The aim of this study was to investigate the effect of structural changes in variable fertilizer application devices on the distribution of particle deposition in UAVs. With the rapid development of drone technology, particularly in particulate spreading, drones have demonstrated significant potential due to their efficiency and precision. This paper evaluates the impact of different variable adjustment modes of the device on particulate deposition distribution through drone spreading experiments and particulate deposition data analysis. In this study, device structure change is the main variable factor, and flight altitude, flight speed and ambient wind speed are single quantitative factors. Experiments were conducted by varying the structure of the device to test the detailed deposition distribution of the device under group a, b, and c structures. Experimental results indicate that by choosing different variable combinations, the spreading device can achieve various fertilizer deposition states to meet regional needs. Among all 27 variable groups, the fertilizer particle deposition data for group b1b2b3 is relatively uniform, with three-quarters of particulate deposition values being 3 g/m2 and the maximum value being 4 g/m2. However, even with a relatively uniform distribution of fertilizer particles, the coefficient of variation for group b1b2b3 remains high (36.5%), with a range of 4.5% to 41%. Under different group adjustments, the particle distribution shows the smallest variability range in group b1b2b3, with a range of 15.71–26.44% and a variability difference of 10.73%. The particle distribution shows the largest variability range in group a1a2b3, with a range of 0.78–35.06% and a variability difference of 34.28%. These research conclusions provide important guidance for the study and practice of drone spreading systems.