The main purpose of this paper is to construct interacting and non-interacting Tsallis holographic dark energy models in an anisotropic and homogeneous Bianchi type-VI0 space time within the framework of a scalar tensor theory proposed by Saez and Ballester (1986). For this purpose, we use the relationship between metric potentials of the model and varying deceleration parameter to solve the Saez–Ballester field equations. In order to study the physical behavior of the models, we obtain some well-known cosmological parameters like deceleration, equation of state, statefinder, Om diagnostic parameters, and ωT - ωT′ planes of the models. Also, we observe that in our non-interacting and interacting models deceleration and equation of state parameters support the recent observational data.