Blue-violet Light Research Articles

Efficacy of Violet-Blue (405 nm) LED Lamps for Disinfection of High-Environmental-Contact Surfaces in Healthcare Facilities: Leading to the Inactivation of Microorganisms and Reduction of MRSA Contamination.

Effective disinfection procedures in healthcare facilities are essential to prevent transmission. Chemical disinfectants, hydrogen peroxide vapour (HPV) systems and ultraviolet (UV) light are commonly used methods. An emerging method, violet-blue light at 405 nm, has shown promise for surface disinfection. Its antimicrobial properties are based on producing reactive oxygen species (ROS) that lead to the inactivation of pathogens. Studies have shown significant efficacy in reducing bacterial levels on surfaces and in the air, reducing nosocomial infections. The aim of this study was to evaluate the antimicrobial effectiveness of violet-blue (405 nm) LED lamps on high-contact surfaces in a hospital infection-control laboratory. High-contact surfaces were sampled before and after 7 days of exposure to violet-blue light. In addition, the effect of violet-blue light on MRSA-contaminated surfaces was investigated. Exposure to violet-blue light significantly reduced the number of bacteria, yeasts and moulds on the sampled surfaces. The incubator handle showed a low microbial load and no growth after irradiation. The worktable and sink showed an inconsistent reduction due to shaded areas. In the second experiment, violet-blue light significantly reduced the microbial load of MRSA on surfaces, with a greater reduction on steel surfaces than on plastic surfaces. Violet-blue light at 405 nm has proven to be an effective tool for pathogen inactivation in healthcare settings Violet-blue light shows promise as an additional and integrated tool to reduce microbial contamination in hospital environments but must be used in combination with standard cleaning practices and infection control protocols. Further research is needed to optimise the violet-blue, 405 nm disinfection method.

Metabolomics evaluation of the photochemical impact of violet-blue light (405nm) on ex vivo platelet concentrates.

Microbicidal violet-blue light in the visible spectrum (405nm) has been under evaluation for pathogen inactivation in ex vivo human plasma and platelets (PLTs) stored in plasma. Results to date have demonstrated that several blood-borne infectious disease-causing pathogens can be successfully reduced to significantly low levels in the light-treated plasma and PLTs. In order to evaluate whether the microbicidal 405nm light is safe for the treatment of PLT concentrates for pathogen inactivation, LC/MS-based metabolomics analyses were performed to evaluate the overall impact of 405nm violet-blue light treatment on ex vivo PLT concentrates suspended in plasma and on plasma itself, and to identify metabolome changes in intra-platelet and extra-cellular medium (i.e., plasma). The metabolomics data identified that platelet activating factors (PAFs), agonists and prostaglandins, which can influence PLT basic functions such as integrity, activation, and aggregation potential were unaltered, suggesting that 405nm light illumination is safe regarding PLT basic functions. Distinct increases in hydroxyl fatty acids and aldehydes, as well as decreases in antioxidant metabolites indicated that reactive oxygen species (ROS) were generated at high levels after only one hour of exposure to 405nm light. Distinctly changed endogenous photosensitizer metabolites after 1h of light exposure provided good evidence that 405nm light was an effective microbicide acting through ROS mechanism and no external additive photosensitizers were required.

An investigation of the influence of reactive oxygen species produced from riboflavin-5′-phosphate by blue or violet light on the inhibition of WiDr colon cancer cells

Riboflavin-5′-phosphate (FMN), an innocuous product of riboflavin (RF) phosphorylation, is vital for humans. FMN is sensitive to light illumination, as indicated by reactive oxygen species (ROS) formation. This investigation was undertaken to evaluate the influence of blue light illumination (BLI) and violet light illumination (VLI) upon FMN to develop a method to inhibit WiDr colon cancer cells by FMN photolysis. When FMN is subjected to BLI and VLI, it inhibits WiDr colon cancer cells by generating superoxide radical anions (O2•−). The respective reduction rates are 42.6 and 81.9 % in WiDr colon cancer cells for FMN treated with BLI and VLI at 20 W/m2 for 0.5 h. FMN treated with VLI inhibits WiDr colon cancer cells more effectively than BLI. Propidium iodide (PI) is a fluorescent dye that is used to detect abnormal DNA due to cell death by apoptosis or necrosis. The PI-positive count for nuclei increased significantly for the WiDr colon cancer cells that were treated with FMN under VLI at 20 W/m2 for 0.5 h. FMN photolysis achieved using VLI allows efficient photodynamic therapy (PDT) by triggering the cytotoxicity of FMN on WiDr colon cancer cells.

Escherichia coli-Based In Situ Triggerable Probe as an Amplifier for Sensitive Diagnosis and Penetrated Therapy of Cancer.

Escherichia coli (E. coli) was used for cancer therapy due to the tumor-targeting, catalytic, and surface-reducing properties. Effective diagnosis combined with treatment of cancer based on E. coli, however, was rarely demonstrated. In this study, E. coli was used to surface reduce HAuCl4 and as a carrier to modify riboflavin (Rf) and luminol (E-Au@Rf@Lum). After targeted delivery to tumor, the E-Au@Rf@Lum probe could actively emit 425 nm blue-violet chemiluminescence (CL) to achieve cell imaging for cancer diagnosis. Furthermore, this light could in situ trigger the photosensitizer (Rf) through CL resonance energy transfer, which produces reactive oxygen species (ROS) for accurate photodynamic therapy. In return, the excessive ROS enhanced the blue-violet light which was further absorbed by Rf, and ROS production was cyclically amplified. Abundant ROS broke down the dense extracellular matrix network and penetrated deep into tumors. Besides, E. coli with excellent catalytic property could decompose H2O2 to O2 to relieve tumor hypoxia for a long time and enhance the photosensitized process of Rf. By self-illumination, effective penetration, and tumor hypoxia relief, this work opens a self-amplified therapy modality to tumor.

Photodynamic inactivation of multidrug-resistant strains of Klebsiella pneumoniae and Pseudomonas aeruginosa in municipal wastewater by tetracationic porphyrin and violet-blue light: The impact of wastewater constituents.

There is an increasing need to discover effective methods for treating municipal wastewater and addressing the threat of multidrug-resistant (MDR) strains of bacteria spreading into the environment and drinking water. Photodynamic inactivation (PDI) that combines a photosensitiser and light in the presence of oxygen to generate singlet oxygen and other reactive species, which in turn react with a range of biomolecules, including the oxidation of bacterial genetic material, may be a way to stop the spread of antibiotic-resistant genes. The effect of 5,10,15,20-(pyridinium-3-yl)porphyrin tetrachloride (TMPyP3) without light, and after activation with violet-blue light (VBL) (394 nm; 20 mW/cm2), on MDR strains of Pseudomonas aeruginosa, Klebsiella pneumoniae and K. pneumoniae OXA-48 in tap water and municipal wastewater was investigated. High toxicity (~2 μM) of TMPyP3 was shown in the dark on both strains of K. pneumoniae in tap water, while on P. aeruginosa toxicity in the dark was low (50 μM) and the PDI effect was significant (1.562 μM). However, in wastewater, the toxicity of TMPyP3 without photoactivation was much lower (12.5-100 μM), and the PDI effect was significant for all three bacterial strains, already after 10 min of irradiation with VBL (1.562-6.25 μM). In the same concentrations, or even lower, an anti-adhesion effect was shown, suggesting the possibility of application in biofilm control. By studying the kinetics of photoinactivation, it was found that with 1,562 μM of TMPyP3 it is possible to achieve the complete destruction of all three bacteria after 60 min of irradiation with VBL. This study confirmed the importance of studying the impact of water constituents on the properties and PDI effect of the applied photosensitiser, as well as checking the sensitivity of targeted bacteria to light of a certain wavelength, in conditions as close as possible to those in the intended application, to adjust all parameters and perfect the method.

An elastic luminescent organic single crystal with linear and nonlinear optical waveguide properties

In recent years, organic single crystals combining elastic and photoluminescent (PL) properties have attracted extensive attention due to their promising applications in many fields. However, elastic organic crystals with two-photon luminescence (2 PL) waveguiding properties are still rarely found, which is imperative for various applications, including near-infrared (NIR) bioimaging and nonlinear optical (NLO) photonic devices. This work reports an elastic single crystal with a long needle shape, anthracene-9,10-dicarbaldehyde (An-DC). Its crystal (100) face exhibits highly reversible bending by applying the mechanical force, which is facilitated by the van der Waals (C– H···π), H-bond (C–H⋯O), and π···π interactions among molecules. The crystal emits a strong orange-red fluorescence when excited by blue-violet light. Interestingly, it also exhibits excellent two-photon fluorescence emission when stimulated by near-infrared light. Based on these linear and nonlinear optical characteristics, the waveguide applications of the An-DC crystal were implemented. Notably, in the bending state, the luminescence performance and the crystal structure of the An-DC crystal are maintained well, which can be used as a low-loss material for linear and nonlinear optical waveguide devices, thus expanding the potential use of flexible organic crystals.

Higher seed maturity levels, darker pericarp, and smaller seed size relate to improved damping-off tolerance in spinach

With the growing demand for baby-leaf spinach (Spinacia oleracea L.) and an increasing ban on chemical seed treatments, problems of damping-off diseases become more apparent. Pythium ultimum has been shown to be the most common damping-off pathogen of spinach. Previous studies showed a large variation in pre-emergence damping-off tolerance levels among seed lots of spinach cultivars, which did not correlate with the rate of seedling emergence. In this study, we analysed if individual seed vigor-related traits, such as seed size and maturity, can influence seed tolerance towards pre-emergence infection by P. ultimum. Seeds of the same seed lots were measured for their morphological and multispectral properties on the level of a single seed. The seedling emergence from those individual seeds was assessed at different P. ultimum doses and for each individual seed, the characteristics were correlated with its emergence success. The results showed that relatively higher levels of chlorophyll fluorescence, an indicator of lesser seed maturity, had a negative association with emergence success. With increasing P. ultimum dose, the seed size and light reflectance from the pericarp, particularly with violet-blue light, showed an increasingly negative association with emergence. This indicated that smaller seeds and seeds that reflected less (violet-blue) light were more tolerant towards P. ultimum infection. A validation study with seed size and maturity fractions of a single seed lot (excluding potential genotypic and seed production effects) confirmed that seed maturity had a positive association with seedling emergence, and that seed size had a negative association with the emergence in the presence of P. ultimum. Seed size and light reflectance accounted for a small part of the variation in P. ultimum tolerance among the seed lots. Selecting the most mature seeds with relatively less light reflectance (darker pericarp) or mature seeds with smaller sizes is recommended to obtain seed lots with improved pre-emergence damping-off tolerance levels.

Laboratory evaluation of the broad-spectrum antibacterial efficacy of a low-irradiance visible 405-nm light system for surface-simulated decontamination

PurposeLighting systems which use visible light blended with antimicrobial 405-nm violet-blue light have recently been developed for safe continuous decontamination of occupied healthcare environments. This paper characterises the optical output and antibacterial efficacy of a low irradiance 405-nm light system designed for environmental decontamination applications, under controlled laboratory conditions.MethodsIn the current study, the irradiance output of a ceiling-mounted 405-nm light source was profiled within a 3×3×2 m (18 m3) test area; with values ranging from 0.001-2.016 mWcm-2. To evaluate antibacterial efficacy of the light source for environmental surface decontamination, irradiance levels within this range (0.021-1 mWcm-2) at various angular (Delta ϴ=0-51.3) and linear (∆s=1.6-2.56 m) displacements from the source were used to generate inactivation kinetics, using the model organism, Staphylococcus aureus. Additionally, twelve bacterial species were surface-seeded and light-exposed at a fixed displacement below the source (1.5 m; 0.5 mWcm-2) to demonstrate broad-spectrum efficacy at heights typical of high touch surfaces within occupied settings.ResultsResults demonstrate that significant (P≤0.05) inactivation was successfully achieved at all irradiance values investigated, with spatial positioning from the source affecting inactivation, with greater times required for inactivation as irradiance decreased. Complete/near-complete (≥93.28%) inactivation of all bacteria was achieved following exposure to 0.5 mWcm-2 within exposure times realistic of those utilised practically for whole-room decontamination (2-16 h).ConclusionThis study provides fundamental evidence of the efficacy, and energy efficiency, of low irradiance 405-nm light for bacterial inactivation within a controlled laboratory setting, further justifying its benefits for practical infection control applications.

The impacts of green LaBSiO<sub>5</sub>: Tb<sup>3+</sup>, Ce<sup>3+</sup> phosphor on lumen output of white LEDs

The traditional solid-state technique was used to create LaBSiO5 phosphors doped with Ce3+ and Tb3+ at 1,100 °C. These phosphors' phase purity and luminous characteristics are looked at. Under ultraviolet (UV) light stimulation, LaBSiO5: Tb3+ phosphors emit bright green light, whereas LaBSiO5 samples incorporated with Ce3+ emit blue-violet light. With UV ray stimulation, LaBSiO5 samples incorporated with Ce3+ as well as Tb3+ emit blue-violet as well as green illumination. The 5d-4f shift for Ce3+ is responsible for the blue-violet radiation, while the 5D4→7F5 transition of Tb3+ is responsible for the green radiation. The mechanism for power conversion between Ce3+ and Tb3+ was examined since there is a spectral overlap among the stimulation line for Tb3+ and the emitting line for Ce3+.

Fine adjustment of emission wavelength, light-conversion quality, photostability of blue-violet light conversion agents based on FRET effect

Single fluorescent chromophore is difficult to achieve efficient photoecological effect, meanwhile, the cost of light conversion agent should be more strictly controlled, thereby promoting the large-scale application of light conversion agricultural film. To solve the above problems, three carbazole derivatives CZ, TCZ and MCZ as donors of Förster resonance energy transfer, and the tris(carbazolyl) substituted triazine TPT as an acceptor of Förster resonance energy transfer, were designed and synthesized. Based on absorption and emission spectra, aggregation induced emission experiments, and light conversion quality tests, the best formulation of light conversion film are obtained. Among of them, TCZ@0.2TPT@EVAb and MCZ@0.2TPT@EVAb films (40% ethylene vinyl alcohol copolymer defined as EVAb film) show highest photosynthetic photon flux density at 400–500 nm, and matching fluorescence emission (458 nm and 461 nm). Under 20 h of intensified ultraviolet radiation (365 nm, 40 W), the emission intensity of TCZ@0.2TPT@EVAb and MCZ@0.2TPT@EVAb films can maintain over 94% of the initial value, showing excellent photostability. Compared with the blank EVAa/EVAb film, the transmittance of the doping films at 500–600 nm are up to 95.12%–99.64%, meaning excellent compatibility and dispersion of light conversion agent in doping films. It is worth mentioning that emission maxima of doping films can be continuously adjusted within the spectral range 430–480 nm, which is conducive to meet the photoecological needs of different crops. Finally, the doping films show low transmittance (1.78%–11.42%) at 200–350 nm, outlining excellent UV light conversion properties.

Intense millisecond-long red luminescence from heteroleptic Cu(I) 2,1,3-benzothiadiazole complexes

Intense red-emitting heteroleptic Cu(I) complexes were isolated using 2,1,3-benzothiadiazole (BTD) as N-donor ligand and triphenylphosphine, bis[(2-diphenylphosphino)phenyl] ether (DPEphos) or bis(diphenylphosphino)methane (dppm) as P-donors. The structures of two mononuclear and one dinuclear derivatives with one nitrogen and two phosphorus atoms in the Cu(I) coordination sphere were ascertained by means of X-ray diffraction, revealing an overall tetrahedral geometry at the solid state due to the direct interaction of the counterion with Cu(I). Upon excitation with UV and violet-blue light, the Cu(I) complexes exhibited emissions centred between 623 and 683 nm with photoluminescence quantum yields up to 46%. Lifetimes in the tens-thousands millisecond range were observed. The values resulted affected by the choice of the counterion, and an increase of up to 15% was observed passing from tetrafluoroborate to perchlorate in the mononuclear BTD complex with two PPh3 ligands. DFT calculations indicated that the lowest energy absorptions have charge transfer nature, from the {CuP2} fragments with the contributions of the P-bonded aryl substituents to an unoccupied π* orbital of BTD. The triplet→singlet emissions involve the metal centre, the phosphine ligands, and the occupied and empty orbitals of BTD.

Eu2+/Ce3+-doped NaAlSiO4 selective occupation-induced emission structure unit evolution and its luminescence characteristics

NaAlSiO4: xEu2+,yCe3+ blue-red phosphors were prepared by high-temperature melting-icy quenching-heat treatment. The effects of emission structure unit evolution, microstrain, microcrystalline size and selective occupation on the luminescence characteristics of the prepared phosphor were systematically studied by powder X-ray diffraction pattern (XRD) and photoluminescence spectroscopy (PL). In the structure of NaAlSiO4: 2%Eu2+, 2%Ce3+ hexagonal crystalline sodium nepheline, Eu2+ ions occupy the Na+ (II) position to form a EuNa+(II)2+ luminescent structure unit, and Ce3+ ions occupy the Na+ (I) position to form a CeNa+(I)3+ luminescent structure unit. The NaAlSiO4: 2%Eu2+/NaAlSiO4: 2%Ce3+ emits 555 nm yellow-green light/395 nm blue-violet light under the excitation of 354 nm/298 nm, respectively, which is derived from the 5d-4f transition of Eu2+ and Ce3+. There is energy transfer of Ce3+→Eu2+ in the sodium nepheline matrix, of which the transport pathway is m EuNa+(II)2+ ←O←n CeNa+(I)3+ →O→m EuNa+(II)2+, and the transport mechanism is electric quadrode-electric quadrupole interaction, and the energy transfer efficiency reaches 98.6%. The sodium nepheline NaAlSiO4: 2%Eu2+, 2%Ce3+ phosphor with energy level barrier 0.386 eV, possesses good thermal stability. This single-phase aluminosilicate multicolor phosphor has potential application value for WLED illumination and PDP display.

Developing techniques for the observation of nocturnal wildlife on a resort island as a collaboration between academia and microenterprises

This paper describes the development of methods for the observation of nocturnal wildlife as a collaborative effort between academia and microenterprises. A number of private firms have for many years been operating tours for wildlife watching on Green Island, and local guides have also worked with wildlife researchers. In accordance with government regulations, researchers and operators were tasked with developing new protocols for observing nocturnal wildlife to promote sustainability. We developed a system to capture images of biofluorescence using a blue-violet light source in which an optical filter is placed over a flashlight. The proposed scheme was shown to capture stunning images without causing harm to any of the species. The concepts of Action Research were employed to the whole innovation process. The relationships established between researchers and operators formed the basis of successful early collaborations. The interaction among local operators, academia, and government was conceptually modeled in six steps: initiation, analysis, design, construction, development, and implementation.

Antimicrobial 405nm violet-blue light treatment of ex vivo human platelets leads to mitochondrial metabolic reprogramming and potential alteration of Phospho-proteome.

Continued efforts to reduce the risk of transfusion-transmitted infections (TTIs) through blood and blood components led to the development of ultraviolet (UV) light irradiation technologies known as pathogen reduction technologies (PRT) to enhance blood safety. While these PRTs demonstrate germicidal efficiency, it is generally accepted that these photoinactivation techniques have limitations as they employ treatment conditions shown to compromise the quality of the blood components. During ex vivo storage, platelets having mitochondria for energy production suffer most from the consequences of UV irradiation. Recently, application of visible violet-blue light in the 400-470nm wavelength range has been identified as a relatively more compatible alternative to UV light. Hence, in this report, we evaluated 405nm light-treated platelets to assess alterations in energy utilization by measuring different mitochondrial bioenergetic parameters, glycolytic flux, and reactive oxygen species (ROS). Furthermore, we employed untargeted data-independent acquisition mass spectrometry to characterize platelet proteomic differences in protein regulation after the light treatment. Overall, our analyses demonstrate that ex vivo treatment of human platelets with antimicrobial 405nm violet-blue light leads to mitochondrial metabolic reprogramming to survive the treatment, and alters a fraction of platelet proteome.

Fabrication of MoS2/C60 Nanolayer Field-Effect Transistor for Ultrasensitive Detection of miRNA-155.

As a major public health issue, early cancer detection is of great significance. A field-effect transistor (FET) based on an MoS2/C60 composite nanolayer as the channel material enhances device performance by adding a light source, allowing the ultrasensitive detection of cancer-related miRNA. In this work, atomic layer deposition (ALD) was used to deposit MoS2 layer by layer, and C60 was deposited by an evaporation coater to obtain a composite nanolayer with good surface morphology as the channel material of the FET. Based on the good absorption of C60 by blue-violet light, a 405 nm laser was selected to irradiate the channel material, improving the function of FET biosensors. A linear detection window from 10 pM to 1 fM with an ultralow detection limit of 5.16 aM for miRNA-155 was achieved.

Controlled growth and spectroscopy characterization of blue violet perovskite quantum dots in borate glasses

Blue violet light emitting CsPb(Cl/Br)3 perovskite quantum dots glasses (QDGs) have been successfully fabricated in multi-component borate glass matrix by melt quenching and heat treatment. The spectral characteristics have been evaluated by photoluminescence (PL), PL excitation (PLE), PL decay and absorption spectra. The recipe and preparation conditions have been optimized for controlled growth of QDs. By using raw materials of NH4Br/NH4Cl/PbO and crucible cover, optimizing composition of Na2O/K2O in matrix, melting temperature and time, heat treatment temperature and time, and NH4Cl and NH4Br contents, we have finally realized blue violet exciton emission in target range of 405–440 nm. The PL wavelength adjustment is comprehensive effect of the abovementioned influence factors. The emission in short wavelength of 405–440 nm is due to controlled growth of the QDs. In final CsPb(Cl/Br)3 QDs, the contents of Cl and Br are suitable and the Cl/Br ratios are large. A little Br is necessary for growth of CsPb(Cl/Br)3 QDs and then the Br is partially replaced by Cl at suitable treatment condition. Unsymmetrical PL spectrum profile of some samples is explained as reabsorption effect by monitoring PL spectral profile and PL decay. The temperature characteristics of PL spectra show good recoverability after a temperature cycle.

Occlusal caries detection on 3D models obtained with an intraoral scanner. A validation study

ObjectivesTo evaluate the diagnostic performance of visual caries assessment on 3D dental models obtained using an intraoral scanner and to compare it with the performance of the clinical visual inspection. MethodsFifty-three permanent posterior teeth scheduled for extraction were randomly selected and included in this study. One to three independent examination sites on the occlusal surface of each tooth were clinically inspected using International Caries Detection and Assessment System (ICDAS) criteria. Afterwards, the examined teeth were scanned intraorally with a 3D intraoral scanner (TRIOS 4, 3Shape TRIOS A/S, Copenhagen, Denmark) using white and blue-violet light (415 nm wavelength) to capture the colour and fluorescence signal from the tissues. Six months after the clinical examination, the same examiner conducted the on-screen assessment of the obtained 3D digital dental models at the selected examination sites using modified ICDAS criteria. Both tooth colour and fluorescence texture with high resolution were assessed. Lastly, an independent examiner conducted the histological examination of all teeth after extraction. Using histology as the reference test, Sensitivity (SE), Specificity (SP), Accuracy (ACC), area under the Receiver Operating Characteristic (ROC) curve, and Spearman's correlation coefficient were calculated for the clinical and on-screen ICDAS assessments. ResultsThe ACC values of the evaluated methods varied between 0.59-0.79 for initial caries lesions and 0.77-0.99 for moderate-extensive caries lesions. Apart from SE values corresponding to caries in the inner half of enamel, no significant difference was observed between clinical visual inspection and on-screen assessment. In addition, no difference was found in the assessment of 3D models with tooth colour alone or supplemented with fluorescence for all the evaluated diagnostic measures. ConclusionsOn-screen visual assessment of 3D digital dental models with tooth colour or fluorescence showed a similar diagnostic performance to the clinical visual inspection when detecting and classifying occlusal caries lesions on permanent teeth. Clinical significance3D intraoral scanning can aid the detection and classification of occlusal caries as part of patient screening and can potentially be used in remote caries assessment for clinical and research purposes.

Review on the study of potential health hazards caused by blue light due to Melanopsin activity

Humans live in a 24-hour environment, in which light and darkness follow a diurnal pattern. In humans, the known effects of light on circadian rhythms and sleep are all, without exception, mediated by the retina. The retina is a fine layer of nerve tissue at the back of our eyes, containing specialized photoreceptors. Melanopsin RGCs are extremely sensitive to blue light and even exposure to light levels as low as the one from a smart-phone or light emitting e-readers are associated with disruptions of circadian rhythm. Melanopsin absorbs light in the short-wavelength range of the visible spectrum, with λmax at or near 480 nm. High-intensity blue light from any source is potentially hazardous to the eye. Industry sources of blue light are purposely filtered or shielded to protect users. However, it may be harmful to look directly at many high-power consumer LEDs simply because they are very bright. When Melanopsin is activated by the short wavelength component of light, it suppresses Melatonin synthesis. This action is controlled mainly by light could affect several functions including the regulation of intraocular pressure. Blue light or blue-violet light can be damaging to delicate retinal cells deep in the eye. No one knows exactly what causes dry macular degeneration. Research indicates that it may be a combination of family genes and environmental factors, including smoking, obesity and diet. The condition develops as the eye ages. Additionally, our studies have shown blue light is a risk factor for the onset of age-related macular degeneration, which is a progressive condition that can lead to vision loss over.

Tunable Emission Wavelength and Chromaticity Electroluminescence Realized in Ho Doped ZnO Microspheres Heterojunction

Tunable white light sources have huge potential applications in the scope of intelligent lighting or high-quality display system, but it is still a challenge to tune the emission wavelength and chromaticity in a simple structure. Herein, the Ho3+ doped ZnO microsphere was bonded onto the p-GaN substrate to form a heterojunctional light-emitting diode. Through a combination of the light confinement effect in the ZnO microsphere and multilevel emission system in rare earth materials, the device demonstrates tunable electroluminescence (EL) both in wavelength and chromaticity. The device shows broadband emission peak at 400 nm with full width at half maximum (FWHM) of 34 nm under forward pulsed driven bias. While it shows a series of sharp emissions from rare earth ions Ho3+ with peaks at 427 nm, 492 nm, 567 nm, 592 nm and 654 nm and FWHM less than 1.3 nm under reverse pulsed driven bias. More meaningful, the wavelength and chromaticity can be controlled with duty cycle or the rate of forward and reverse driven bias under intelligent programmable alternating current (AC) driven. Finally, the gradient from blueviolet light to white light can be realized.

Effects on Wavefront Aberration after Short-term Wear of Senofilcon A Photochromic Contact Lens.

To assess the variability in wavefront aberrations with short-term wear of photochromic senofilcon A contact lenses in both its activated and inactive states. In this cross-sectional study, 20 participants who had previously used soft contact lenses were enrolled. Corneal aberrometry measurements were performed on each subject, without contact lenses, using Sirius Scheimpflug-Placido topography. The photochromic lenses were illuminated using a blue-violet light (λ max = 420 nm) so as to provoke an activated state, and measurements were taken with the lenses inserted, in both states. The root mean square (RMS) of the aberrations was calculated, and the higher- and lower-order aberrations, astigmatism, coma, spherical aberration, and trefoil measurements were evaluated using a 5.0-mm pupil diameter. The average contact lens sphere power was - 2.33 ± 1.07 D. The mean refractive errors with contact lens wear were 0.07 ± 0.18 D for the sphere and - 0.26 ± 0.15 D for the cylinder. The mean RMS values for all the corneal aberrations showed no statistically significant differences with and without contact lenses (p > 0.05). In a bivariate correlation analysis, there was a positive correlation between contact lens sphere power and coma (vertical and horizontal) in the activated state (r = 0.455, p = 0.44 and r = 0.495, p = 0.27, respectively). The photochromic contact lenses did not influence ocular aberration during short-term wear, even when the photochromatic additive was activated. This property may help to provide more comfortable vision with lens wear. This finding needs to be verified by further studies.