Fatigue fracture is the main failure form of mining drill pipe joints, which directly leads to the occurrence of drill pipe drop accidents. Based on the principle of engineering bionics, the spine structure and kinematic behavior characteristics of cheetah were studied; the bionic design and trial production of drill pipe joints were carried out. For the bionic drill pipe joint, it separates the torsion transmission function from the connection function, and when the torsion transmission function of the joint fails, the connection function is still effective, so as to achieve the effect of “breaking the bones and connecting the ribs.” The mechanical and flow field properties of the bionic drill pipe joint were analyzed. Mechanical test results showed that, for the bionic drill pipe joint, the average tensile capacity was 555.48 kN and the average torsion capacity was 8914.13 N·m, which met the mechanical performance requirements. The flow field numerical simulation results showed that, when the drilling fluid velocity field and pressure field were stable and change evenly, there is no risk of leakage. The study results can provide a new research idea for the research and development of mine drill pipe joint with long life and antidropping function.