To reduce the errors caused by the rigid body hypothesis in the aerodynamics-structure coupling calculation and improve the structural performance, an optimum structure design with the consideration of the fluid-structure interaction are performed for the H-type vertical axis wind turbine (VAWT) blade. Based on the ANSYS Workbench platform, the geometric model, computational domain and grids of the wind wheel are constructed, the turbulence model, boundary conditions and composite material layers are set up, and the fluid and solid domains are solved in a coupled way. The single-objective structural optimization model in which the thicknesses of glass clothes, foam and gel coat, and the positions of two webs are taken as design variables is solved using the response surface optimization method to minimize the wind wheel mass. The frequencies and vibration modes of original and optimized blades with and without pre-stress and the transient characteristics of wind wheels in different wind speeds are investigated. The results indicate that after the blade optimization, the first-order frequency and critical speed become larger and other frequencies reduce for the static, single pre-stress and multiple pre-stresses states, and the maximum displacement, stress and strain of the wind wheel decrease under rated and extreme wind speeds, confirming significant performance improvements. The research provides useful guidance for the integrated design of structure and aerodynamics of wind turbine blades.