Abstract
To establish the wound healing activity of aqueous and ethanolic extract of roots of Morus alba. Two models were performed to evaluate the wound healing activity i.e., Incision and Excision model. In incision model the parameter which was carried out was breaking strength of wounded skin. In excision model percentage wound contraction and period of epithelialization was established for both the extracts. Reference standard drug was Aloe vera ointment for comparison with other groups. From the observation in both the models, Aq. extract of Morus alba was found to have greater wound healing activity in terms of breaking strength in incision model and percentage wound contraction, period of epithelialization was highest in excision model compared with other groups. In conclusion, our findings suggest that aq. extract of Morus alba possess better healing ability than the ethanolic extract.
Highlights
The wound repair process has three orderly but temporally overlaid stages: Inflammation, cell proliferation and tissue regeneration (Murti et al, 2011a)
In excision model percentage wound contraction and period of epithelialization was established for both the extracts
From the observation in both the models, Aq. extract of Morus alba was found to have greater wound healing activity in terms of breaking strength in incision model and percentage wound contraction, period of epithelialization was highest in excision model compared with other groups
Summary
The wound repair process has three orderly but temporally overlaid stages: Inflammation, cell proliferation and tissue regeneration (Murti et al, 2011a). Wound healing is a process which is fundamentally a connective tissue response. There are several reports stating that the extracts of several plants, used for wound healing properties (Suntar et al, healing activity (Murti et al, 2011b). Phytochemical reports on M. alba L. indicates that the plant contains flavonoids, tannins, triterpenes, anthocyanins, anthroquinones, phytosterols, sitosterols, benzofuran derivatives, morusimic acid, oleanolic acid, alkoloids, steroids, saponins and phenolic compounds (El-Beshbishy et al, 2005; Kusano et al, 2002). No major investigative reports were found pertaining to its wound healing activity of roots; we undertook the present study to determine the healing promoting potential of M. alba leaves by using different animal models for wound healing based on exploratory behavior
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