Vegetative Disorders Research Articles

Research of the personal characteristics of patients with vegetative disorders in relation to clinical and instrumental indicators

The aim of the research was to study the personality traits of patients with vegetative disorders (VD) and the identification of their psychosomatic relationships with heart rate variability (HRV) and with a clinical degree of severity of vegetative manifestations.The military personnel of Petrozavodsk were examined: the main group (MG) — 104 people with VD (average age 36,8±7,7 years, gender index 1:1); control group (СG) — 30 healthy individuals (average age 36,1±5,5 years; gender index 1:1; p=0,761).We used: «A questionnaire to identify signs of vegetative changes» (Vane A. M., 2003); cardiointervalography with an assessment of integrative indicators (standard deviation of RR — intervals (SDNN, ms) and total power of the spectrum (TR, ms2)). Personality traits were examined using the «Big Five» test (The Big Five Inventory–2 Short Form (BFI–2–S)). Statistical processing of experimental data was carried out in Excel 14.0 environment using Statistica 6.0 software packages. It was revealed that in patients with VD, compared with healthy ones, there is a moderate vegetative imbalance (36,63±10,50 / 2,67±1,96 points according to the A. M. Vane questionnaire); and a decrease in the level of vegetative regulation (with a predominance of sympathetic) with a decrease in adaptive capabilities (TP 1512,69±1005,38 ms2 and 6548,80±3898,95 ms2; SDNN 38,34±13,27 ms and 80,17±23,59 ms in MG and СG, respectively; p<0,05).The results of BFI–2–S indicated that patients with VD have an increased level of neuroticism against the background of a weakening of such personal qualities as: extraversion, benevolence, good faith, openness to experience. Neuroticism is a characteristic personality trait that, through a system of psychosomatic relationships, exacerbates the clinical and neurological manifestations of the disease. It directly correlates with the severity of vegetative imbalance (according to the A. M. Vane questionnaire; R = 0,66), and vice versa — with heart rate variability (R = — 0,56 for SPNN; R = — 0,53 for TP). The results of the study make it possible to optimize personalized strategies for the medical and psychological rehabilitation of people with VD.

Специфика психических состояний осужденных женщин, содержащихся в местах лишения свободы с малолетними детьми

Introduction. The aim of the empirical study was to research the mental states of convicted women with young children. The study sample consisted of 153 convicted women with young children serving their sentences in a correctional institution. The study was conducted on the basis of the State Department of the Federal Penitentiary Service of Russia for the Kemerovo Region, the Federal Penitentiary Service of Russia for the Moscow Region, the Federal Penitentiary Service of Russia for the Vladimir Region, the Federal Penitentiary Service of Russia for the Republic of Mordovia. The scientific problem is to study the mental states of convicted women with young children. Research methods and techniques. The following set of methods was used to study mental states: ‘16-factor personality questionnaire - 16 PF’, form C (R. Kettell), “Depression scale” (A. Beck), clinical questionnaire for identification and assessment of neurotic states (K. K. Yakhin, D. M. Mendelevich), methodology for determining the dominant mental state “Dominant state” (L. V. Kulikov), questionnaire for studying the level of aggression (A. Bass and A. Darkey). The results of the conducted research were the identification of mental states of convicted women in prison with young children. It was established that negative mental states (tension, emotional instability, frustration, anxiety, irritation, depression, anxiety) prevail among these women.They are expressed fatigue, hysteria, vegetative disorders, which are manifested in unpleasant or painful somatic sensations. A high level of aggression and hostility has been diagnosed. The revealed negative mental states need timely psychological correction.

Chronic pelvic pain syndrome in women of reproductive age: An observational cohort clinical ultrasound study

Background. The annual number of new cases of chronic pelvic pain syndrome in women of reproductive age is increasing worldwide. The high prevalence of this condition among the able-bodied female population leads to higher state expenditures on the treatment of this category of patients. New methods of diagnosis and early prophylaxis contribute to reducing economic burden associated with chronic pelvic pain syndrome in women and improving health of the female population as a fundamental demographic factor.Objectives. To determine somatic, obstetric-gynecological, anatomical, and psycho-emotional predictors of chronic pelvic pain syndrome.Methods. An observational cohort clinical and ultrasound study involved 60 patients of reproductive age. The study was conducted on the basis of the clinic for women, Voronezh City Outpatient Clinic No. 1 — clinical base of the Department of Obstetrics and Gynecology No. 2, Voronezh State Medical University named after N. N. Burdenko, Russia. According to clinical and laboratory data, the participants were divided into 2 groups. Group 1 (n = 30) included women of reproductive age without clinical manifestations of chronic pelvic pain syndrome; Group 2 (n = 30) enrolled women of reproductive age clinically diagnosed with chronic pelvic pain.Results. The mean age of the study participants in the main group comprised 27.4 ± 6.30 and 26.3 ± 7.25 years in the control group, p > 0.05. Diseases of gastrointestinal tract, endocrine, cardiovascular, musculoskeletal and urinary systems, as well as neurocirculatory and vegetative disorders prevailed in the structure of somatic pathology in the main group, p < 0.001. Analysis of obstetric and gynecologic anamnesis revealed no statistically significant differences in the incidence of gynecologic pathology in the study groups. However, according to the detailed analysis of the delivery history of the participants, 23 patients of the main group (76 %) and 3 patients (6.6 %) of the control group underwent episiotomy during labor, p < 0.001. The evaluation of the comparison groups in terms of pain component in myofascial syndrome involved the pain rating index, number of selected descriptors, sensory index of the selected descriptors, emotional index of the selected descriptors, and pain intensity. Statistically significant differences were revealed for all of the above indicators, thereby confirming a reliable picture of pathopsychological changes in the compared groups of women. The analysis of the ultrasound parameters of topographic and anatomical relationships demonstrated the relevant change in the following parameters: urethral length, diameter of the external urethral sphincter, angle between the external urethra and the body of the bladder, direct and transverse dimensions of the levator hiatus in the studied groups under the muscle tension.Conclusion. An issue of early diagnosis and prophylaxis of chronic pelvic pain syndrome in women of reproductive age remains urgent and requires interdisciplinary participation of medical specialists. The development of new approaches to ultrasound evaluation of pelvic floor will increase the effectiveness of therapeutic and prophylactic measures and reduce the economic burden of this nosology in the morbidity structure of the able-bodied female population.

Anxiety and depressive personality disorders in the modern world

The study's significance lies in the multitude of challenges facing individuals today, such as the COVID-19 pandemic, military conflicts like the war in Ukraine, and the escalating rates of cancer morbidity and mortality. These factors contribute to the onset of anxiety and depressive disorders, disrupting various aspects of individuals' mental functioning and social interactions. Addressing these disorders effectively necessitates a comprehensive approach, combining pharmacological interventions with psychotherapeutic strategies under the guidance of specialized professionals. In this regard, the study is aimed at identifying aspects and features of the development of psychological problems and personality disorders in the modern world filled with various stressors. The leading methods of studying this problem are analysis, synthesis, induction, deduction, comparison, experiment and systematisation of approaches that will help determine a wide range of mental disorders. Theoretical methods were used to analyze the literature and summarize theoretical material on anxiety and depressive disorders. Diagnostic methods were used to assess the psychological state of the study population. The study examines significant clinical syndromes and vegetative disorders that disrupt normal lifestyle, hinder daily activities, and impede professional growth. It evaluates the roles of psychologists, psychiatrists, and social workers in assisting individuals with anxiety disorders. It outlines preventive measures for anxiety and depression, while also delving into various types of anxiety disorders. The research proposes diverse methods to prevent emotional anxiety and instability. It underscores the importance of devising novel strategies for diagnosis and therapy, emphasizing a comprehensive approach involving psychotherapeutic support, medical intervention, and adaptive behavioral techniques. The findings of the study hold both practical and theoretical significance for professionals in psychology, psychiatry, psychoanalysis, and sociology who provide support for individuals with anxiety and depressive disorders. Furthermore, the insights provided may be pertinent to researchers and scholars investigating the psychological well-being of contemporary society amidst adverse external circumstances.

Невротические состояния женщин и особенности отношения к новорожденному в ситуации «отягощенного» материнства

<p style="text-align: justify;"><strong>Objectives. </strong>The growing number of children with mental health needs leads to an increase in the need for research on this issue. The subjective phenomenon of "burdened" motherhood is considered as an environmental risk factor for child mental health disorders. The article presents the results that allow us to consider the attitude to the newborn and the pronounced neurotic states of the mother among the unfavorable factors in the formation of the "mother-child" dyad.</p> <p style="text-align: justify;"><strong>Methods</strong>. A total of 228 women participated in the study. Comparison groups of 173 respondents were formed. The unifying criterion of the groups is the special conditions for the formation of the "mother-child" system in the situation of "burdened" motherhood. 55 women with preserved reproductive function, whose pregnancy ended with the birth of a healthy child, are classified as "conditional norm". The Pregnant Woman's Attitude Test by I.V. Dobryakov, the Clinical Questionnaire of Neurotic States by K.K. Yakhin and D.M. Mendelevich, the method of semi-structured interview, the methods of statistical processing of empirical data Mann-Whitney U-test and Spearman's rank correlation coefficient were used.</p> <p style="text-align: justify;"><strong>Results. </strong>Women in a situation of "burdened" motherhood are more likely to transmit an anxious attitude towards the newborn (U = 210.0; p = 0.004235). Positive correlations between anxious and depressive attitudes towards the newborn and indicators on the asthenia scale of the Neurotic States Questionnaire (r = 0.39; <0.05) are described. Empirical data have confirmed the presence of pronounced neurotic states in women in the situation of "burdened" motherhood on the following scales: "anxiety", "hysterical type of reaction", "obsessive-phobic disorders" and "vegetative disorders".</p> <p style="text-align: justify;"><strong>Conclusions. </strong>The obtained data indicate that the features of the attitude towards the newborn and the level of severity of neurotic states in women in the situation of "burdened" motherhood, can be considered among the risk factors for mental health disorders in infancy and young age.</p>

Vegetative disorders in anxiety disorder: A review

Vegetative disorders in anxiety disorder: A review

Research of the emotional state of young tutors working with children with autism spectrum disorders

Introduction. The work of specialists involved in psychological, medical and pedagogical support of children with autism spectrum disorders (ASD) has an impact on the emotional state of educators, often causing professional burnout. It is widely discussed in the literature among educators with a long work experience. The authors consider it relevant to isolate and investigate the initial symptoms of burnout. Materials and methods. The study involved 14 tutors, women aged 24 to 30 years, working in resource classes for children with ASD and 14 teachers of inclusive classes. Research methods: questionnaire survey, psychological testing. The authors used the “Methodology for diagnosing the level of emotional burnout” (Boyko, 1998), “Scale of psychological well-being” by K. Riffe in adaptation of T.D. Shevelenkova, T.P. Fesenko (2005), Clinical questionnaire for identifying neurotic states by K.K. Yakhin, D.M. Mendelevich (1998). Statistical processing was performed using IBM SPSS Statistics 26 program. The nonparametric Mann-Whitney criterion (p≤0,05) was used to compare indicators. Results. All tutors noted significant fatigue after the working day, half of them also experienced psychological discomfort, difficulties in communication, less optimistic assessment of their abilities. According to V.V. Boyko’s test, the phase of tension is formed in three tutors, it is in the stage of formation in eleven; the phase of resistance – in three, and it is in the stage of formation in nine; the phase of exhaustion – in one tutor, it is in the stage of formation in four. The most pronounced symptoms are “Dissatisfaction” and “Emotional disorientation” – in 71.4%. Eight teachers (57.1%) felt the presence of problems hindering their psychological well-being and emotional comfort. Eight out of fourteen revealed painful symptoms on the scales of vegetative disorders, neurotic depression, and anxiety. Comparison of indicators in the groups of tutors and teachers of inclusive classes showed reliable differences in many parameters (p≤0.05), but the tutors of inclusive classes also showed forming symptoms of tension and vegetative disorders. Conclusion. The results obtained in the study of tutors with less than three years experience of work with children with ASD indicated the presence or formation of their suboptimal functional state of the body, which requires timely detection and correction with the participation of psychological and medical specialists.

Санаторная реабилитация детей школьного возраста с постковидным астеническим синдромом

Aim. To study the effects of sanatory rehabilitation factors for the intensity of asthenic manifestations of post-COVID syndrome in school-aged children. Design. A non-randomized controlled study was conducted. Materials and methods. We examined 60 children aged 8 to 13 years old with asthenic manifestations of post-COVID syndrome; 20 healthy children were used as controls. Rehabilitation was organised at Svetlana health camp (a branch of the Territorial Clinical Hospital, Perm). All children shared their complaints and medical history as well as had their somatic and neurological status checked before and after rehabilitation. The degree of asthenia was determined using the Multidimensional Fatigue Scale; the functional status was evaluated using the functional status scale for post-COVID-19 patients; vegetative manifestations were recorded in a questionnaire and a pattern developed by A. M. Wein. Saliva levels of monocytic chemotactic protein-1 were determined with ELISA. Results. Children with past COVID-19 demonstrated a higher level of asthenia seen on the fatigue sub-scale — 81.22 [50.0; 100.0] points (р = 0.02 vs. controls), together with vegetative disorders; and saliva levels of monocytic chemotactic protein-1 (18.0 [12.5; 29.7] pg/mL) were higher than in controls (16.35 [11.00; 22.60] pg/mL; р = 0.012). After rehabilitation in a health camp, the intensity of asthenia decreased to 87.18 [75.0; 100.0] (р = 0.02), vegetative dysfunction improved, and functional status class changed from 1.74 [1.0; 3.0] to 0.77 [0; 1.0] (р = 0.02); saliva levels of monocytic chemotactic protein-1 increased to 23.1 [13.7; 43.7] pg/mL (p = 0.04). Quantitative changes are associated with improved clinical manifestations of post-COVID syndrome; therefore, elevated levels of this protein are a positive change. Conclusion. Post-COVID syndrome in school-aged children manifested with asthenic and vegetative disorders. Rehabilitation sanatory factors have favourable effect on the clinical manifestations of post-COVID syndrome, as well as the saliva concentration of monocytic chemotactic protein. Keywords: post-Covid syndrome, asthenia, children, monocyte chemotactic protein, rehabilitation.

ОЦЕНКА ЭФФЕКТИВНОСТИ «ПАНТОГЕМАТОГЕНА-С» В КОМПЛЕКСНОЙ МЕДИКО-ПСИХОЛОГИЧЕСКОЙ РЕАБИЛИТАЦИИ ВОЕННОСЛУЖАЩИХ С АСТЕНИЧЕСКИМ СИНДРОМОМ В УСЛОВИЯХ САНАТОРИЯ

Introduction. The utilization of the dietary supplement "Pantohematogen-C" within the medical and psychological rehabilitation program for military personnel with secondary asthenic syndrome in a sanatorium-resort setting has demonstrated its positive impact on normalizing key asthenia symptoms, including physical and mental exhaustion, vegetative disorders, and sleep disturbances. Aim. This study aimed to enhance the effectiveness of comprehensive medical and psychological sanatorium-resort rehabilitation for military personnel with asthenic syndrome using the dietary supplement "Pantohematogen-C". Materials and Methods. The study involved 39 male military personnel aged 24 to 59 years (average age 39.2±4.18 years), with 20 patients in the main group and 19 in the comparison group. The patients underwent a 21-day sanatorium rehabilitation program at the Military Sanatorium "Yeltsovka" of the Ministry of Defense of the Russian Federation. The rehabilitation program included various interventions such as diet therapy, gentle-training motor regime, physical therapy methods, daily dosed walking, exercise equipment, transcranial electrical stimulation (TES), iodine-bromine baths, and psychological correction. Additionally, the main group received the dietary supplement "Pantohematogen-C" three times a day, while the comparison group underwent only the procedures of the basic complex. The effectiveness of the rehabilitation measures was evaluated using several assessment tools. Results. Following the comprehensive sanatorium rehabilitation program, including "Pantohematogen-C", a significant decrease in physical and mental components of asthenia, an increase in activity on the MFI-20 scale, normalization of vegetative status, and improved sleep quality were observed. Patients also reported enhanced well-being, mood, and activity. Moreover, the program led to a statistically significant decrease in situational anxiety. Conclusions. The study has explored the potential and suitability of using Pantohematogen-C to enhance the effectiveness of the sanatorium-resort program for medical and psychological rehabilitation of military personnel with secondary asthenic syndrome. This intervention has shown promise in normalizing vegetative and psycho-emotional status, improving sleep quality, and increasing patient activity in sanatorium-resort organizations catering to these patient categories.

Clinical efficacy and safety of Picamilon in patients with progressive chronic cerebral ischemia

To study the efficacy and safety of the drug Picamilon with various therapy regimens in patients with stage II chronic cerebral ischemia (CCI). An open cohort clinical study involved 50 patients diagnosed with stage II CCI aged 51 to 69 years (average age 62.2±8.98 years). Patients received Picamilon first parenterally 200 mg (100 mg/ml, 2 ml) intravenously for 10 days, then orally in 50 mg tablets 3 times a day for 60 days. The total duration of therapy in the group was 70 days. The study included 3 visits (before treatment, after completion of the course, 1.5 months after completion of treatment). The dynamics of cognitive status according to the Montreal Cognitive Assessment Scale, vegetative disorders according to the A.M. Vane scale, neurological disorders according to the A.I. Fedin scale, and sleep quality according to the Ya. I. Levin scale were compared. The state of cerebral blood flow and endothelium was studied before and after treatment: dopplerography of cranial vessels, assessment of the level of methylated forms of arginine (ADMA, MMA, SDMA) and their ratios. The registration of adverse events against the background of therapy and the tolerability of treatment by patients was also carried out. Against the background of Picamilon treatment, a significant positive dynamics of the MoCA scale results was observed in the general sample of patients, increasing in the delayed period (20.9, 24.6 and 25.9, p<0.0001 and p=0.0006); sleep normalization was observed in 55% of patients by Visit 2 and in 81% of patients by Visit 3 (p<0.0001 and p=0.0025). Improvement of neurological functions is noted in 84% of patients, the score on the Fedin A.I. scale significantly decreases after treatment from 17.4±9.34 to 8.06±6.84 (p<0.0001) and to 5.31±5.71 in the delayed period (p=0.0002). Normalization of vegetative status was observed in 38% of patients with stage II CCI, and in 60% of cases there was a decrease in the severity of vegetative dystonia syndrome (p=0.0001). Picamilon therapy has high efficacy in assessing clinical outcomes (100%), good tolerability in 98% of patients and is characterized by a favorable safety profile (in 92% of patients). Picamilon significantly affects the parameters of cerebral hemodynamics: increases the linear velocity of blood flow, reduces the thickness of the intima-media complex and the resistance index. It affects markers of NO metabolism and endothelial function: significantly reduces elevated levels of ADMA and ADMA/MMA and (ADMA+SDMA)/MMA ratios. The use of Picamilon is effective in patients with stage II CCI in the form of step therapy contributes to a significant regression of neurological deficit, cognitive impairment, improvement of sleep quality and autonomic function; improves vascular endothelial function, reduces the risk of cardiovascular complications. Picamilon is a pathogenetic therapy agent that prevents the progression of CCI.

Integrative assessment of the effectiveness and safety of outpatient use of Picamilon

To study the efficacy and safety of the use of the drug Picamilon with various therapy regimens in patients with stage I of chronic cerebral ischemia (CCI). Material and methods. An open randomized comparative clinical trial included 44 patients with stage CCI aged 46 to 67 years (average age 55.6±6.76 years). Patients were randomized into two groups, patients of group 1 (n=23) received Picamilon orally in tablets of 50 mg 3 times/day for 60 days; group 2 (n=21) received Picamilon first parenterally at 100 mg i/m for 10 days, then in tablets of 50 mg 3 times/day for 50 days. The total duration of therapy was 60 days. The study included 4 visits (before treatment, 10 days later, 60 days later, 1.5 months after completion of treatment). The dynamics of cognitive status were assessed according to the Montreal Cognitive Function Assessment Scale (MoCA), vegetative disorders on the A.M. Wayne scale, neurological disorders on the A.I. Fedin scale, and sleep quality on the Ya.I. Levin scale. The study of the state of cerebral blood flow (dopplerography of intracranial vessels) and endothelial function (assessment of the level of methylation. During treatment, in the total sample of patients, there was a positive trend in the results of the MoCA scale, increasing in the delayed period (24.9/26.5/28.3 points, p=0.022 and p<0.001); improvement in sleep quality in 50% of patients by visit 3 and in 84% by visit 4, in the 2nd group the effect occurred in 28% of patients, in the 1st - in 11%, by the end of the study the effect was comparable (p=0.508). Improvement according to Fedin A.I. scale noted in 77% of patients, values decreased from 11.9±8.3 to 6±6.1 points (p<0.0001) and to 2.77±4.43 points by visit 4 (p<0.0001). Normalization of autonomic functions was observed in 29% of patients (p=0.024) without intergroup differences. Picamilon therapy showed high efficacy in terms of clinical outcomes (up to 89%), good tolerability (98% of patients) and a favorable safety profile (less than 8.6% of AEs). The use of Picamilon was accompanied by an increase in the linear velocity of blood flow, a decrease in the thickness of the intima-media complex and the resistance index; a decrease in elevated ADMA concentrations and ADMA/MMA and (ADMA+SDMA)/MMA ratios. The use of Picamilon is effective in patients with stage I CCI, contributes to a significant regression of neurological deficits, cognitive impairment, improved sleep quality and autonomic function; improves vascular endothelial function, reduces the risk of atherosclerosis and cardiovascular complications in patients. The optimal duration of therapy with Picamilon in stage I of chronic cerebral ischemia is 2 months.

Состояние нервно-психического здоровья школьников при различном времени использования мобильных электронных устройств

Uncontrolled screen time is a worldwide menace to health of the population. Today, the state of neuropsychiatric health of schoolchildren depends on various factors, including screen time, i.e., the time they spend using mobile electronic devices. This study aimed to investigate how different screen time durations affect the said neuropsychiatric health of this population group. In the 2022–2023 academic year, we surveyed 109 Moscow schoolchildren (35 boys and 74 girls) using questionnaires compiled by A.M. Vane (identification of signs of vegetative symptoms) and S.K. Kulakov (identification of internet addiction). The mean age of the participants was 14.9 ± 0.12 years. The children were divided into two groups: those staying within the regulated limit of mobile screen time (group 1, n = 11), and those exceeding that limit (group 2, n = 98). In group 1, the average mobile screen time, as measured for one month, was 110.50 ± 10.00 minutes per day, in group 2 — 345.00 ± 15.00. The average Vane questionnaire scores differed significantly between the groups (p ≤ 0.01): 12.30 ± 1.89 points in group 1 and 22.54 ± 1.16 points in group 2. Signs of vegetative symptoms were registered in 45.9% of group 1 participants and 63.6% of group 2 participants (p ≤ 0.01). The average Kulakov questionnaire scores differed significantly between the groups (p ≤ 0.05): 28.7 ± 1.88 points in group 1 and 37.1 ± 1.09 points in group 2. Schoolchildren who exceed the regulated mobile screen time limit are at risk of developing vegetative disorders and internet addiction.

Alternative therapy of menopausal vegetative disorders in women taking the metabolic status into account

Research objectives: to study the clinical effectiveness of alternative complex therapy of vegetative syndrome in menopausal patients using L-arginine and xylitol drugs. Materials and methods. The clinical prospective study included 50 patients in the early postmenopausal period with natural menopause, neurovegetative and psychoemotional manifestations of the climacteric syndrome. According to the Life extension strategy, patients received intravenous L-arginine (Tivortin drug) and xylitol solution with electrolytes (Xylat drug) for endothelial protection and correction of insulin resistance in order to treat climacteric syndrome. Modified Kupperman menopausal index, serum triglyceride, cholesterol, high-density lipoprotein, low-density lipoprotein, and very-low-density lipoprotein levels were determined in all women. Examinations were performed before the start of therapy and 3 months after the end of treatment.Results. The Life extension therapeutic strategy as an alternative comprehensive therapy of the vegetative syndrome in menopausal patients contributed to a reliable reduction of the manifestations of the climacteric syndrome. The advantage of combined therapy involving L-arginine and xylitol was manifested in a significant decrease in diastolic blood pressure (p = 0.043); reduction of the Kupperman index (p = 0.002) and the average score of vasomotor symptoms (p = 0.02). There was also a significant decrease in the serum level of insulin (p = 0.00007), HOMA index (p = 0.01), low-density lipoproteins (p = 0.04), and triglycerides (p = 0.03). The selected therapy was well tolerated during the observation period.Conclusions. The combined therapy involving L-arginine and xylitol in the early postmenopausal period with neurovegetative and psychoemotional manifestations of the climacteric syndrome had a pronounced clinical effect, which consisted in a significant reduction of vegetative disorders and stabilization of carbohydrate and lipid metabolism. The given therapeutic strategy can be considered as an alternative therapy in patients with climacteric disorders when phytotherapy is ineffective and when there are contraindications or limitations to menopausal hormone therapy. The results of this study showed the safety of the Life extension strategy.

Stylohyoid syndrome in the practice of doctors of various specialties

Objective. Based on the analysis of the data presented in the literature and own clinical observation, to develop an understanding of the frequency of occurrence and clinical signs of a fairly rare pathology – stylohyoid syndrome. Consider the peculiarities of the pathological process and give recommendations for working with patients of this category.Materials and methods. The material for the analysis was the data of studies by domestic and foreign authors concerning etiology, pathogenesis, diagnosis, differential diagnosis and treatment of stylohyoid syndrome published over the last 40 years. A descriptive method was used in the study. The article presents our own clinical observation and uses data from the medical record of an inpatient with verified “stylohyoid syndrome”.Results. The stylohyoid syndrome occurs in 4.0-10.3% of people who report constant pain in the pharynx, oral cavity, face and neck, dysphagia, hearing loss, limited mobility of the head, vegetative disorders. It has been determined that a set of clinical and radiation data is required for the diagnosis of the stylohyoid syndrome, the most significant of which are: abnormal length of the stylod process, a significant angle of its deviation, which leads to pain due to the pressure of the latter on the surrounding anatomical formations. The main method of treatment is surgical.Conclusion. The results of the study have an applied component: they indicate the necessity to perform radial examination, to consult related specialists for differential diagnostics in persons with suspected stylohyoid syndrome and contain an organizational and tactical element: they determine surgical treatment as the main method of specialized care for this category of patients.

Grafting Compatibility and Environmental Conditions on Soilless Eggplant (Solanum melongena) Grown in the Mediterranean Greenhouse

Grafting techniques represent an efficient tool to enhance plant growth and development. The study aims to explore the effects of different grafting combinations on the growth of eggplants under diverse greenhouse conditions. Eggplant cultivar Black bell (Bb) was employed as scion, while the hybrid F1 Beaufort (Be) and Solanum torvum (To) were utilized as rootstock. The hypothesis behind this study pertains to grafting incompatibility with Beaufort F1. It postulates that this incompatibility can be mitigated by manipulating soil and greenhouse temperatures. The experimental factors encompassed plant combinations (Bb, Be/Bb and To/Bb), as well greenhouse and substrate temperature (both cold or heated). The Be/Bb combination showed higher values of plant vegetative traits, but it exhibited low grafting compatibility. Additionally, physiological analysis confirmed the presence of excessive growth and vegetative disorder within the Be/Bb combination. Examination of the xylem vessels revealed notable differences between the grafting combination involving Bb and the rootstock F1 hybrid Be/Bb, compared to the one with To/Bb and the non-grafted Bb. Specifically, the area, diameter and number of xylem vessels were approximatively 45% higher in Be/Bb than in To/Bb and the non-grafted Bb. Furthermore, a robust linear correlation was observed between plant height with morphometric and physiological traits, except fruits sets. This study lays the basis for a novel protocol for agriculture, addressing the excessive vegetative growth in rootstocks regulating air and substrate temperatures.

Psychological defenses in patients with autonomic nervous system disorder

In order to identify psychosocial characteristics of individuals with autonomic nervous system disorder (ANSD), 104 patients of the organized population of Petrozavodsk (n=104; mean age 36.8±10.7 years; gender index 1:1) were examined. The control group included healthy individuals (n=30; mean age 36.1±5.5 years; gender index 1:1; p=0.761). The ANSD diagnosis was confirmed by means of the Questionnaire for identifying signs of vegetative changes and the Study scheme for detecting signs of vegetative disorders (Vein A.M. et al., 2003), as well as by palpatory examination using the Markelov-Naryshkin method. The calculation of the Kerdo index in the patients with ANSD showed a predominance of sympathicotonia (40.38% and 50.0% of cases among men and women, respectively) over parasympathicotonia (21.15% of the patients without gender differences). In addition, psychological defenses (PD) were investigated using the method of the Life Style Index (LSI) (R. Plutchik, H. Kellerman, R. Conte, 1979). It was found that the patients with ANSD were characterized by an increase in the overall stress index of psychological defense mechanisms due to “regression” (22.28±15.45 (0) / 35.57±14.6 (9.33±5.31)), “projections” (23.97±17.61 (10.78±3.59) / 31.23±18.05 (12.83±6.11)), and “substitutions” (20.43±12.74 (5.65±1.15) / 16.29±10.85 (6.67±3.98)), with statistically rarer use of “denial” (36.71±15.42 (47.68±13.98) / 34.18±17.64 (51.8±14.37) percentiles among men with ANSD (healthy individuals) / women with ANSD (healthy individuals); p=0.001). Gender specificity was noted only in relation to the PD “reactive education”, with its predominant use by women 37.88±23.71 (compared with 23.27±19.37 percentiles in men; p&lt;0.01). The identified psychosocial predictors are aimed at timely diagnosis and optimization of medical and psychological rehabilitation of patients with ANSD.

QUALITY OF LIFE OF A PATIENT WITH PERSISTENT COMPLICATIONS AFTER SARS-COV-2 INFECTION REQUIRING URGENT SURGICAL INTERVENTION – ENDARTERECTOMY WITH EMERGENCY ANGIOPLASTY OF AN INFLAMED, BLEEDING RIGHT INTERNAL CAROTIDARTERY (RICA) USING THE TRANS-CAROTID ARTERY REVASCULARIZATION(TCAR)

SUMMARY The purpose of this study was to determine the quality of life of a patient with persistent complications of SARS-CoV-2 infection requiring urgens surgical intervention – endarterectomy with emergency angioplasty of an inflamed, bleeding Right Internal Carotid Artery (RICA) by direct access via Right Common Carotid Artery (RCCA), known as Transcarotid Artery Revascularization (TCAR).A patient in her 60s was infected with the SARS-CoV-2 virus and contracted COVID-19 in March 2022, as confirmed by RT PCR antigen test. The infection was followed by short- and long-term complications, many of which can be linked to COVID. These include significant weakness persisting for months after the illness, rapid weight loss of 25 kg, sleep disturbances, chronic fatigue, severe dizziness, onset of diabetes, decrease dimmunity with increased periodontal inflammation (including formation of a periapical abscess of a molar tooth) and secondary suppuration of the submandibular lymphnodes, one of which lying jacent to the right internal carotidartery (RICA). This accumulation of symptoms led the patient to seek medical and neuropsychological help. Test ingusing the Beck Depression Inventory (BDI) confirmed depression, with vegetative disorders being the most predominant. Eight months after undergoing COVID-19, the patient suffered a Transient Ischemic Attack (TIA). The accumulation of diseases (diabetes mellitus, stage III hypertension and TIA) had a dramatic impact on the patient's health, including life-threatening conditions.A vascular surgeon consulted the patient advised immediate surgical treatment: carotid endarterectomy. The urgency of the situation was exacerbated by bleeding during the operation from the operated, secondarily inflamed wall of the RICA (lying adjacent to the suppurated submandibular node).This prompted an emergency decision for an endovascular procedure: the implantation of a stent covered with water-proof material (peripheral stent graft). This was made by a direct access via puncture of the common carotid artery (RCCA) below the endarterectomy level (TCAR).The SF-36 questionnaire was chosen to measure health-related quality of life (HRQOL).The SF-36 results are presented in such a way that higher scores correspond to fewer complaints, indicating better health and higher quality of life. Before revascularization, the patient's HRQOL was found to be lower, which was related to the negative impact of long COVID, while after the procedure, the quality of life gradually improved in subsequent surveys. A significant difference was found in physical function, with a mean score of 66.0 (p&lt;0.001) compared to a score of 94.9 (9.4) for 100 age-matched health subjects. A similar result was found in the physical role (p &lt; 0.001). The patient's overall quality of life score was 331.0 compared to a score of 578.0 (111.9) for age-matched normal healthy people.Better quality of life in patients with long COVID is an important therapeutic goal that can be achieved through comprehensive, multispecialty treatment for both physical and psychological conditions.

INFLUENCE OF PERSONALITY OF CHILDREN AND ADOLESCENTS OF THE UZBEK POPULATION ON MANIFESTATIONS AND DEVELOPMENT OF NEUROCIRCULATORY DYSTONIA

The relevance of studying the personality characteristics of children with vegetative vascular dystonia (VVD) is dictated by the fact that many psychosomatic disorders (ischemic and hypertension diseases, bronchial asthma, gastric ulcer and 12 bc, neurodermatitis, etc.) originate in childhood and their primary manifestations are vegetative disorders. According to the literature, among the children with non-communicable diseases who go to the doctor, 50-75% are patients with VVD. Purpose of the study. Study of the influence of the mental state and personality characteristics of patients on the manifestations and development of NCD in children and adolescents of the Uzbek population. Material and methods. We studied 43 patients with NCD (18 boys and 25 girls) aged 7 to 16 years with hypotonic, hypertensive and cardiac types. In the examined group of patients with NCD, children with hypertensive (46.5%) type prevailed. Patients (39.5%) were diagnosed with hypotonic NCD, and in 14 patients with cardiac type. For the study of individual - typological and personal characteristics of children, in addition to clinical and pedagogical observations, traditional experimental - psychological methods were used, allowing the most differentiated approach to the analysis of the personality of a sick child. The results of the study were subjected to variational-statistical processing: mean values (X), standard deviation (T) and its errors (+m), testing hypotheses from the normal distribution were tested by Student's t-test. Conducted correlation and dispersion analysis according to the program. Results: patients with NCD are characterized by a pronounced increase in emotional stress, difficulty in making interpersonal contacts and contributing to the violation of the psycho-vegetative regulation of the individual. The predominance of the desire for well-mannered forms of behavior, combined with conscious self-control, prevents the reaction of negative emotions, which contributed to the long-term preservation of emotional stress and further difficulties in adaptation. Patients with NCD usually had combinations of disharmonious personality traits, which led to the appearance of intrapsychic conflicts between dominant and mutually exclusive types of needs. The actual mental state of children with NDC determined by the Kettell method as a whole manifests itself as a personality of a highly neurotic response, which confirms the connection between NDC and personality traits. Conclusions: These intrapsychic conflicts underlay violations of social adaptation in the school and family spheres, and also prevented psycho-vegetative adaptation, which manifested itself in psychopathological and vegetative-somatic disorders in this disease.

Experience with nusinersen as a pathogenetic therapy in adult patients with spinal muscular atrophy 5q in the Republic of Bashkortostan

Background. Spinal muscular atrophy (SMA) affects 1 in 11,000 people. Until 2016, this was considered an incurable disease, but after the approval of nusinersen, the situation has changed. The efficacy of nusinersen therapy is also known in adult patients, although research is limited due to the majority of studies in infants and children. Nusinersen has been included in the list of “Vital and Essential Medicines” since 2021.Aim. To analyze the experience of using nusinersen as a pathogenetic therapy for patients over 18 years of age with SMA 5q in the Republic of Bashkortostan.Materials and methods. We examined eight patients receiving pathogenetic therapy with nusinersen (SMA type 2 – 34.5 %, SMA type 3 – 65.5 %). The Hammersmith Functional Motor Scale Expanded (HFMSE) and the Revised Upper Limb Module (RULM) were used for evaluating the effectiveness of therapy.Results. The median increase on the HFMSE scale was +2 points (7.5, with the initial 5.5) and on the RULM scale – +4.5 points (17 points, with the initial 12.5). Clinically, this was expressed in an increase in muscle strength, an increase in daily activity; a decrease in bulbar, respiratory and vegetative disorders can also be noted. Subjectively, positive dynamics was noted in the increase in working capacity, improvement of the emotional background.Conclusion. The use of the drug nusinersen in adult patients with SMA 5q in some cases provides clinical improvement. The presence of an “overall response” is defined as clinically significant change in one assessed measure of motor function.

Influence of hysterectomy due to leiomyoma on woman’s psychological status

The objective: to study the clinical-psychopathological features and psycho-emotional symptoms and borderline mental disorders in women of reproductive age after hysterectomy due to leiomyoma.Materials and methods. An assessment of the psychological state of 160 women after hysterectomy for leiomyoma was carried out. 90 patients of them (average age – 45.9±1.3 years old) had transvaginal hysterectomy, both classic and laparoscopically assisted one with opportunistic salpingectomy (I group) and 70 patients (average age – 47.2±1.6 years old) – abdominal hysterectomy with opportunistic salpingectomy (II group). The control group included 50 women 45.7±1.3 years old with asymptomatic leiomyoma. Clinical psychopathological, anamnestic and experimental psychological methods were used. Pathopsychological methods included methods of visual presentation of the personality profile using the Minnesota Multifaceted Personality Questionnaire. The survey was conducted at the pre-operative period, during the adaptation period and during 12 months. Statistical processing of monitoring data was carried out according to the φ-criterion using the statistical analysis software package STATISTICA v. 10 and Microsoft Office Excel application. Results. The results of the questionnaire determined that 44 (48.89 %) patients of the I group and 33 (47.14 %) women of the II group had disorders related to anxiety, and 6 (6.67 %) and 5 (7 .14 %) of the patients of both groups, respectively, were diagnosed depression before surgical treatment. After hysterectomy the number of patients with an anxiety disorder increased to 52 (57.78 %) in the I group and 41 (52.57 %) – II group, with depression – to 10 (11.11 %) and 8 (11.43 %) women, respectively. However, the psychopathological analysis with psychologists in 12 months after hysterectomy determined affective symptoms in 11 (15.7±7.0 %), and latent depression with a somatopsychic correlation, manifested by a feeling palpitation, cardialgias, vegetative disorders was found in 8 (11.4±6.0 %) cases. The type of personality accentuation influenced the development of psychoemotional manifestations. In this structure, the largest rate consisted of psychoasthenic and hysterical character traits. The age of the patient was important when analyzing additional psychological factors. Women under 44 years old associated hysterectomy with loss of femininity with premature aging of the organism. The patients with successful implementation of their role in the family and society had better postoperative psychological adaptation.Conclusions. There is a trend toward an increased number of anxiety and depressive disorders after hysterectomy in women with leiomyoma. After 12 months, affective symptoms were present in 11 (15.7±7.0 %) cases and in 8 (11.4±6.0 %) cases – hidden depression. Postoperative rehabilitation should include a consultation with a psychologist to identify and treat borderline mental disorders, which will lead to the initiation of compensatory and adaptive reactions of the body and the normalization of the psycho-emotional status.