Abstract This paper presents a nonlinear interface circuit for piezoelectric vibration energy harvester (PEH) with Synchronous Asymmetric Voltage Flipping and Charge Extraction process, denoted as SAFCE. SAFCE flips the PEH voltage polarity at positive peak and completely extracting charge at negative peak through LC resonance. The harvested power is independent of load. In theory, the harvested power is 200 % of SECE and 780 % of best impedance-matched SEH due to the energy injection mechanism, which enhances the electromechanical coupling coefficient of PEH. Moreover, a self-powered SAFCE circuit without rectifier bridge is designed, which reduces power consumption and eliminates the need for external power sources. Experimental measurements are carried out to compare with SEH and SECE circuits under the condition of either constant displacement magnitude (0.5 mm) or constant external excitation acceleration (10 m/s2). The experimental results indicate that the power harvested by the SAFCE technique increased by 171 % compared with the SECE method and by 381 % compared with the best impedance-matched SEH method under the same conditions.