With the rapid development of urbanization and population growth, the ecological environment in the Yellow River Delta has undergone significant changes. In this study, Landsat satellite data and Google Earth Engine (GEE) were utilized to dynamically evaluate the changes in eco-environmental quality in the Yellow River Delta region using the remote sensing ecological index (RSEI). Additionally, the CASA model was used to estimate net primary productivity (NPP) and explore the relationship between vegetation NPP, land-use and land-cover change (LUCC), and eco-environmental quality to reveal the complexity and related factors of eco-environmental quality changes in this region. The results show that: (1) Over the past 20 years, the eco-environmental quality in the Yellow River Delta region has changed in a “V” shape. The eco-environmental quality near the Yellow River Basin is relatively better, forming a diagonal “Y” shape, while the areas with poorer eco-environmental quality are mainly distributed in the coastal edge region of the Yellow River Delta. (2) The response of vegetation NPP to eco-environmental quality in the Yellow River Delta region is unstable. (3) Urban construction land in the Yellow River Delta region is strongly correlated with RSEI, and the absolute value of the dynamic degree of land use is as high as 8.78%, with significant land transfer changes. The correlation between arable land and RSEI is weak, while coastal mudflats are negatively correlated with RSEI, with the minimum absolute value of the dynamic degree of land use being −1.01%, and significant land transfer changes. There is no correlation between forest land and RSEI. Our research results can provide data support for the eco-environmental protection and sustainable development of the Yellow River Delta region and help local governments to take corresponding measures.