Since it is possible for the nano-particle to have any asymmetric shape and may attach to every position of the resonator-based mass sensors, any type of mass eccentricity and subsequently coupled vibrations are possible. So, in the present work, the 3D coupled axial-torsional-flexural vibrations of the mass nano-sensors are investigated considering both in-plane and out-of-plane bending as well as axial and torsional vibrations. In addition, the integral form of the two-phase local/nonlocal strain gradient (LNSG), as the consistent type of the common nonlocal strain gradient (NSG) elasticity theory, is employed for the first time to consider the size effects in the mass nano-sensors. A quasi-3D coupled FE model is constructed with no shear-locking within the complicated environment of the integral LNSG. The impacts of the LNSG elasticity and diverse types of possible coupling in changing the vibrational behavior of the mass nano-sensor are scrutinized and their crucial role in modeling of the nano-sensors is indicated. Furthermore, molecular dynamic (MD) simulations are implemented to identify and analyze the coupled vibrations of a mass nano-sensor consisting of a fixed-free carbon nanotube. Comparison between the MD results with those of the present coupled FE model reveals that considering the coupling effects reduces the modeling error, especially in the cases in which the coupling influences intensify. The present work can help to provide more accurate models of mechanical resonance-based nanosensors to detect nanoparticles with different shapes, larger sizes, and high mass ratios, which can lead to achieving sensors with higher sensitivity.
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