PurposeWith possible uses in engineering and industrial processes, this work aims to further our knowledge of fluid dynamics and heat transfer in complicated flow configurations. This study looks at how Al2O3−Cu/H2O hybrid nanofluids move across a nonlinear radiative 3D unsteady surface. It tries to figure out what happens when the Hall current, variable viscosity, viscous dissipation, velocity and thermal slip conditions work together. The goal of this analysis is to provide insight into the system's thermodynamic behavior and the ways in which these elements affect the flow's entropy generation. MethodologyThe controlling system is converted into nonlinear nondimensional partial differential equations (PDEs) by applying suitable non-similar transformations. In this work, the governing equations are simulated using the local non-similarity (LNS) approach up to the second truncation level using the numerical technique bvp4c in MATLAB. FindingsThe temperature, velocity, entropy production, skin friction in both directions, and Nusselt number profiles of the nanofluid and hybrid nanofluid are detailed in many figures. The tabular form contains the results of computing the local Nusselt number for linear, nonlinear, and radiation-free scenarios. The velocity profiles in both directions and the temperature profile grow as the rotation parameter and nanoparticle volume fraction parameter increase. Conversely, the velocity profiles drop when the variable viscosity parameter falls, while the temperature profile increases. When the unsteadiness parameter A is set to 0.5 and the nanoparticle volume fraction is 1%, hybrid nanofluid has 4.26% lower x-direction skin friction than nanofluid and 3.62% greater y-direction friction. When the unsteadiness parameter A = 0.5 and the nanoparticle volume percentage is 1%, a hybrid nanofluid has a 2.77% higher Nusselt number than a nanofluid. The generation of entropy was also enhanced by an increase in the volume fraction of nanoparticles, radiation, temperature ratio, and Brinkman number. We evaluate and contrast the results of this study with those of earlier research.