Vertical Gratings Research Articles

Intra- and inter-hemispheric processing during binocular rivalry in mild glaucoma.

Glaucoma is considered a progressive optic neuropathy because of the damage and death of the retinal ganglion cells. It is also a neurodegenerative disease because it affects neural structures in the visual system and beyond, including the corpus callosum–the largest white matter structure involved in inter-hemispheric transfer of information. In this study we probed the dysfunction of the inter-hemispheric processing in patients with mild glaucoma using the phenomenon of binocular rivalry. Patients with mild glaucoma and no measurable visual field defects and age-matched controls underwent a thorough visual assessment. Then they participated in a series of psychophysical tests designed to examine the binocular rivalry derived from intra- and inter-hemispheric processing. Static horizontal and vertical sinewave gratings were presented dichoptically using a double-mirror stereoscope in 3 locations: centrally, to probe inter-hemispheric processing, and peripherally to the left or to the right, to probe intra-hemispheric processing. Although the two groups were matched in functional measures, rivalry rate of the glaucoma group was significantly lower than that of the control group for the central location, but not for the peripheral location. These results were driven mainly by the patients with normal tension glaucoma whose average rivalry rate for the central location (from which information reaches the two hemispheres) was almost half (46% lower) that of the controls. These results indicate a dysfunction in inter-hemispheric transfer in mild glaucoma that can be detected behaviourally before any changes in standard functional measures.

Short-latency ocular-following responses: Weighted nonlinear summation predicts the outcome of a competition between two sine wave gratings moving in opposite directions.

We recorded horizontal ocular-following responses to pairs of superimposed vertical sine wave gratings moving in opposite directions in human subjects. This configuration elicits a nonlinear interaction: when the relative contrast of the gratings is changed, the response transitions abruptly between the responses elicited by either grating alone. We explore this interaction in pairs of gratings that differ in spatial and temporal frequency and show that all cases can be described as a weighted sum of the responses to each grating presented alone, where the weights are a nonlinear function of stimulus contrast: a nonlinear weighed summation model. The weights depended on the spatial and temporal frequency of the component grating. In many cases the dominant component was not the one that produced the strongest response when presented alone, implying that the neuronal circuits assigning weights precede the stages at which motor responses to visual motion are generated. When the stimulus area was reduced, the relationship between spatial frequency and weight shifted to higher frequencies. This finding may reflect a contribution from surround suppression. The nonlinear interaction is strongest when the two components have similar spatial frequencies, suggesting that the nonlinearity may reflect interactions within single spatial frequency channels. This framework can be extended to stimuli composed of more than two components: our model was able to predict the responses to stimuli composed of three gratings. That this relatively simple model successfully captures the ocular-following responses over a wide range of spatial/temporal frequency and contrast parameters suggests that these interactions reflect a simple mechanism.

Adjoint Optimization of Efficient CMOS-Compatible Si-SiN Vertical Grating Couplers for DWDM Applications

Data communication in silicon photonic interconnects requires efficient and broadband on/off-chip coupling components. Recently, perfectly vertically-emitting grating couplers have been proposed to increase spatial I/O density of the optical link and potentially improve manufacturing costs and ease of optical beam characterization. In this article, adjoint optimization was leveraged in the design of low-loss single (silicon) and dual layer (silicon + silicon nitride) perfectly-vertical grating couplers that are compatible with a scalable silicon-on-insulator (SOI) platform for the 65 nm CMOS technology node. In simulation, the best design peaks at −0.52 dB insertion loss with a 1 dB-bandwidth of 24 nm at the 1310 nm datacom wavelength.

Threshold Determination Criterion in Steady-State Visual Evoked Potential-Based Acuity Assessment: A Comparison of Four Common Methods

The steady-state visual evoked potential (SSVEP) visual acuity is usually defined by extrapolating a straight line regressed through significant SSVEP amplitudes plotted versus spatial frequencies to 0 μV or a noise level floor, or the finest spatial frequency evoking a significant SSVEP. This study aimed to compare the performance of the commonly used threshold determination criteria of the extrapolation technique and the finest spatial frequency technique. Visual acuity was measured both by the Freiburg Visual Acuity Test (FrACT) and SSVEP with vertical sinusoidal reversal gratings in ten adults. The extrapolation technique including three methods of linear extrapolation to zero (C <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> ), linear extrapolation to noise level baseline (C <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ) and linear extrapolation to zero versus log spatial frequency (C <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> ), and the finest spatial frequency technique with significance determination by canonical correlation analysis (CCA) and “OR”operation (C <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> ) were used to determine the SSVEP visual acuity. Bland-Altman method found a pretty good agreement between the SSVEP and FrACT acuity obtained by all the four threshold estimation criteria. One-way repeated-measures ANOVA and Bonferroni post-hoc analysis found that there was no significant difference among visual acuities measured by FrACT and all the four criteria, except for the visual acuity estimated by C <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> slightly higher than that of C <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> , demonstrating that these visual acuity estimating methods had a similar performance in evaluating the visual function. The correlation and agreement between subjective FrACT acuity and objective SSVEP acuity measured by four criteria respectively were all pretty good, demonstrating that all of these four threshold estimation criteria had a good performance in SSVEP visual acuity assessment.

Fly eyes are not still: a motion illusion in Drosophila flight supports parallel visual processing.

Most animals shift gaze by a 'fixate and saccade' strategy, where the fixation phase stabilizes background motion. A logical prerequisite for robust detection and tracking of moving foreground objects, therefore, is to suppress the perception of background motion. In a virtual reality magnetic tether system enabling free yaw movement, Drosophila implemented a fixate and saccade strategy in the presence of a static panorama. When the spatial wavelength of a vertical grating was below the Nyquist wavelength of the compound eyes, flies drifted continuously and gaze could not be maintained at a single location. Because the drift occurs from a motionless stimulus - thus any perceived motion stimuli are generated by the fly itself - it is illusory, driven by perceptual aliasing. Notably, the drift speed was significantly faster than under a uniform panorama, suggesting perceptual enhancement as a result of aliasing. Under the same visual conditions in a rigid-tether paradigm, wing steering responses to the unresolvable static panorama were not distinguishable from those to a resolvable static pattern, suggesting visual aliasing is induced by ego motion. We hypothesized that obstructing the control of gaze fixation also disrupts detection and tracking of objects. Using the illusory motion stimulus, we show that magnetically tethered Drosophila track objects robustly in flight even when gaze is not fixated as flies continuously drift. Taken together, our study provides further support for parallel visual motion processing and reveals the critical influence of body motion on visuomotor processing. Motion illusions can reveal important shared principles of information processing across taxa.

How exogenous spatial attention affects visual representation.

Orienting covert spatial attention to a target location enhances visual sensitivity and benefits performance in many visual tasks. How these attention-related improvements in performance affect the underlying visual representation of low-level visual features is not fully understood. Here we focus on characterizing how exogenous spatial attention affects the feature representations of orientation and spatial frequency. We asked observers to detect a vertical grating embedded in noise and performed psychophysical reverse correlation. Doing so allowed us to make comparisons with previous studies that utilized the same task and analysis to assess how endogenous attention and presaccadic modulations affect visual representations. We found that exogenous spatial attention improved performance and enhanced the gain of the target orientation without affecting orientation tuning width. Moreover, we found no change in spatial frequency tuning. We conclude that covert exogenous spatial attention alters performance by strictly boosting gain of orientation-selective filters, much like covert endogenous spatial attention.

Evaluating visual neuroplasticity with EEG in schizophrenia outpatients

Deficient neuroplasticity has been implicated in schizophrenia and can be examined with non-invasive methods in humans. High frequency visual stimulation (HFS) induces neuroplastic changes in visual evoked potential (VEP) components, similar to the tetanizing electrical stimulation that induces synaptic long-term potentiation (LTP). While visual HFS paradigms have been used in schizophrenia, the use of a single visual stimulus has precluded demonstration of whether the plasticity effects are specific to the stimulus presented during HFS (i.e., input specific). Additionally, test-retest reliability of VEP plasticity effects, an important consideration for applications of HFS paradigms in schizophrenia clinical trials, remains unknown. Accordingly, we administered a visual HFS paradigm to 38 schizophrenia patients and 27 healthy controls at baseline and two-weeks later. VEPs were elicited by horizontal and vertical line gratings before and after HFS; only one orientation was tetanized with HFS. Using a mass univariate permutation approach, we identified an input-specific cluster across groups that was broadly distributed over parietal-occipital areas between 108 and 183 ms. However, the groups did not differ in terms of the strength of plasticity effect. The test-retest reliability of the input-specific plasticity effect was modest over two weeks, suggesting that this HFS paradigm requires further development before it could be used to track plasticity change in clinical trials. Moreover, while the current HFS paradigm induced significant input-specific neuroplasticity, it did not replicate prior studies showing deficient neuroplasticity in schizophrenia. Accordingly, demonstration of deficient visual LTP-like neuroplasticity in schizophrenia may depend on paradigm parameters that remain to be fully elucidated.

Switchable pupil expansion propagation using orthogonal superposition varied-line-spacing H-PDLC gratings in a holographic waveguide system.

To solve the problem of small field of view in traditional holographic waveguides, this paper proposes a waveguide-coupling technique using orthogonal superposition varied-line-spacing (VLS) gratings. These gratings expand the x and y directions and orthogonally superimpose to achieve transmission in a waveguide and enlarge the pupil field of view. At the optical coupling input end and the coupling output end of a waveguide, one-dimensional VLS gratings are used to realize horizontal expansion of the image. Then a vertical VLS grating is orthogonally superimposed at the exit end to realize vertical expansion of the image. Finally, the waveguide transmission and expansion of the image are completed. In the experiment, holographic polymer dispersed liquid crystal one-dimensional VLS gratings in the x and y directions are fabricated and coupled with a waveguide. An image source with a diameter of 0.5cm is waveguide-transferred and coupled out, and then passed through the vertical grating. Amplification is performed to obtain an expanded image of a diameter of 2.28cm. In this study, the diffraction characteristics of the grating used to realize pupil expansion in the holographic waveguide system are analyzed and simulated. It is calculated that the diffraction efficiency of the VLS gratings can reach 80% or more in the 532nm band. Additionally, the characteristics of an electronically controlled switch are studied. Experimental results show that the method can be used for expanding the field of view and can be applied to waveguide systems for image transmission and expansion.

Spectral Correlation Between 2D and 1D Guided Mode Resonant Filters

We demonstrate the spectral responses of the guided mode resonant filter (GMRF) with 2D and 1D gratings, aiming to comprehensively investigate the spectral correlation between them under different incident conditions. A second-order effective-medium theory (EMT) is applied to calculate the effective refractive index of the corresponding 1D grating. Results show that the reflectance spectra of the 2D GMRF are considered to be a composition of that in two 1D GMRF structures with vertical grating bar orientation. The physical mechanism behind the spectral correlation is also analyzed in detail in terms of the wave vectors. Results and method shown in this letter provide a means to study new features of 2D GMRF, including the high angular tolerance, polarization-insensitivity under oblique incidence, and wavelength tunability.

On-chip 1 by 8 coarse wavelength division multiplexer and multi-wavelength source on ultra-silicon-rich nitride.

An 8-channel coarse wavelength division multiplexer (CWDM) based on coupled vertical gratings has been designed, fabricated and characterized. The devices are implemented on the ultra-silicon-rich nitride (USRN) platform. The demonstrated device possesses 8 CWDM channels. The absence of free spectral range (FSR) enabled the overall multiplexed bandwidth to span across the S + C + L bands. The CWDM channels meet the specifications stipulated by the International Telecommunications Union G.694.2 standard. The average channel crosstalk is -25dB. Pseudo-Random Bit Sequence 231-1 Non-Return-Zero data at 30Gb/s was launched into the device and a clear eye diagram was obtained. The device was further used with a USRN waveguide generating supercontinuum to create a multi-wavelength source emitting light at 8 CWDM wavelengths.

Effect of Interocular Contrast Difference on Stereopsis in Observers With Sensory Eye Dominance.

PurposeWe investigated how sensory eye dominance (SED) affects stereopsis when the half-images of random-dot-stereo stimuli had different interocular contrast.MethodsWe measured crossed and uncrossed stereo disparity thresholds and reaction time to seeing random-dot-stereograms with variable interocular contrast differences (ICD), where ICD = (log10 [CLE] − log10 [CRE]) = −0.4, −0.2, 0, 0.2, or 0.4 log unit. The mean contrast of the stimuli, (log10 [CLE] + log10 [CRE])/2, remained constant at 1.2 log unit to ensure that the measured effect was solely due to ICD. We also measured SED using, respectively, dichoptic horizontal sine wave gratings with different phases (revealing SEDcombo) and dichoptic vertical and horizontal gratings (revealing SEDinhibition).ResultsBoth measures of SEDinhibition and SEDcombo revealed the observers had the same eye as dominant although the magnitudes differed. The observers had lower stereo thresholds and shorter stereo reaction time on stimuli with unequal interocular contrast when the non–sensory-dominant eye viewed the higher contrast half-image, suggesting a stimulus-compensating effect. We then estimated the ICD of random-dot-stereo half-images (compensating stimuli) that would lead to minimum stereo threshold (SEDstereo-threshold) and reaction time (SEDstereo-RT) based on the stereo performance and ICD relationship, and found that they were significantly smaller than SEDinhibition and SEDcombo.ConclusionsBy linking SEDinhibition and SEDcombo with the effect of ICD on stereopsis, we provided further support for the notion that the stimulus-compensating effect is mediated by the interocular inhibitory and interocular gain control mechanisms. Furthermore, the interocular contrast for SEDstereo-threshold and SEDstereo-RT can be potentially applied for improving stereopsis in individuals with SED.

Electrophysiological and Psychophysical Studies of Meridional Anisotropies in Children With and Without Astigmatism.

We investigated the pattern of meridional anisotropies, if any, for pattern onset-offset visual evoked potential (POVEPs) responses and psychophysical grating acuity (GA) in children with normal letter visual acuity (20/20 or better). A total of 29 children (aged 3-9 years), nine of whom were astigmatic (AS), were recruited. Orientation-specific monocular POVEPs were recorded in response to sinewave grating stimuli oriented along the subjects' principal AS meridians. Horizontal and vertical gratings were designated Meridians 1 and 2, respectively, for nonastigmatic patients (Non-AS). Binocular POVEPs in response to the same stimuli, but oriented at 45°, 90°, 135°, and 180°, were recorded. Psychophysical GAs were assessed monocularly and binocularly along the same meridians using the same stimuli by a 2-alternative-forced-choice staircase technique. The C3 amplitudes and peak latencies of the POVEP and GAs were compared across meridians using linear mixed models (monocular) and ANOVA (binocular). There were significant meridional anisotropies in monocular C3 amplitudes regardless of astigmatism status (P = 0.001): Meridian 2 (mean ± SE Non-AS, 30.13 ± 2.07 μV; AS, 26.53 ± 2.98 μV) was significantly higher than Meridian 1 (Non-AS, 26.14 ± 1.87 μV; AS, 21.68 ± 2.73 μV; P = 0.019), but no meridional anisotropies were found for GA or C3 latency. Binocular C3 amplitude in response to horizontally oriented stimuli (180°, 29.71 ± 3.06 μV) was significantly lower than the oblique (45°, 36.62 ± 3 .05 μV; P = 0.03 and 135°, 35.95 ± 2.92 μV; P = 0.04) and vertical (90°, 37.82 ± 3.65 μV; P = 0.02) meridians, and binocular C3 latency was significantly shorter in response to vertical than oblique gratings (P ≤ 0.001). Meridional anisotropy was observed in children with normal vision. The findings suggest that horizontal gratings result in a small, but significantly lower POVEP amplitude than for vertical and oblique gratings.

Utilization of the high spatial-frequency component in adaptive beam shaping by using a virtual diagonal phase grating

A square flattop beam is a fundamental shape that is in high demand in various applications, such as ultra-high-power lasers, uniform surface processing and medical engineering. In this experiment, a new and simple scheme of the adaptive beam shaping system to generate a square flattop shape with high uniformity and edge steepness using virtual diagonal phase grating encoded on a spatial-light modulator and a 4f system is proposed. The grating vector kg is non-parallel to the normal vectors kx and ky of the objective beam profile to be extracted; thus, the residual and extracted components hit separately on the Fourier plane of the 4f system. Consequently, using a spatial-frequency filter passing components parallel to kx and ky, the residual components are blocked by the filter without loss of the high spatial-frequency domain of the extracted component. When the width of the filter was 1.0 mm, the edge of the shaped beam increased in height within 20 μm, which is less than 20% of that obtained with conventional vertical phase grating.

Miniaturisation reduces contrast sensitivity and spatial resolving power in ants.

Vision is crucial for animals to find prey, locate conspecifics and navigate within cluttered landscapes. Animals need to discriminate objects against a visually noisy background. However, the ability to detect spatial information is limited by eye size. In insects, as individuals become smaller, the space available for the eyes reduces, which affects the number of ommatidia, the size of the lens and the downstream information-processing capabilities. The evolution of small body size in a lineage, known as miniaturisation, is common in insects. Here, using pattern electroretinography with vertical sinusoidal gratings as stimuli, we studied how miniaturisation affects spatial resolving power and contrast sensitivity in four diurnal ants that live in a similar environment but vary in their body and eye size. We found that ants with fewer and smaller ommatidial facets had lower spatial resolving power and contrast sensitivity. The spatial resolving power was maximum in the largest ant Myrmecia tarsata at 0.60cyclesdeg-1 compared with that of the ant with smallest eyes Rhytidoponera inornata at 0.48cyclesdeg-1 Maximum contrast sensitivity (minimum contrast threshold) in M. tarsata (2627 facets) was 15.51 (6.4% contrast detection threshold) at 0.1cyclesdeg-1, while the smallest ant R. inornata (227 facets) had a maximum contrast sensitivity of 1.34 (74.1% contrast detection threshold) at 0.05cyclesdeg-1 Miniaturisation thus dramatically decreases maximum contrast sensitivity and also reduces spatial resolution, which could have implications for visually guided behaviours. This is the first study to physiologically investigate contrast sensitivity in the context of insect allometry.

Human-like perceptual masking is difficult to observe in rats performing an orientation discrimination task.

Visual masking occurs when the perception of a brief target stimulus is affected by a preceding or succeeding mask. The uncoupling of the target and its perception allows an opportunity to investigate the neuronal mechanisms involved in sensory representation and visual perception. To determine whether rats are a suitable model for subsequent studies of the neuronal basis of visual masking, we first demonstrated that decoding of neuronal responses recorded in the primary visual cortex (V1) of anaesthetized rats predicted that orientation discrimination performance should decline when masking stimuli are presented immediately before or after oriented target stimuli. We then trained Long-Evans rats (n = 7) to discriminate between horizontal and vertical target Gabors or gratings. In some trials, a plaid mask was presented at varying stimulus onset asynchronies (SOAs) relative to the target. Spatially, the masks were presented either overlapping or surrounding the target location. In the absence of a mask, all animals could reliably discriminate orientation when stimulus durations were 16 ms or longer. In the presence of a mask, discrimination performance was impaired, but did not systematically vary with SOA as is typical of visual masking. In humans performing a similar task, we found visual masking impaired perception of the target at short SOAs regardless of the spatial or temporal configuration of stimuli. Our findings indicate that visual masking may be difficult to observe in rats as the stimulus parameters necessary to quantify masking will make the task so difficult that it prevents robust measurement of psychophysical performance. Thus, our results suggest that rats may not be an ideal model to investigate the effects of visual masking on perception.

On Sensory Eye Dominance Revealed by Binocular Integrative and Binocular Competitive Stimuli.

PurposeTwo core processes underlie 3-D binocular vision. The first, a binocular combination/summation process, integrates similar feature signals from the two eye channels to form a binocular representation. The second, a binocular inhibitory process, suppresses interocular conflicting signals or falsely matched binocular representations to establish single vision. Having an intrinsic interocular imbalance within one or both processes can cause sensory eye dominance (SED), related to imbalances of combination (SEDcombo) and/or inhibition (SEDinhibition). While much has recently been revealed about SEDcombo and SEDinhibition, the relationship between them is still unknown.MethodsWe measured observers' foveal SEDcombo and SEDinhibition, respectively, with a pair of dichoptic horizontal sine wave gratings with different phases and binocular rivalry stimulus with vertical and horizontal gratings. We then measured horizontal and vertical monocular contrast thresholds using sinusoidal grating stimuli, and stereo thresholds using random-dot stereograms.ResultsThere exists a strong correlation between SEDcombo and SEDinhibition. An observer's interocular difference in contrast threshold was not always consistent with his/her SEDcombo and SEDinhihition, suggesting a partial binocular origin for the underlying imbalances. We also found stereo thresholds significantly increased with the magnitudes of SEDcombo, as well as with the magnitude of SEDinhibition.ConclusionsOur findings suggest a common origin for interocular imbalance in the two different binocular processes and that both types of sensory eye dominance are significant factors in impeding stereopsis.

Psychophysical evaluation of contrast sensitivity using Gabor patches in tobacco addiction

This study, an extension of Fernandes et al. (2017), provided consistent contrast sensitivity function (CSF) measurements in a large sample. CSF was assessed for luminance stimuli in different 48 chronic smokers and 50 healthy nonsmokers. Stimuli for the CSF were Gabor patches with spatial frequencies of .2, 2.5, 5.0, 10.0, and 20.0 cycles per degree (cpd). The use of Gabor patches minimizes uncertainty in spatial position and detection of frequencies. The Gabor patches consisted of vertical gratings that were multiplied by a two-dimensional spatial Gaussian envelope. All of the groups were matched for gender and level of education. All of the participants were free from any neurological disorder, cardiovascular disease, and identifiable ocular disease, and they had normal or corrected-to-normal visual acuity. No abnormalities were detected on the fundoscopic examination or optical coherence tomographic examination. The smoker group had a lower CSF compared with healthy nonsmokers at all spatial frequencies. These results indicate that cigarette smoking or chronic exposure to its constituent compounds affects early-stage visual discrimination, suggesting the existence of deficits in early visual spatial processing in smokers.

Characteristics of Visuo-Spatial Information Processing in Children with Autism Spectrum Disorder

Although atypical sensory processing is a core feature of autism spectrum disorder (ASD), there is considerable heterogeneity among ASD individuals in the modality and symptoms of atypical sensory processing. The present study examined visual processing of children with ASD, focusing on the complexity and orientation of visual information. Age- and -IQ-matched Korean children (14 ASD and 14 typically-developing (TD) children) received an orientation discrimination task involving static spatial gratings varied in complexity (simple versus complex) and orientation (horizontal versus vertical). The results revealed that ASD children had difficulty perceiving complex information regardless of orientation, whereas TD children had more difficulty with vertical gratings than horizontal gratings. Thus, group-level differences between ASD and TD children appeared greater when gratings were presented horizontally. Unlike ASD adult literature, however, ASD children did not show superior performance on simple gratings. Our findings on typical and atypical processing of ASD children have implications for both understanding the characteristics of ASD children and developing diagnostic tools for ASD.

Visual Outcomes and Higher Order Aberrations Following LASIK on Eyes with Low Myopia and Astigmatism.

Background:Laser-Assisted in situ Keratomileusis (LASIK) can induce corneal aberrations that can impact vision and patient satisfaction. Recent developments in laser technologies have helped minimise these aberrations.Objective:To assess the quality of vision and change in Higher-Order Aberrations (HOAs) following wavefront-optimized LASIK in low-myopic astigmatic patients.Methods:LASIK was performed on a total of 76 eyes in patients with myopia <4.0 D and cylinder <2.0 D using the WaveLight® EX500 excimer and FS200 femtosecond laser platform. Visual acuity, contrast sensitivity and HOAs were measured at 1 and 3 months postoperatively and compared to preoperative values. Subjective quality of vision was assessed pre- and postoperatively using a VF14 questionnaire.Results:Mean postoperative Spherical Equivalent (SE) was -0.09 ± 0.26 µm with 95% of patients within ± 0.5 D of attempted SE. Postoperative uncorrected distance visual acuity was 20/20 or better for 96% of patients. Contrast sensitivity increased against horizontal and vertical gratings at all spatial frequencies except for vertical gratings at 18 cycles/degree. Spherical aberration and total HOA increased by 0.085 µm and 0.13 µm respectively. The mean VF14 score increased from 89.2 ± 16.7% to 99 ± 1.4% postoperatively.Conclusion:LASIK performed using the WaveLight® EX500 excimer and WaveLight® FS200 laser platform provided improved contrast sensitivity and visual acuity with minimal introduction of HOAs, making it a suitable platform for low myopic astigmatic patients.

S9-3. Associative learning between orientation and color created by decoded fMRI neurofeedback

One of the promising techniques to unravel the neural causes of human visual perception and behavior is an fMRI decoded neurofeedback (DecNef) (Shibata et al., Science, 2011), which can non-invasively induce neural activities corresponding to specific information (e.g. color and motion). In the first study (Amano et al., Current Biology, 2016), subjects implicitly learned to induce the neural activity pattern in V1/V2 corresponding to red color during the presentation of an achromatic vertical grating via DecNef training. After the training, an achromatic vertical grating was perceived to be reddish, indicating the creation of orientation-specific color perception by manipulating V1/V2 activities. In the second study (Koizumi et al., Nature Human Behaviour, 2016), we could reduce fear towards a fearconditioned stimulus by pairing rewards with the activation patterns in V1/V2 representing the fear-conditioned stimulus, while participants remain unaware of the content and purpose of the procedure. This procedure may be an initial step towards novel treatments for fear-related disorders such as phobia and PTSD, via unconscious processing.