The speed at which educators have embraced new technologies during the COVID-19 pandemic has been remarkable. This pivot to virtual instruction has been particularly diffcult in courses where hands-on experiences are the norm, such as in anatomy and physiology laboratory courses. Now with the transition back to mostly in-person instruction, the anatomy and physiology lab environment has faced a new set of challenges where the want to return to a strictly hands-on experience is being met with the need to still maintain flexibility and accessibility for students placed in quarantine. The anatomy and physiology lab curriculum at the University of the Incarnate Word (UIW) has adapted to this varied set of needs by adopting the use of the web-based laboratory software platform, Lt. Students in introductory anatomy and physiology labs surveyed during strictly virtual semesters reported a high level of satisfaction with the Lt lab software. Ratings regarding ease of use, support of learning, and overall ratings increased each semester with the highest ratings occurring during the recent semesters where instruction returned to mostly in-person and hands-on (Fall 2021 – Spring 2022). Interestingly, beginning in 2022 and continuing into fall of 2023, ratings of overall satisfaction began to decrease. Although it is currently diffcult to determine the root cause of this decrease in satisfaction, we speculate that many students are becoming fatigued with the continued use of seemingly virtual labs. Although most lab exercises are hands-on and include dissections and live physiological recordings, we think that the continued use of a virtual interface is too reminiscent of learning under quarantine conditions. Even with variations in ratings regarding Lt use in our introductory anatomy and physiology laboratories, our data still help to support the widely held belief that students perform best, and that instruction is more effective with face-to-face laboratory courses. With our continued use of Lt, we have found an effective combination of virtual and in-person instruction that best fits our course outcomes while still supporting the flexibility and accessibility our students require. Research reported in this poster was supported by the University of the Incarnate Word Offce of Research and Graduate Studies. This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.