Borehole samples were collected from a municipal solid waste (MSW) landfill in Xi'an, China, and subjected to a series of basic geotechnical and compression tests. This study aims to investigate the influence of composition, dry unit weight, moisture content, organic content, and landfill age on the compressibility of MSW. The results show that with increasing landfill age, the compressible components and organic content exhibit a decreasing trend while the dry unit weight increases. The moisture content does not vary significantly. There is also a linear trend between the logarithm of the primary compression strain and vertical stress. In addition, with an increase in compressible components content, moisture content, and organic content, the modified primary compression index (Cc') shows an increasing trend, whereas with an increase in dry unit weight and landfill age, Cc' shows a decreasing trend. Furthermore, regarding the 34 sets of data, authors only selected five data points for a detailed comparative analysis, this decision was made on the basis that these data points are representative. A modified primary compression index prediction model that considers the dry unit weight, moisture content, and landfill age of the MSW as influencing factors results in a fitting coefficient of 0.797. The Cc' values in this study are within the range of 0.12 to 0.36. These findings provide a reference for the vertical expansion design of existing landfills.