2-induced cleavage of M-PD in the hydrogel causes the quenched FL intensity by the Forster resonance energy transfer effect (FRET) to recover, alongside an increase in pore size, influencing shifts in hydrogen bonding and inducing viscoelastic changes in the flexible sensor. This caused physico-mechanical alterations in the sensor, modified the viscosity (G′ decreased by 98.7%), and enhanced the stretchability. Further, in vitro electrochemical impedance spectroscopy (EIS) highlighted the distinct results for cancer cells (B16F10: 8.10 kΩ, MDA-MB-231: 8.30 kΩ), and normal cells (CHO-K1: 3.40 kΩ), showcasing electrochemical differentiation between these cells. Additionally, the flexible M-PD hydrogel sensor exhibits high sensitivity, with detection limits of 2.58 cells/well (CHO-K1), 0.96 cells/well (B16F10), and 1.20 cells/well (MDA-MB-231). Finally, real-time cancer monitoring was achieved by integrating the M-PD hydrogel with a wireless setup on a smartphone.

Research on performance variations of different asphalt binders results from microwave heating during freeze-thaw cycles

Microwave heating (MH) as a sustainable pavement maintenance method can effectively repair the cracks caused by freeze-thaw (FT) damage. However, binders' properties may be weakened during this process then reduces the pavement life. For this purpose, this work aims to investigate the performance changes of neat binders (Nb) and high-viscous binders (Hb) during FT and MH. The physicochemical, rheological, and deformation properties are investigated after FT and MH. Results indicate that asphalt binders become harder and lead to an increase in carbonyl index (CI) and sulfoxide index (SI) after FT. MH has a limited damage level for binders especially for Hb, causing a slight increase in CI and SI, compared to binders after FT. Polymers play an important role in the viscoelastic responses of asphalt binders. Changes in viscoelastic properties of Nb mainly result from the binder damage of FT and MH, while viscoelastic changes of Hb are mainly due to the damage of polymers. This different damage mechanism causes Hb to show better resistance compared to Nb, which is reflected in modulus and phase angle. BBR tests indicate that MH can further deteriorate the damage of both binders, but Hb shows a lower performance decline compared to Nb, and it is recommended to conduct MH at the region with a minimum temperature above −12 °C. MSCR results reveal that FT and MH can improve the rutting resistance of Nb due to the hardening phenomenon after damage, and reduce the elastic stability of Hb due to the damage to polymers. In summary, Nb is sensitive to MH, its performance can be further damaged after MH. Hb has better resistance to MH, its properties do not further deteriorate, so Hb is more applicable to MH.

Use of optical absorption and scattering properties to monitor the change of chemical characteristics, particle structure and viscoelasticity during apple puree processing

This work explored the optical absorption (μa) and reduced scattering (μs') properties at 400–1050 nm (Vis-NIR) and 900–1650 nm (SWIR) of apple puree at different heating times to evaluate their changes in composition and structure. The optical absorption and scattering coefficients of μa and μs' decreased with increasing heating time. The specific μs' coefficients at 432 nm, 455 nm, 1183 nm and 1304 nm were related to particle structural changes. The partial least squares regression (PLSR) models based on μs' coefficients in the combined Vis-NIR and SWIR regions provided satisfactory estimations of puree particle area (Rp2 = 0.90) and particle perimeter (Rp2 = 0.85), whereas the μs' coefficients in the Vis-NIR region predicted puree viscosity (Rp2 = 0.83), elasticity modulus (Rp2 = 0.81) and viscous modulus (Rp2 = 0.78). Consequently, optical properties can be a potential tool to determine structural and rheological changes of apple puree.

Influence of ice properties on wave propagation characteristics in partially frozen soils and rocks: A temperature-dependent rock-physics model

A better understanding of the temperature effects on the propagation characteristics of elastic waves in frozen soils and rocks is imperative for accurately quantifying their freezing degrees. Although the existing rock-physics models based on the three-phase Biot (TPB) theory adeptly interpret observed velocity variation with temperature (VVT) curves, they often lack a comprehensive understanding of the mechanisms underlying attenuation variation with temperature (AVT) curves. In this study, we first extend the TPB theory to incorporate the temperature-dependent properties of ice, such as changes in volumetric fraction, morphology, and viscoelasticity, by integrating the relevant thermodynamic laws. Model parameters related to ice properties and interactions, such as rigidity, shear moduli, density, and friction, are redefined. Then, using a numerical rock-physics modeling approach, we examine influential factors and modes of the wave VVT and AVT responses. Our results indicate that the P- and S-wave velocities increase with source frequency, consolidation degree, and frame-supporting ice content, whereas they decrease with temperature and pore-floating ice content. The P- and S-wave attenuation factors increase with the frame-supporting ice content and decrease with the consolidation degree. Rising temperatures tend to amplify the peak magnitude of the P-wave attenuation factors and shift the central frequency of the S-wave attenuation factors. Finally, within a temperature-controlled laboratory environment, we conduct ultrasonic wave transmission testing on brine-saturated sediment and rock specimens. The results demonstrate that as the temperature increases from −15°C to −3°C, the P- and S-wave velocities decrease, whereas the P-wave attenuation factors decrease and the S-wave attenuation factors initially rise before declining. Our viscoelastic TPB theory outperforms the existing ones in interpreting the S-wave AVT observations. This temperature-dependent rock-physics model holds promise for interpreting the sonic logging data in the time-lapse monitoring of permafrost, glaciers, and Antarctica.

Beyond bone volume: Understanding tissue-level quality in healing of maxillary vs. femoral defects

Currently, principles of tissue engineering and implantology are uniformly applied to all bone sites, disregarding inherent differences in collagen, mineral composition, and healing rates between craniofacial and long bones. These differences could potentially influence bone quality during the healing process. Evaluating bone quality during healing is crucial for understanding local mechanical properties in regeneration and implant osseointegration. However, site-specific changes in bone quality during healing remain poorly understood. In this study, we assessed newly formed bone quality in sub-critical defects in the maxilla and femur, while impairing collagen cross-linking using β-aminopropionitrile (BAPN). Our findings revealed that femoral healing bone exhibited a 73 % increase in bone volume but showed significantly greater viscoelastic and collagen changes compared to surrounding bone, leading to increased deformation during long-term loading and poorer bone quality in early healing. In contrast, the healing maxilla maintained equivalent hardness and viscoelastic constants compared to surrounding bone, with minimal new bone formation and consistent bone quality. However, BAPN-impaired collagen cross-linking induced viscoelastic changes in the healing maxilla, with no further changes observed in the femur. These results challenge the conventional belief that increased bone volume correlates with enhanced tissue-level bone quality, providing crucial insights for tissue engineering and site-specific implant strategies. The observed differences in bone quality between sites underscore the need for a nuanced approach in assessing the success of regeneration and implant designs and emphasize the importance of exploring site-specific tissue engineering interventions. Statement of significanceAccurate measurement of bone quality is crucial for tissue engineering and implant therapies. Bone quality varies between craniofacial and long bones, yet it's often overlooked in the healing process. Our study is the first to comprehensively analyze bone quality during healing in both the maxilla and femur. Surprisingly, despite significant volume increase, femur healing bone had poorer quality compared to the surrounding bone. Conversely, maxilla healing bone maintained consistent quality despite minimal bone formation. Impaired collagen diminished maxillary healing bone quality, but had no further effect on femur bone quality. These findings challenge the notion that more bone volume equals better quality, offering insights for improving tissue engineering and implant strategies for different bone sites.

Brillouin Biosensing of Viscoelasticity across Phase Transitions in Ovine Cornea.

Noninvasive in situ monitoring of viscoelastic characteristics of corneal tissue at elevated temperatures is pivotal for mechanical property-informed refractive surgery techniques, including thermokeratoplasty and photorefractive keratectomy, requiring precise thermal modifications of the corneal structure during these surgical procedures. This study harnesses Brillouin light scattering spectroscopy as a biosensing platform to noninvasively probe the viscoelastic properties of ovine corneas across a temperature range of 25-64 °C. By submerging the tissue samples in silicone oil, consistent hydration and immiscibility are maintained, allowing for their accurate sensing of temperature-dependent mechanical behaviors. We identify significant phase transitions in the corneal tissue, particularly beyond 40 °C, likely due to collagen unfolding, marking the beginning of thermal destabilization. A subsequent transition, observed beyond 60 °C, correlates with collagen denaturation. These phase transformations highlight the cornea's sensitivity to both physiologically reversible and irreversible viscoelastic changes induced by mild to high temperatures. Our findings underscore the potential of the Brillouin biosensing technique for real-time diagnostics of corneal biomechanics during refractive surgeries to attain optimized therapeutic outcomes.

Importance of Fluid/Fluid Interactions in Enhancing Oil Recovery by Optimizing Low-Salinity Waterflooding in Sandstones

Low-salinity waterflooding/smart waterflooding (LSWF/SWF) is a technique involving the injection of water with a modified composition to alter the equilibrium between rock and fluids within porous media to enhance oil recovery. This approach offers significant advantages, including environmental friendliness and economic efficiency. Rock/fluid mechanisms such as wettability alteration and fines migration and fluid/fluid mechanisms such as a change in interfacial tension and viscoelasticity are considered active mechanisms during LSWF/SWF. In this study, we evaluated the effect of these mechanisms, by LSWF/SWF, on sandstones. To investigate the dominant mechanisms, coreflooding studies were performed using different injected fluid composition/salinity and wettability states. A comparative analysis of the recovery and mobility reduction factor was performed to clarify the conditions at which fluid/fluid mechanisms are also effective. Our studies showed that wettability alteration is the most dominant mechanism during LSWF/SWF, but, for weak oil-wet cases, optimizing brine compositions may activate fluid/fluid mechanisms. Brine composition significantly influences interface stability and performance, with sulfate content playing a crucial role in enhancing interface properties. This was observed via mobility behavior. A comparative analysis of pressure differentials showed that fines migration may act as a secondary mechanism and not a dominant one. This study highlights the importance of tailored brine compositions in maximizing oil recovery and emphasizes the complex interplay between rock and fluid properties in enhanced oil recovery strategies.

Early elastic and viscoelastic corneal biomechanical changes after photorefractive keratectomy and small incision lenticule extraction.

To compare early changes in the corneal biomechanical parameters after photorefractive keratectomy (PRK) and small incision lenticule extraction (SMILE) and their correlations with corneal shape parameters. One hundred twenty four eyes received myopic PRK and SMILE for similar amounts of myopia. Corneal tomography with Pentacam HR, biomechanical parameters using Corvis ST, and Ocular Response Analyzer (ORA) were evaluated before and 2weeks after surgery. The change in each parameter was compared between groups, while the difference in central corneal thickness and cornea-compensated intraocular pressure measured before and after surgery were considered as covariates. A significant reduction was seen in the corneal stiffness parameter at first applanation, and an increase in deformation amplitude ratio (DAR), and integrated inverse radius (IIR) in both groups after surgery (p < 0.001) Changes in DAR, and IIR were significantly greater in the SMILE than in the PRK group (p < 0.001) Corneal hysteresis (CH) and corneal resistance factor(CRF) decreased in both SMILE and PRK groups after surgery, (p < 0.001) with no statistically significant difference between groups (p > 0.05) Among new Corvis ST parameters, DAR showed a significant correlation with changes in Ambrosio relational thickness in both groups (p < 0.05). Both techniques caused significant changes in corneal biomechanics in the early postoperative period, with greater elastic changes in the SMILE group compared to the PRK group, likely due to lower tension in the SMILE cap and thinner residual stromal bed in SMILE. There were no differences in viscoelastic changes between them, so the lower CH may reflect the volume of tissue removed.

Shp2 contributes to the regulation of nuclear shape and cellular viscoelasticity in response to substrate spatial cues

Cell polarization can be guided by substrate topology through space constraints and adhesion induction, which are part of cellular mechanosensing pathways. Here, we demonstrated that protein tyrosine phosphatase Shp2 plays a crucial role in mediating the response of cells to substrate spatial cues. When compared to cells spreading on surfaces coated uniformly with fibronectin (FN), cells attached to 10 μm-width FN-strip micropattern (MP), which provides spatial cues for uniaxial spreading, exhibited elongated focal adhesions (FAs) and aligned stress fibers in the direction of the MP. As a result of uniaxial cell spreading, nuclei became elongated, dependent on ROCK-mediated actomyosin contractility. Additionally, intracellular viscoelasticity also increased. Shp2-deficient cells did not display elongated FAs mediated by MP, well-aligned stress fibers, or changes in nuclear shape and intracellular viscoelasticity. Overall, our data suggest that Shp2 is involved in regulating FAs and the actin cytoskeleton to modulate nuclear shape and intracellular physical properties in response to substrate spatial cues.

Constraining Parameter Uncertainties in the Coulomb Rate–State Approach: A Case Study of Seismicity in the Longmenshan Region after the 2008 Mw 7.9 Wenchuan Earthquake, China

Abstract The rate–state frictional law, coupled with the Coulomb failure stress changes (ΔCFS), is one of the most popular physics-based models to forecast seismicity rate changes following a major earthquake. However, its effectiveness is hampered by parameter uncertainties. To seek possible solutions for such uncertainties, this article carried out retrospective forecasts of the decade-long seismicity in the Longmenshan region, China, after the 2008 Mw 7.9 Wenchuan earthquake, and proposed methods to constrain parameter uncertainties. First, we derived spatially variable ta and Aσ from fault-slip rates. This method not only provides observational constraints for these two parameters but also reflects spatial variations of fault rate–state properties. Second, although both complete and declustered background catalogs are common in Coulomb rate–state forecasts, this study demonstrated that declustering avoids false alerts of seismicity rate increase that resulted from temporary seismicity fluctuations in the background catalog. Finally, we extended the model from its typical application based on a stress step (the coseismic stress change) to a calculation that allows a more complex stress evolution (the postseismic viscoelastic stress change). With these methods to constrain parameter uncertainties, we are able to obtain more reliable forecasts.

Promote or inhibit turbulence drag reduction behavior of surfactant solutions with different micelle structures by certain nanoparticle addition

The micelle structure of surfactant is easy to be destroyed in the flow process resulting in a decrease in its drag reduction (DR) efficiency; therefore, how to strengthen the stability of the micelle structure during the flow process and thus improve the drag reduction efficiency deserves intensive research. In this work, by comparing a variety of nanoparticles, hydrophobic silica nanoparticles were selected as the best additive to enhance the turbulence drag reduction efficiency of surfactant solution with spherical micelle structure. The experimental results also demonstrated that the hydrophobic silica nanoparticles had a reinforcing effect on anionic, cationic, nonionic, and zwitterionic surfactant solutions with the same concentration (dominated by spherical micelles), and the optimal nanoparticle addition concentration and maximum drag reduction rate were obtained. Meanwhile, the effect of silica nanoparticles on the turbulence drag reduction efficiency of surfactant solutions with different micelle structures was evaluated by inducing the surfactant micelle structure change. It was shown that the hydrophobic silica nanoparticles had a strengthening effect on the turbulence drag reduction performance of surfactant solutions with spherical micelle structure, while they had an inhibiting effect on the turbulence drag reduction performance of surfactant solutions with worm-like micelle structure. The change in solution viscoelasticity indicated that the decrease in viscoelasticity was the main reason for the decrease in drag reduction efficiency of surfactant solution with worm-like micelle structure when silica nanoparticles were added. A mechanism for the interaction of hydrophilic/hydrophobic silica nanoparticles with spherical micelles and wormlike micelle structures was finally discussed and proposed.

Low-/Negative-Pressure Hydrocephalus: To Understand the Formation Mechanism from the Perspective of Clinicians.

Low-/negative-pressure hydrocephalus (LPH/NePH) is uncommon in clinical practice, and doctors are unfamiliar with it. LPH/NePH is frequently caused by other central nervous system diseases, and patients are frequently misdiagnosed with other types of hydrocephalus, resulting in delayed treatment. LPH/NePH therapy evolved to therapeutic measures based on "external ventricular drainage below atmospheric pressure" as the number of patients with LPH/NePH described in the literature has increased. However, the mechanism of LPH/NePH formation is unknown. Thus, understanding the process of LPH/NePH development is the most important step in improving diagnosis and treatment capability. Based on case reports of LPH/NePH, we reviewed theories of transcortical pressure difference, excessive cerebral venous drainage, brain viscoelastic changes, and porous elastic sponges.

Evaluation of Moisture-Induced Stresses in Wood Cross-Sections Determined with a Time-Dependent, Plastic Material Model during Long-Time Exposure

In recent years, the use of timber as a building material in larger construction applications such as multi-story buildings and bridges has increased. This requires a better understanding of the material to realize such constructions and design them more economically. However, accurate computational simulations of timber structures are challenging due to the complexity and inhomogeneity of this naturally grown material. It exhibits growth inhomogeneities such as knots and fiber deviations, orthotropic material behavior and moisture dependence of almost all physical parameters. Describing the creep response of wood under real climate conditions is particularly difficult. Changes in moisture content, plasticity and viscoelasticity affect moisture-induced stresses and potentially lead to cracks and structural damage. In this paper, we apply a material model that combines time and moisture-dependent behavior with multisurface plasticity to simulate cross-sections of different dimensions over a 14-month climate period. Our findings indicate that considering this long-term behavior has a minor impact on moisture-induced stresses during the drying period. However, during the wetting period, neglecting the time- and moisture-dependent material behavior of wood leads to a significant overestimation of tensile stresses within the cross-section, resulting in unrealistic predictions of wetting-induced fracture. Therefore, simulations during wetting periods require a sophisticated rheological model to properly reproduce the stress field.

A Novel Experimental Approach for the Measurement of Vibration-Induced Changes in the Rheological Properties of Ex Vivo Ovine Brain Tissue.

Increased incidence of traumatic brain injury (TBI) imposes a growing need to understand the pathology of brain trauma. A correlation between the incidence of multiple brain traumas and rates of behavioural and cognitive deficiencies has been identified amongst people that experienced multiple TBI events. Mechanically, repetitive TBIs may affect brain tissue in a similar way to cyclic loading. Hence, the potential susceptibility of brain tissue to mechanical fatigue is of interest. Although temporal changes in ovine brain tissue viscoelasticity and biological fatigue of other tissues such as tendons and arteries have been investigated, no methodology currently exists to cyclically load ex vivo brain tissue. A novel rheology-based approach found a consistent, initial stiffening response of the brain tissue before a notable softening when subjected to a subsequential cyclic rotational shear. History dependence of the mechanical properties of brain tissue indicates susceptibility to mechanical fatigue. Results from this investigation increase understanding of the fatigue properties of brain tissue and could be used to strengthen therapy and prevention of TBI, or computational models of repetitive head injuries.