To prevent and control the thermal runaway (TR) and its propagation of lithium-ion batteries (LIBs) is a key problem for its sustainable development and wide application. However, there is still a gap in the research on the characteristics of two-phase flow of nitrogen(N2) and water mist (NWM) controlling TR and its propagation in different longitudinal ventilation environments. In this study, the influence of wind velocity on 0.5 MPa NWM to control TR and its propagation characteristic parameters of LIB module was studied experimentally. The results show that with the increase of wind velocities, the opening time of the safety valve and TR trigger temperature of the LIB module gradually increased. At the same wind velocity, TR trigger temperature of cell 1 to cell 5 was successively reduced after 0.5 MPa NWM was applied. The cooling and asphyxiation effect of 0.5 MPa NWM is the best in natural ventilation environment, but the suppression effect of 0.5 MPa NWM on TR propagation of the LIB module is weakened under the influence of forced ventilation. However, different wind velocities have little effect on TR trigger temperature of the blocked LIB module. At the same time, a quasi-steady state thermal equilibrium of the NWM in a ventilation environment was established for the LIB module, and the influence of the coupling effect of different longitudinal ventilation environments and 0.5 MPa NWM on TR propagation characteristic parameters of the LIB module and the heat transfer mechanism in the thermal runaway propagation process were compared under the two conditions of within or without battery case. It is found that the convection effect of the wind plays a leading role in the heat dissipation of the blocked LIB module when the wind velocity is less than 4.5 m/s. The heat conduction of the battery case plays a leading role when the wind velocity is greater than 4.5 m/s. Moreover, in any ventilation environments, TR propagation time of the blocked LIB module is smaller than that of the unblocked LIB module. Under the same wind velocity, TR trigger temperature of the blocked LIB module and the maximum temperature of each cell are higher than that without battery case. This work provides a new perspective for controlling TR propagation of the LIBs. At the same time, it can provide theoretical guidance for ensuring process safety and firefighters to fight LIB fire accidents.