Net primary production (NPP) serves as a critical proxy for monitoring changes in the global capacity for vegetation carbon sequestration. The assessment of the factors (i.e., human activities and climate changes) influencing NPP is of great value for the study of terrestrial systems. To investigate the influence of factors on grassland NPP, the ecologically vulnerable Qinghai–Tibet Plateau region was considered an appropriate study area for the period from 2000 to 2020. We innovated the use of the RICI index to quantitatively represent human activities and analyzed the effects of RICI and climatic factors on grassland NPP using the geographical detector. In addition, the future NPP was predicted through the integration of two modeling approaches: The Patch-Generating Land Use Simulation (PLUS) model and the Carnegie–Ames–Stanford Approach (CASA) model. The assessment revealed that the expanded grassland contributed 7.55 × 104 Gg C (Gg = 109 g) to the total NPP, whereas the deterioration of grassland resulted in a decline of 1.06 × 105 Gg C. The climatic factor was identified as the dominant factor in grassland restoration, representing 70.85% of the total NPP, as well as the dominant factor in grassland degradation, representing 92.54% of the total NPP. By subdividing the climate change and human activity factors into sub-factors and detecting them with a geographical detector, the results show that climate change and anthropogenic factors have significant ability to explain geographic variation in NPP to a considerable extent, and the effect on NPP is greater when the factors interact. The q-values of the Relative Impact Contribution Index (RICI) and the RICI of the land use change NPP are consistently greater than 0.6, with the RICI of the human management practices NPP and the evapotranspiration remaining at approximately 0.5. The analysis of the interaction between climate and human activity factors reveals an average impact of greater than 0.8. By 2030, the NPP of the natural development scenario, economic development scenario (ED), and ecological protection scenario (EP) show a decreasing trend due to climate change, the dominant factor, causing them to decrease. Human activities play a role in the improvement. The EP indicates a positive expansion in the growth rate of forests, water, and wetlands, while the ED reveals rapid urbanization. It is notable that this is accompanied by a temporary suspension of urban greening.