The study posed and solved the problems of theoretical and methodological substantiation of the management of modeling of the provision of vital functions of the population and the functioning of national economic facilities. An approach to modeling the level of life and stability of the region’s dynamic systems is presented. The mathematical apparatus and methodological support were used using the methods of linear matrix inequalities and non-quadratic Lyapunov vector functions, together with the method of optimizing linear series of a combination of partial and average values of integrated socio-economic indicators. Methods for evaluating managerial decisions and differentiating regions at the level of constituent entities of the Russian Federation are proposed and tested using the example of Vladimir, Ivanovo and Ryazan regions. Studies have established that the level of economic viability of the population is a priority indicator in characterizing the level and quality of public administration and determining the differentiation of a region (territory). As a result of the analysis, we came to the conclusion that the solution to the problems of increasing the sustainability of the economic development of regional economies should be associated with the following processes: strategic management as a continuous process of substantiating and selecting promising goals for the sustainable development of the region and developing specific plans and programs to achieve these goals; financial modeling as a system of forms, methods and techniques for managing cash flows, financial and material resources of the region, aimed at ensuring sustainable development of the territory; optimization of production and technical activities as a set of methods, principles and management tools for the transition to modern technologies and environmental quality standards; legal regulation as a process of targeted impact on social, economic, environmental and social relations occurring in the region, with the help of legal (legal) institutions; formation of the organizational structure and strengthening of the administrative resource (intensification of the impact of socio-political forces on socio-economic development). In these conditions, one of the guarantors of the implementation of measures to achieve balance and sustainable development should be local authorities.