The current analysis signifies the Casson nanofluid stream with inclined magnetohydrodynamics, viscous dissipation, joule heating, thermal radiation, particle shape factor effects over a moving flat horizontal surface with entropy analysis. This study presents a novel idea regarding the implementation of Tiwari and Das model on Casson fluid model by considering ethylene glycol as a base fluid. Tiwari and Das model considers nanoparticles volume fraction for heat transfer enhancement instead of the Buongiorno model which heavily relies on thermophoresis and Brownian diffusion effects for heat transfer analysis. The velocity slip and convective slip boundary conditions have been employed at the surface of the sheet. By utilizing the suitable transformations, the modeled PDEs (partial-differential equations) are renewed in ODEs (ordinary-differential equations) and treated these equations numerically with the help of classical Keller box method. Two different classes of nanofluids, Copper-Ethylene Glycol () and Molybdenum Disulfide-Ethylene Glycol () have been taken into considering for our analysis. The behaviour of surface drag coefficient and Nusselt number for the varied values of various sundry parameters is designed via tables. Our findings show that an increase in the Reynolds and Brinkman numbers increased the overall entropy of the system.