Vera Cream Research Articles

The Difference in the Effectiveness of Removing the Modern Super Ring Circumcision Device with Olive Drops and Aloe Vera Ointment Treatment

Background: Circumcision using the Super Ring method requires removing the ring after the wound is dry by treating used the principle of moisture. Purpose: The aim of this study was to determine the difference in the effectiveness of removing the Modern Super Ring Circumcision Device with Olive Drops and Aloe vera Ointment treatment. Method: The research design used Pre-Experimental with a post test only approach, used Accidental Sampling with a research sample of 32 respondents and tested using the Mann Whitney test. The majority of 14 respondents (87.4%) removed the circumcision ring with aloe vera ointment treatment in less than 10 days, while the majority of 15 respondents (93.7%) received circumcision ring removal with olive drops in more than 10 days. Results: The results of the Mann Whitney Test obtained a p value of 0.000, indicating that there was a significant difference, aloe vera ointment showed that the average time required to remove the Circumcision Ring was faster than olive drops. Conclusion: Aloe vera ointment made the wound environment more moist, thereby speeding up the wound healing process.

Topical Pistacia vera L. Seed Oil Preparation and Its Effects on Knee Osteoarthritis Through a Randomized Double-blind Controlled Clinical Trial

Background: Osteoarthritis (OA) is a degenerative joint disease that globally affects the elderly, leading to pain and disability. Herbal medications and alternative therapies have demonstrated positive effects on arthritis management. Pistacia vera has traditionally been used for inflammatory conditions and has also shown antinociceptive effects. Objectives: Given the limited available scientific evidence, our randomized controlled trial aimed to assess the potential protective role of topical P. vera seed oil preparation in patients with knee OA. Methods: A total of 89 patients with knee OA (n = 89) were randomly allocated into three groups: Placebo, piroxicam, and P. vera. The topical formulations were administered twice daily over a period of three months. Pain level, patient health status, and performance were evaluated using the visual analog scale (VAS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Statistical analysis was performed using SPSS software. Results: The application of P. vera ointment demonstrated pain reduction in patients, as indicated by VAS and WOMAC assessments. Additionally, WOMAC scores showed that P. vera ointment alleviated motion stiffness and improved activity difficulties in patients (P < 0.001). In certain parameters, the topical application of P. vera showed greater effectiveness in treating knee OA than piroxicam (P < 0.05). Conclusions: Pistacia vera ointment shows promise as a potential therapeutic option for osteoarthritis, effectively addressing the detrimental effects of the disease. Further experimental and clinical studies are warranted to elucidate its efficacy and safety profile.

Biochemical and histopathological changes related to the topical application of Aloe vera ointment for canine pyoderma.

Background and Aim:Pyoderma is common in dogs, and its treatment requires a novel medication rather than antibiotic therapy. This study aimed to determine the biochemical and histopathological changes associated with the topical application of Aloe vera 20% and 40% ointments, compared with gentamicin 0.1% ointment, in dogs suffering from Staphylococcus aureus pyoderma.Materials and Methods:Serum and skin samples were collected from a negative control group before inducing pyoderma and from other subdivided groups on the 3rd, 7th, 10th, and 14th days post-inoculation for biochemical and histopathology examination.Results:Serum aspartate aminotransferase, alanine aminotransferase (ALT), urea, and creatinine concentrations were higher in the positive control dogs on the 3rd day without treatment (DWT) compared with the negative control dogs (p<0.05). Compared with the healthy control dogs, serum zinc concentrations were lower in the positive control group on the 3rd, 7th, and 10th DWT and in dogs treated with A. vera 20% and gentamicin 0.1% ointments on the 3rd and 7th days post-treatment (p<0.05). Grossly, skin had erythema, pruritus, and pus-filled pustules of the untreated group. Microscopically, skin showed epidermal necrosis and edema, dermal collagen necrosis, and severe neutrophilic infiltration.Conclusion:Compared with A. vera 20% and gentamicin 0.1% ointments, the topical application of A. vera 40% ointment-induced quicker skin healing and decreased the inflammatory changes caused by S. aureus inoculation, based on biochemical and histopathological changes reflective of its curative efficiency. A. vera 40% ointment may be a suitable alternative to antibiotics for the treatment of staphylococcal pyoderma in dogs.

Comparing the Effects of Aloe Vera Ointment with Routine Treatment on the Severity of Diaper Dermatitis: A Randomized Controlled Double-Blinded Clinical Trial

Background: Diaper dermatitis (DD) is a prevalent skin disease in children, which causes child discomfort and parental concern. This study aimed to compare the effects of aloe vera ointment with routine treatment on the severity of DD in hospitalized children. Materials and Methods: This double-blinded randomized clinical trial was carried out on 60 children aged less than two years admitted to Tabriz pediatric hospital in Iran from February to June 2017. Using convenience sampling method, the patients were assigned into two equal groups (n=30 in each) of intervention and control. The intervention group received routine combination treatment, whereas the control group received aloe vera ointment. The patients were examined on the first, third, and sixth days of the study. Data analysis was performed using SPSS software (version 22) and descriptive and analytical statistics. Results: The severity of DD in both groups improved on the sixth day compared to the first day. In comparison, no significant difference was observed between the two groups regarding the severity of dermatitis (P&gt;0.05). Conclusion: Herbal products cause fewer side effects than chemical products and seem to have significant pharmacological effects on the skin. Thus, aloe vera ointment appears to help treat DD and, with further studies, may emerge as a possible therapeutic option.

Prevention of acute radiation-induced Proctitis by Aloe vera: a prospective randomized, double-blind, placebo controlled clinical trial in Pelvic Cancer patients

BackgroundAcute radiation-induced proctitis (ARP) is the most common side effect following radiotherapy for malignant pelvic disease. This study evaluated the efficacy of Aloe vera ointment in prevention of ARP.MethodsForty-two patients receiving external-beam radiotherapy (RT) for pelvic malignancies were randomized to receive either Aloe vera 3% or placebo topical ointment during radiotherapy for 6 weeks. These patients were evaluated based on the severity (grade 0–4) of the following symptoms weekly: rectal bleeding, abdominal/rectal pain, diarrhea, or fecal urgency. RTOG acute toxicity criteria and psychosocial status of the patients were also recorded weekly. Lifestyle impact of the symptoms, and quantitative measurement of C-reactive protein (CRP), an indicator of systemic inflammation, were also measured.ResultsThe results of present study demonstrated a significant preventive effect for Aloe vera in occurrence of symptom index for diarrhea (p < 0.001), rectal bleeding (p < 0.001), and fecal urgency (p = 0.001). The median lifestyle score improved significantly with Aloe vera during RT (p < 0.001). Intervention patients had a significant lower burden of systemic inflammation as the values for quantitative CRP decreased significantly over 6 weeks of follow-up (p = 0.009).ConclusionThis study showed that Aloe vera topical ointment was effective in prevention of symptoms of ARP in patients undergoing RT for pelvic cancers.Trial registrationIRCT201606042027N6. Registration date: 2016-09-04.

Treatment of experimentally induced diabetic wound infected with methicillin-resistant Staphylococcus aureus using Aloe vera, Apium graveolens, and Sauropus androgynus extracts in rats

Background and Aim: One of the complications of diabetes mellitus is diabetic ulcer. Diabetic ulcer is commonly infected by infectious agents, especially methicillin-resistant Staphylococcus aureus (MRSA). This study aimed to evaluate the potential effects of alcoholic extracts of Aloe vera, Apium graveolens, and Sauropus androgynus on promoting wound healing in a diabetic wound infected with MRSA. Materials and Methods: A total of 60 male Sprague-Dawley rats (6 months old, weighing 250-300 g) were injected with 65 mg/kg body weight of streptozotocin to induce diabetes. On day 7, the backs of the rats were shaved, and two circular wounds (4 mm in diameter) were created on their back, which were infected with MRSA. The rats were divided into six groups: Group I = control, Group II = treated with cream base without extract, Group III = treated with 2% A. vera cream, Group IV = treated with 2% A. graveolens cream, Group V = treated with 2% S. androgynus cream, and Group VI = treated with 2% A. vera + 2% A. graveolens + 2% S. androgynus cream. The wounds were treated twice a day for 14 days. The data were collected on days 7 and 14. Results: The results showed that all three herbal extracts and their combination decreased wound area and percentage of the wound, increased tensile strength of skin, collagen deposition, vascular endothelial growth factor expression, and skin thickness, and depressed the C-reactive protein profile and cyclooxygenase-2 expression. Conclusion: A. vera, A. graveolens, and S. androgynus creams can be used as herbal therapies against diabetic wounds infected with MRSA, both as a single and combination treatment.

Aloe Vera Ointment Application and Skeletal Muscle Recovery

Aloe Vera Ointment Application and Skeletal Muscle Recovery

Effects of Aloe Vera Gel versus Chamomile Ointment on extent of Diaper Dermatitis in Children: A Double-Blind Randomized Controlled Trial

Background Diaper dermatitis is one of the most prevalent skin disorders in neonates and children. The purpose of this study was to compare the effects of Aloe Vera and chamomile ointment on the degree of diaper dermatitis in children. Materials and Methods In this double-blinded randomized clinical trial, 90 children below two years of age, who had diaper dermatitis and were hospitalized in the Tabriz Pediatric Hospital, Tabriz city- Iran, were included in the study using random sampling. The children were divided into three equal groups, with one group receiving routine treatments and the other two receiving chamomile and Aloe Vera ointment three times a day. The samples were examined on the first, third, and sixth day of the study using a diaper rash five-point scale. The data were analyzed by descriptive and analytical tests in SPSS software version 22.0. Results Baseline criteria such as age, gender, and education of mothers were similar in all the groups (P>0.05). Moreover, the dermatitis extent recovery was achieved over time (P 0.05). Conclusion There was no difference between the Aloe Vera, chamomile, and routine treatments in dermatitis extent recovery.

Studying the Effect of Aloe Vera Ointment on Wound Healing of CABG Surgery in Diabetic Patients

Background and Purpose: one of morbidities of diabetes is delay in wound healing. Among treatment common procedures in diabetic patients with coronary artery bypass graft. Therefore, delay in CABG wound healing is one of common problems of diabetic patients. Aloe vera plant contains collagen which heightens the tissue granules and contributes in wound healing process with its anti-inflammatory properties. Thus, the researcher tries to examine the effect of Aloe vera on wound healing. Methodology: the study was random clinical trial with intervention and control groups. 60 diabetic patients who attended to Imam Ali Hospital, Kermanshah for CABG surgery have been assigned to two 30-person groups as intervention and control groups. From second day after surgery, after putting out the sternum area chip pipe of intervention group patients, after washing with betadine they were bandaged by 2% aloe vera ointment which was made by Karaj academic Jihad organization medicinal herbs research center in a daily basis. In control group only daily washing with betadine and bandage has been done. This has been conducted till 14 days after surgery. Wound healing in days 7, 4 and 14 after surgery has been evaluated by Bates Jenson wound healing scale. One used SPSS version 16 for analyzing the data. In this study, for describing the samples, one used descriptive statistical methods including tables of frequency distribution, determining average, SD and when it comes to study objectives and hypothesis, determining the homogeneity of samples one uses Chi two and Mann Whitman non-parametric test. Findings: mean and SD of total score of wound healing of two groups is calculated at day 4 after intervention by independent Mann Whitman test that P>0,5 therefore two groups had no significant different in wound healing, in day 7 after intervention the mean and SD of wound healing score had significant different based on Mann Whitman test P<0.001 at day 14 after intervention based on Mann Whitman test, there was a significant different between two groups in terms of wound healing p<0.001. Conclusion: 2% Aloe vera ointment can speed up the healing of wound of CABG surgery in diabetic patients after at least one week use.

Evaluation of the Effect of Aloe Vera Ointment with Chamomile Ointment on Severity of Children’s Diaper Dermatitis : A Randomized, Double-Blind Clinical Trial

Introduction: Diaper dermatitis is an inflammation of the skin under the diapers of children, and is relatively common. The disease is seen in children and adolescents with a degree of urinary incontinence. The aim of this study is to replace uncomplicated herbal medicines in the treatment of this disease instead of chemical drugs. Materials and Methods: This is a randomized, double-blind, clinical trial that was performed on 90 children under 2 years of age who were referred to the Pediatric Department of Tabriz Pediatric Hospital and who used diapers. The children were randomly divided into three groups of 30, and formed a routine group and two other groups, with routine ointment and chamomile and Aloe Vera Ointment. Sampling was performed on the first, third and sixth days of the study using a five point scale. Data were analyzed using SPSS software (version 22) and descriptive and analytical statistics. Results: According to the statistical results, the severity of dermatitis in all three groups improved during the study on the sixth day compared to the first day, but there was no significant difference in the severity of diaper dermatitis between the three groups during the study period. (P> 0.05) Conclusion: Regarding the treatment process in all three groups and having positive results in the treatment of dermatitis, the three groups of drugs were effective in treatment, but they were not superior to each other. But due to the lower side effects of herbal medicine, its use is recommended to treat this condition. Key words: Aloe vera ointment, chamomile ointment, diaper dermatitis

Effect ofAloe veraapplication on the content and molecular arrangement of glycosaminoglycans during calcaneal tendon healing

Although several treatments for tendon lesions have been proposed, successful tendon repair remains a great challenge for orthopedics, especially considering the high incidence of re-rupture of injured tendons. Our aim was to evaluate the pharmacological potential of Aloe vera on the content and arrangement of glycosaminoglycans (GAGs) during tendon healing, which was based on the effectiveness of A. vera on collagen organization previously observed by our group. In rats, a partial calcaneal tendon transection was performed with subsequent topical A. vera application at the injury site. The tendons were treated with A. vera ointment for 7 days and excised on the 7(th) , 14(th) , or 21(st) day post-surgery. Control rats received ointment without A. vera. A higher content of GAGs and a lower amount of dermatan sulfate were detected in the A. vera-treated group on the 14(th) day compared with the control. Also at 14 days post-surgery, a lower dichroic ratio in toluidine blue stained sections was observed in A. vera-treated tendons compared with the control. No differences were observed in the chondroitin-6-sulfate and TGF-β1 levels between the groups, and higher amount of non-collagenous proteins was detected in the A. vera-treated group on the 21(st) day, compared with the control group. No differences were observed in the number of fibroblasts, inflammatory cells and blood vessels between the groups. The application of A. vera during tendon healing modified the arrangement of GAGs and increased the content of GAGs and non-collagenous proteins.

EXPLORATION OF HEALING PROMOTING POTENTIALS OF LEAVES OF &lt;i&gt;MORUS ALBA&lt;/i&gt; L. IN ALBINO RATS

To establish the wound healing activity of aqueous and ethanolic extract of roots of Morus alba. Two models were performed to evaluate the wound healing activity i.e., Incision and Excision model. In incision model the parameter which was carried out was breaking strength of wounded skin. In excision model percentage wound contraction and period of epithelialization was established for both the extracts. Reference standard drug was Aloe vera ointment for comparison with other groups. From the observation in both the models, Aq. extract of Morus alba was found to have greater wound healing activity in terms of breaking strength in incision model and percentage wound contraction, period of epithelialization was highest in excision model compared with other groups. In conclusion, our findings suggest that aq. extract of Morus alba possess better healing ability than the ethanolic extract.

Structural and biochemical alterations during the healing process of tendons treated with Aloe vera

AimsThe tendon is composed of highly organized collagen fibers that form a complex supramolecular structure. After lesions, the organization and composition of the tendon are not completely restored. Our purpose was to evaluate if the application of Aloe vera improves tendon healing, considering the effectiveness in the stimulus of collagen synthesis. Main methodsThe calcaneal tendon of male Wistar rats was partially transected with subsequent topical application of A. vera ointment at the injury. The animals were separated into groups with tendons treated with the A. vera extract for 7days and excised on the 7th, 14th and 21st days after surgery; control rats received only ointment base without plant extract. Key findingsMorphological analysis using polarization microscopy showed that the entire tendon undergoes a remodeling process, with disorganized collagen fibers by days 7 and 14 in plant-treated and non‐treated groups and with a higher birefringence in tendons of the plant-treated group on the 21st day. A higher concentration of hydroxyproline was found in plant-treated tendons on days 7 and 14 compared with their controls. Western blots showed lower amounts of type I collagen in the plant-treated group on day 14 compared with the control. MMP-9 diminished 14days after lesion and the active isoform of MMP-2 increased on day 21 in plant-treated groups. SignificanceThe present study indicates a beneficial effect of A. vera in the tissue reorganization in the transected region of the tendon 21days after injury and is supported by an increase of active MMP-2.

Physiopathology of the repair process of lesions of Achilles tendon

The tendon is composed of highly organized collagen fibers that form a complex supramolecular structure. After lesions, the organization and composition of the tendon are not completely restored. Our purpose was to evaluate if the application of Aloe vera improves tendon healing, considering the effectiveness in the stimulus of collagen synthesis.The calcaneal tendon of male Wistar rats was partially transected with subsequent topical application of A. vera ointment at the injury. The animals were separated into groups with tendons treated with the A. vera extract for 7 days and excised on the 7th, 14th and 21st days after surgery; control rats received only ointment base without plant extract.Morphological analysis using polarization microscopy showed that the entire tendon undergoes a remodeling process, with disorganized collagen fibers by days 7 and 14 in plant-treated and non‐treated groups and with a higher birefringence in tendons of the plant-treated group on the 21st day. A higher concentration of hydroxyproline was found in plant-treated tendons on days 7 and 14 compared with their controls. Western blots showed lower amounts of type I collagen in the plant-treated group on day 14 compared with the control. MMP-9 diminished 14 days after lesion and the active isoform of MMP-2 increased on day 21 in plant-treated groups.The present study indicates a beneficial effect of A. vera in the tissue reorganization in the transected region of the tendon 21 days after injury and is supported by an increase of active MMP-2.