Visceral Protein Research Articles

Exploring Systemic Comorbidities and Lifestyle Factors Associated With Seborrheic Dermatitis: A Scoping Review.

Seborrheic dermatitis (SD), a chronic inflammatory skin condition consisting of itchy, red patches with greasy scales, has been linked to numerous systemic conditions. This review evaluates comorbidities and lifestyle factors that are associated with seborrheic dermatitis. A literary search was conducted in August 2024 using EMBASE, PubMed, and Medline Industries, and evaluated according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The following results were found from this search. Diet may play a role in seborrheic dermatitis as participants with a diet high in simple carbohydrates, high in vitamin D, and low in iron have a higher instance of disease. Femoral cartilage thickness (FCT), a potential indicator of early osteoarthritis, was greater in patients with SD than in controls and was positively correlated with increasing SD severity. SD has also been associated with chronic diseases. Nearly half of Parkinson's disease (PD) patients in one study also had SD. As the severity of Parkinson's disease symptoms increases, the development of SD was observed to occur at a much higher rate, with the burden of SD positively correlated to the severity of PD symptoms. In one cross-sectional study of patients with SD, the most common systemic comorbidities were hypertension and diabetes, however, this finding was not statistically significant. Another study found that obesity was common amongst patients with SD, but this finding was also not significant. Visceral protein levels and height, however, were positively associated with increased SD disease severity. Metabolic syndrome and lower high-density lipoprotein (HDL) and triglycerides have been shown to be associated with more severe SD. Osteoporosis had a higher prevalence and faster disease progression in individuals with comorbid SD than in controls. Around 16% of individuals with psychiatric disorders, such as schizophrenia, bipolar disorder, and major depressive disorder, were found to have SD. HIV is a disease with higher incidence of SD, although the prevalence of comorbid SD may be decreasing as the use of antiretroviral therapy increases. These associations highlight the complex nature of seborrheic dermatitis and underscore the necessity for further research to better understand these relationships and improve disease management.

The Sex Dependent and Independent Effects of Dietary Whey Proteins Are Passed from the Mother to the Offspring.

The study assesses the metabolic impact of dietary whey proteins across generations. Virgin females are fed 20% energy whey proteins with 70% energy carbohydrates, which reduces body weight gain and visceral adipose compared to controls fed dietary casein. In contrast, the males are unresponsive. The effect is accentuated in reproductive females that also have reduced plasma levels of glucose. The responsive females have increased cecal levels of pyruvic and lactic acid, suggesting a greater catabolism of carbohydrates in the gut. While the male and female offspring born to mothers on whey proteins continue to reduce body weight gain, the female offspring further decreases the visceral and subcutaneous tissues and increases the gut capacity to breakdown dietary carbohydrates and proteins, whereas the male offspring are able to only decrease the visceral and increase protein catabolism in the gut. The ileum of male mice responded by reducing the gene expression for fibroblast growth factor 15 and increasing the expression of chymotrypsinogen B1. The effect of whey proteins on growth can be passed from the mother to the offspring without a sex preference, whereas the transmission of gut activity and adiposity are dependent on the sex of the offspring.

Prognostic value of visceral protein ratios in patients with colon cancer

This study aimed to assess different combinations of visceral proteins and to elucidate their value in predicting progression-free survival (PFS) and overall survival (OS) in patients with colon cancer. The visceral protein ratios included the albumin-globulin ratio (AGR), prealbumin-globulin ratio (PGR), and albumin-prealbumin-globulin ratio (APGR). Compared with AGR and PGR, APGR had the best time-dependent area under the receiver operating characteristic curves for predicting the outcomes. High AGR/PGR/APGR levels were associated with an increased risk of mortality. High AGR (HR = 0.816, 95%CI: 0.719–0.925, p = 0.001), PGR (HR = 0.831, 95%CI: 0.724–0.953, p = 0.008), and APGR (HR = 0.789, 95%CI: 0.688–0.904, p < 0.001) were independent risk factors for PFS. For every SD increase in AGR, PGR, and APGR, the risk of poor OS in patients with colon cancer was reduced by 16.9 % (HR = 0.831, 95%CI, 0.733–0.943; p = 0.001), 15.1 % (HR = 0.849, 95%CI, 0.739–0.976; p = 0.021), and 19.1 % (HR = 0.809, 95%CI, 0.705–0.928; p = 0.002), respectively. Logistic regression models showed that AGR, PGR, and APGR were independent factors that affected recurrence. Visceral protein ratios are independent predictors of PFS and OS. Compared to the existing visceral protein ratios (AGR and PGR), APGR is a more accurate and sensitive indicator for predicting the outcomes of patients with colon cancer.

Virtual-screening of xanthine oxidase inhibitory peptides: Inhibition mechanisms and prediction of activity using machine-learning

Xanthine oxidase (XO) inhibitory peptides can prevent XO-mediated hyperuricemia. Currently, QSAR about XO inhibitory peptides with different lengths remains to be enriched. Here, XO inhibitory peptides were obtained from porcine visceral proteins through virtual-screening. A prediction model was established by machine-learning. Virtual-screening retained four lengths of peptides, including 3–6. Molecular-docking recognized their binding sites with XO and showed residues W, F, and G were the key amino acids. Datasets of XO inhibitory peptides therewith were established. The optimal model was used to generalize the peptides reported. Results showed that the R2 of the tripeptide, tetrapeptide, pentapeptide and hexapeptide in the generalisation test were R2 = 0.81, R2 = 0.82, R2 = 0.83 and R2 = 0.83, respectively. Overall, this work can serve as a reference for explaining the activity mechanism of XO inhibitory peptides and predicting the activity of XO inhibitory peptides.

521 Assessing the Utility of Visceral Proteins as Markers of Nutrition

521 Assessing the Utility of Visceral Proteins as Markers of Nutrition

Poor diet quality is associated with biochemical parameters of protein nutritional status after Roux-en-Y gastric bypass

ObjectiveTo assess diet quality and its association with body and biochemical parameters in patients who underwent Roux-en-Y gastric bypass (RYGB). MethodsProspective observational study with individuals of both sexes subjected to RYGB. Body composition, biochemical parameters, and diet quality were assessed before and six months after RYGB. Diet quality was assessed by the Healthy Eating Index (HEI). Data were analyzed by the paired t-test or Wilcoxon signed-rank test, with a significance level of 5%. Spearman's correlation and simple linear regression were performed between variables. ResultsThe final sample included 34 patients. Their diet was classified as poor before and 6 mo after RYGB. BMI, fat mass, fat-free mass, waist perimeter, serum total protein, transthyretin, alpha-1-acid glycoprotein, and C-reactive protein decreased significantly (P < 0.05). Variations in the HEI score and caloric intake were associated with serum albumin and transthyretin (P < 0.05). ConclusionPoor diet quality was present before and six months after RYGB, and the study data suggest that poor diet quality is associated to a risk of loss of lean body mass and visceral protein six months after RYGB.

Dynamics of main markers of protein metabolism and microelements in patients with new coronavirus infection

Objective. To study the dynamics of the main markers of protein metabolism and microelements in patients with a new coronavirus infection. Materials and methods. A prospective clinical and laboratory study of the dynamics of the main markers of protein metabolism and microelements was carried out in 62 patients with a new coronavirus infection complicated by the development of pneumonia with a moderate course on the basis of Perm regional clinical hospital of infectious diseases in 2021–2022. On the 1st and 14th days of hospitalization all patients underwent general clinical and biochemical studies. The concentrations of total protein, albumin, transferrin, Fe, Zn and Cu was also determined. Statistic processing of the results was carried out using Microsoft Excel 2000 and “Statistica 10”. Results. A decrease in visceral pool proteins was revealed. It indicated their active consumption and formation of hypermetabolism - hypercatabolism syndrome in a moderate course of the infection. A progressive deficiency of Fe and Zn, correlating with life-threatening complications and deaths was revealed. Conclusions. The course of a new coronavirus infection contributes to the development of metabolic disorders, and the identified deficiency of macro- and microelements is a predictor of a severe course of the infection.

Что мы знаем о пищевом статусе пациента с первичным билиарным холангитом?

The purpose of the article is to summarize modern ideas about the importance of nutritional status of patients with primary biliary cholangitis (PBC) and to draw attention to need of assessment and correction of malnutrition in this patient category. Nutritional disorder of patients with PBC affects prognosis and quality of life. Already at an early stage, the development of energy deficiency, activation of compensatory mechanisms for obtaining energy from fatty acids and amino acids of the somatic pool of proteins with progressive loss of body weight are observed. Violation of bile secretion processes leads to the development of maldigestion and malabsorption, vitamin and mineral deficiency. In turn, insufficient intake of vitamins and minerals causes hypovitaminosis, disturbances in the metabolism of microelements, in particular calcium, the development of osteopenia and osteoporosis. The progressive development of liver failure reduces the protein-synthetic function of the liver, leading to a deficiency of the visceral protein pool and progressive protein deficiency and sarcopenia. Thus, nutritional disorder directly affects the course of disease, response to therapy and prognosis of the disease, which determines the need of assessment and correction of nutritional status during the observation and treatment of patients with PBC.

A revised model of energy transactions and body composition in sheep.

A mechanistic, dynamic model was developed to calculate body composition in growing lambs by calculating heat production (HP) internally from energy transactions within the body. The model has a fat pool (f) and three protein pools: visceral (v), nonvisceral (m), and wool (w). Heat production is calculated as the sum of fasting heat production, heat of product formation (HrE), and heat associated with feeding (HAF). Fasting heat production is represented as a function of visceral and nonvisceral protein mass. Heat associated with feeding (HAF) is calculated as ((1 - km) x MEI), where km is partial efficiency of ME use for maintenance, and MEI = metabolizable energy intake) applies at all levels above and below maintenance. The value of km derived from data where lambs were fed above maintenance was 0.7. Protein change (dp/dt) is the sum of change in the m, v, and w pools, and change in fat is equal to net energy available for gain minus dp/dt. Heat associated with a change in body composition (HrE) is calculated from the change in protein and fat with estimated partial efficiencies of energy use of 0.4 and 0.7 for protein and fat, respectively. The model allows for individuals to gain protein while losing fat or vice versa. When evaluated with independent data, the model performed better than the current Australian feeding standards (Freer etal., 2007) for predicting protein gain in the empty body but did not perform as well as for gain of fat and fleece-free empty body weight. Models performed similarly for predicting clean wool growth. By explicit representation of the major energy using processes in the body, and through simplification of the way body composition is computed in growing animals, the model is more transparent than current feeding systems while achieving similar performance. An advantage of this approach is that the model has the potential for wider applicability across different growth trajectories and can explicitly account for the effects of systematic changes on energy transactions, such as the effects of selective breeding, growth manipulation, or environmental changes.

Collecting health-related research data using consumer-based wireless smart scales

BackgroundSerious public-health concerns such as overweight and obesity are in many cases caused by excess intake of food combined with decreases in physical activity. Smart scales with wireless data transfer can, together with smart watches and trackers, observe changes in the population’s health. They can present us with a picture of our metabolism, body health, and disease risks. Combining body composition data with physical activity measurements from devices such as smart watches could contribute to building a human digital twin. ObjectiveThe objectives of this study were to (1) investigate the evolution of smart scales in the last decade, (2) map status and supported sensors of smart scales, (3) get an overview of how smart scales have been used in research, and (4) identify smart scales for current and future research. MethodWe searched for devices through web shops and smart scale tests/reviews, extracting data from the manufacturer’s official website, user manuals when available, and data from web shops. We also searched scientific literature databases for smart scale usage in scientific papers. ResultWe identified 165 smart scales with a wireless connection from 72 different manufacturers, released between 2009 and end of 2021. Of these devices, 49 (28%) had been discontinued by end of 2021. We found that the use of major variables such as fat and muscle mass have been as good as constant over the years, and that minor variables such as visceral fat and protein mass have increased since 2015. The main contribution is a representative overview of consumer grade smart scales between 2009 and 2021. ConclusionThe last six years have seen a distinct increase of these devices in the marketplace, measuring body composition with bone mass, muscle mass, fat mass, and water mass, in addition to weight. Still, the number of research projects featuring connected smart scales are few. One reason could be the lack of professionally accurate measurements, though trend analysis might be a more feasible usage scenario.

Nutritional Support for Alcoholic Liver Disease.

Malnutrition is a common finding in alcohol use disorders and is associated with the prognosis of patients with alcoholic liver disease (ALD). These patients also frequently show deficiencies in vitamins and trace elements, increasing the likelihood of anemia and altered cognitive status. The etiology of malnutrition in ALD patients is multifactorial and complex and includes inadequate dietary intake, abnormal absorption and digestion, increased skeletal and visceral protein catabolism, and abnormal interactions between ethanol and lipid metabolism. Most nutritional measures derive from general chronic liver disease recommendations. Recently, many patients with ALD have been diagnosed with metabolic syndrome, which requires individualized treatment via nutritional therapy to avoid overnutrition. As ALD progresses to cirrhosis, it is frequently complicated by protein-energy malnutrition and sarcopenia. Nutritional therapy is also important in the management of ascites and hepatic encephalopathy as liver failure progresses. The purpose of the review is to summarize important nutritional therapies for the treatment of ALD.

Energy Metabolism and Protein Balance in Growing Rats Housed in 18°C or 28°C Environments and Fed Different Levels of Dietary Protein

A study was performed to investigate the effect of environmental temperature and increasing levels of protein in the diet on visceral organ size, digestibility, protein balance and energy metabolism in rats. Thirty-six male Wistar rats, initial body weight 77–80 g, were used in a factorial design consisting of three levels of dietary protein and two environmental temperatures of either 18 or 28°C. Three fish meal-based diets were prepared to contain 91, 171 and 262 g protein (N × 6.25/kg diet). Gas-exchange measurements were made and urine and feces were quantitatively collected. The weights of the visceral organs from rats housed at 18°C were greater (P < 0.05) than those of rats housed at 28°C. The digestibilities of dry matter and protein were not affected by environmental temperature, whereas fat and energy digestibilities were higher (P < 0.05) at 18°C than at 28°C. As the level of protein was increased, the digestibilities of protein, energy and fat increased (P < 0.05). Protein intake and protein retention were higher at 18°C (P < 0.05) than at 28°C and increased (P < 0.05) as dietary protein concentration increased. Apparent biological value was lower (P < 0.05) at 18°C than at 28°C and decreased (P < 0.05) as dietary protein level increased. Heat production as a percentage of metabolizable energy was higher (P < 0.05) for the low protein diet than for the medium and high protein diets. The efficiency of energy utilization was depressed (P < 0.05) for the high protein diet when rats were kept at 28°C. The results suggest that thermogenesis was induced when low protein was fed. The increase in thermogenesis may have been important in regulating energy balance and maintaining a constant body temperature in a cold environment.

HUBUNGAN KADAR ALBUMIN DAN INDEKS MASSA TUBUH PADA PASIEN HEMODIALISIS RUTIN DI RSUD ULIN BANJARMASIN

Malnutrition is most common risk in patients undergoing routine hemodialysis compared to other general popolation, malnutrition is a condition in which the body leses muscle and visceral protein reserves. Albumin levels and body mass index in routine hemodialysis patient, in this studi using a cross sectional study with Pearson product momment correlation test. This study used secondary data on routine hemodialysis patients and clinical pathology laboratory at Ulin Hospital Banjarmasin. The research method using random sampling, obtained as many 74 subjects with subject distribution of 92 peeople. The results of study obtained correlation value of albumin levels and body mass index with a value of p =0.7 and a value of r = -0.030

NRS‑2002 scale impact on nutritional status screening of patients with acute cerebrovascular accident

Evaluation of the nutritional status at an early stage of hospitalization in patients with acute cerebrovascular insufficiency (CVA) is important for providing timely nutritional support. According to the Russian clinical guidelines for nutritional support of patients with stroke, the NRS‑2002 scale is essential to assessment the nutritional status. However, due to the obesity, about 30 % of patients do not entered into the general category of patients with CVA to get the standard examination.Aim. To analyze the NRS‑2002 scale effectiveness in patients with acute cerebrovascular accident, taking into account the somatic and visceral protein pools.Materials and methods. In the case of the prospective study the 140 patients with CVA were hospitalized in the primary vascular department of the City Clinical Hospital n. a. V. V. Vinogradov (Moscow, Russia), and were screened by the simplified malnutrition scoring system and the NRS‑2002 scale.Results. The research reveals: A low risk of malnutrition in 34,3 % of all cases and 72,7 % in patients under 70 years; the high BMI – Me‑26,6 (24,2–30,8) kg/m²; the protein deficiency in 140 (25.7 %) of patients with normal somatic protein pool and in 66 (28.8 %) of patients under 70 years.Conclusions. Detecting the risk of malnutrition with the NRS‑2002 scale in the early stage after hospitalization is not always informative due to the overweight and the age less than 70 years. The visceral protein pool analysis should be performed in all patients, independently of the NRS‑2002 scale and the somatic protein pool results.

Effect of a personalized nutritional intervention program on nutritional status, quality of life and mortality in hemodialysis patients.

dietary advice provided through a nutritional intervention program (NIP) is recommended by renal clinic guidelines to prevent or treat malnutrition, that could improve quality of life (QoL) and survival in hemodialysis (HD) patients. This study set out to evaluate the effect of a personalized NIP on the nutritional status and its impact on QoL and mortality in dialyzed patients. this was a 12-month intervention study with regular follow-up in which nutritional parameters were measured at baseline and after 6 and 12 months. QoL was assessed by the Kidney Disease Quality of Life version 1.2 (KDQOL-SF) at baseline and at the end of the study. All dialyzed patients received individualized consultations with a trained dietitian. The content of the nutritional education program included a personalized meal plan and educational materials addressing nutrition to manage fluids, electrolytes, and vitamin D. a total of 75 patients were included. After the NIP, visceral proteins, phosphorous, potassium and vitamin D levels had improved significantly (p < 0.001). The percentage of well-nourished patients increased by 30 % (p < 0.001). At the end of the study, the well-nourished patients had significantly improved scores on the general summary areas of the KDQOL-SF, reduced worry concerning fluid and dietary restrictions (p < 0.001), and the survival rate was 12 months longer (p < 0.01). the results of this study suggest that personalized NIP contributed to improved nutritional status, QoL and survival in HD patients.

Pre-procedural serum albumin concentration is associated with length of stay, discharge destination, and 90-day mortality in patients after transcatheter aortic valve replacement.

As visceral protein expression may influence outcomes in patients with cardiovascular disease, we investigated whether pre-procedural albumin concentration is associated with length of stay (LOS) and 90-day mortality after transcatheter aortic valve repair (TAVR). We retrospectively analyzed data from TAVR patients at our institution between January 2013 and December 2017. For all patients, baseline albumin concentration was assessed between one and four weeks before the procedure. To investigate the association between albumin concentration and outcomes, we performed regression analyses, controlling for Society of Thoracic Surgeons, New York Heart Association classification, and Kansas City Cardiomyopathy Questionnaire 12 scores. Three hundred eighty patients were included in the analyses. Cox-proportional hazards regression showed that patients with albumin concentrations <3.5 g/dL were 80% more likely to have prolonged ICU LOS (HR 1.79; 95%CI 1.04-2.57, P = 0.03) and 70% more likely to have prolonged hospital LOS (HR 1.68; 95%CI 1.01-2.46, P = 0.04) compared to patients with albumin concentrations >3.5 g/dL. Logistic regression showed that patients with albumin concentrations <3.5 g/dL were four times more likely to not survive to 90 days (OR 3.94; 1.13-12.63, P = 0.03) after their TAVR compared to patients with albumin concentrations >3.5 g/dL. Our data suggest that patients with pre-procedural albumin concentrations <3.5 g/dL are at an increased risk of adverse outcomes after TAVR compared to patients with albumin concentrations ≥3.5 g/dL. Prospective studies are needed to determine whether risk stratification based on pre-procedural albumin can improve outcomes and whether targeted interventions can improve pre-procedural albumin concentrations in potential TAVR candidates.

Нутрітивний статус у хворих з раком порожнини рота та ротоглотки в предопераційному періоді

Head and neck tumors are a significant group of malignant neoplasms. Dysphagia is one of the most important problems in the nutrition of patients with tumors of the oral cavity and oropharynx. It is present in almost every patient and accounts for 90-95% of cases, both in the preoperative and postoperative period. Problems with swallowing in head and neck cancer may be related, first of all, to the type and size of the tumor itself, which disrupts the ability to eat. Disturbance in the pushing of the food lump develops as a result of dysfunction of the affected muscles or damage to peripheral nerves. There are also early and late disturbances of normal swallowing after radiation and chemotherapy for malignant tumors of the oral cavity, oropharynx, and larynx. Such patients already have a nutritional deficiency in the preoperative period. The purpose of the study was to assess the frequency of nutritional insufficiency in patients with oncology of the oral cavity and oropharynx in the preoperative period and to identify the most significant criteria for nutritional status violations. Materials and methods. The study was conducted in 41 patients, aged 38-55 years (35 men, 6 women) with stage I-III of malignant tumors of the lips, tongue, floor of the mouth and oropharynx. We determined the dynamics of weight in cancer patients with pathology of the oral cavity and oropharynx from the onset of the disease and at the stages of treatment. The patient was weighed at the time of hospitalization and in the postoperative period for 3, 5, 7, 9, 12 days. Anamnestically, weight was determined 3-6 months after the first signs of the disease. Body mass index, shoulder circumference and thickness of the skin-fatty fold of the triceps were measured and calculated, as well as laboratory indicators – biochemical markers: total protein, albumin, transferrin, absolute number of lymphocytes. Results and discussion. The patient's weight loss before the first signs of the disease averaged 6-8 kg. In the postoperative period, a gradual weight loss was noted until the ninth day after the operation, and then weight stabilization was observed. In nine days, patients lost 4-7 kg of weight from the time of hospitalization. The fastest weight loss was observed in the period of 3-7 days of the postoperative period. The average values of anthropometric indicators in the studied group, with the exception of a moderate decrease in the size of the skin-fatty fold in men, were within the normal range. A decrease in the absolute number of lymphocytes, less than 1.5 thousand in 1 μl (p &lt;0.05), was noted in 71% (29/41). Indicators characterizing the visceral protein pool (total protein, transferrin) were also within normal values, except for albumin, which was slightly reduced in 63%. Conclusion. A comprehensive study revealed in the preoperative period in patients with oncopathology of the oral cavity and oropharynx a high incidence of malnutrition (85%). The main contribution to the change of trophological status is a decrease in the cellular component of immunity and albumin

Angiotensin(1–7) attenuates visceral adipose tissue expansion and lipogenesis by suppression of endoplasmic reticulum stress via Mas receptor

BackgroundWhite adipose tissue can be classified based on its location as subcutaneous and visceral fat, and the latter accumulation is reported to be more detrimental to metabolism. Endoplasmic reticulum (ER) stress has been demonstrated to regulate lipogenesis. The peptide angiotensin(1–7) [Ang(1–7)], which can be produced from angiotensin II (AngII) by angiotensin-converting enzyme 2 (ACE2), plays its role through Mas receptor, also participates in the regulation of lipid metabolism in adipose tissue, however, whether ER stress is involved in the mechanism remains unclear. Therefore, we aimed to explore the role of Ang(1–7) pathway in regulating visceral adipose tissue expansion and ER stress.MethodsACE2 knockout (KO), Mas KO and C57BL/6 J mice were fed with high fat diet. Db/db mice were treated with either normal saline, Ang(1–7) or Ang(1–7) combined with Mas receptor inhibitor A779 using mini osmotic pumps. Fat mass was weighted, fat distribution was evaluated by MRI, and lipid profile and adipokines in epididymal adipose tissue were measured by ELISA kits, and histology of epididymal adipose tissue was also analyzed in multiple animal models. Additionally, differentiated 3T3-L1 cells were pre-loaded with palmitic acid to induce ER stress, then treated with drugs as those administrated to db/db mice. ER stress and lipogenesis related proteins in mice adipose and differentiated 3T3L-1 cells were analyzed by Western blot.ResultsACE2 or Mas KO mice exhibited increased visceral adipose tissue, adipocyte size and protein expression of lipogenesis and ER stress related markers in epididymal adipose tissue compared to wild-type mice. Db/db mice treated with Ang(1–7) displayed decreased visceral fat mass, adipocyte size and protein expression of lipogenesis and ER stress markers in epididymal adipose tissue compared to those treated with normal saline, while A779 partly attenuated these effects. Additionally, Ang(1–7) improved ER stress and lipogenesis markers in differentiated 3T3-L1 cells pre-loaded with palmitic acid.ConclusionsOur findings indicated that Ang(1–7) attenuated visceral adipose tissue expansion and lipogenesis by suppression of ER stress via Mas receptor. The present study provides a potential perspective for Ang(1–7) for the therapeutics of obesity and related disorders.

Decrease phase angle one year after Roux-en-Y bypass and sleeve gastrectomy is related to risks to protein nutritional status.

Phase angle (PhA) has been used as an indicator of nutritional status. However, the significance of PhA reduction after bariatric surgery is less known. This study evaluated PhA and its relation with biochemical parameters and prognostic inflammatory and nutritional indices at a one-year follow-up of patients subjected to Roux-en-Y bypass (RYGB) or sleeve gastrectomy (SG). Our final sample consisted of 25 patients subjected to RYGB and 11 to SG. Body mass index, fat-free mass, fat mass, PhA, serum transthyretin (TTR), albumin, C-reactive protein, alpha-1-acid glycoprotein, and prognostic inflammatory and nutritional indices were evaluated at four time points: before and approximately two, six, and 12 months after RYGB or SG. One-way repeated measures ANOVA or the Friedman test with Tukey's post hoc test was used depending on data distribution. The correlation between PhA and biochemical parameters and indices were evaluated using Spearman's or Pearson's correlation coefficients. Except for serum albumin, all parameters significantly decreased over time (p<0.001). Only the RYGB group showed transthyretinTR values below reference ones. Prognostic indices significantly decreased in both groups (p<0.001). We found a significant positive correlation of PhA with TTR in both RYGB (r=0.475; p<0.001) and SG (r=0.457; p<0.001). Data suggest that at a one-year follow-up after bariatric surgery, lower PhA values might indicate a concomitant loss of visceral protein and a worsening of protein nutritional status.

Effect of Enteral Nutrition on Postoperative Recovery in Patients with Appendicitis

By comparing the content of albumin and retinol-binding protein in patients with acute appendicitis before and after surgery, the effect of these two visceral proteins on patients' wounds was reviewed. In addition, after the use of enteral nutrition therapy, the content of anterior albumin and retinol-binding protein in patients was compared, and the effect of enteral nutrition on postoperative recovery in patients with appendicitis was explored. Methods: A review of 100 patients with acute appendicitis treated in the First People's Hospital of Yichang City, People's Hospital of China Three Gorges University from June 2016 to March 2018 was reviewed. Performs endoscopic appendectomy and traditional open appendectomy, respectively. Changes in PA and Bbp levels in patients before and after surgery are detected. After reviewing the patients with acute appendicitis diagnosed and surgically treated by general surgery of the Fifth Clinical Medical College of Yangzhou University, they were divided into two groups after surgery, which were given parenteral nutritional support and normal diet, and observed after a period of time to compare the visceral protein index in the blood with the postoperative healing speed. The relationship between parenteral nutrition and postoperative recovery rate of appendicitis was obtained.