It is the key and difficult point to ensure the safety of tunnel construction by ventilation in high gas tunnel construction in high altitude and cold area. Taking ning-chan high gas tunnel as the research object, the ventilation of the tunnel is calculated, the ventilation parameters are optimized, the ventilation equipment is selected according to the calculation results, the location of the ventilation equipment is optimized, and the reasonable construction ventilation scheme is determined. The results show that through the design of the above ventilation scheme and the control of the site, it can not only ensure the ventilation demand of the super long and high gas tunnel construction in the high cold and high altitude area, but also ensure the tunnel construction in winter, and effectively save the construction ventilation cost.