Since processed crude oil products are very vulnerable (susceptible) and highly flammable to cause massive catastrophes, such as fire and explosion, which are frequent and can create a chain reaction (Domino effects). This research was carried out at the Bulk Oil Storage and Transportation LTD depot on the Accra plain in Ghana where gasoline and Gasoil are stored. The research was conducted on a flammable gasoline area subjected to a vapor cloud explosion and the hazardous zone. Analyzing domino effects, propagation of a gasoline flammable vapor cloud caused by the explosion, ALOHA (Areal Location of Hazardous Atmospheres) software was used to find out how to apply effective safety measures to prevent future risks at any BOST facilities across the country. After the analysis, it was realized that 5.0 miles to the west-south-west the fuel concentration in the air was 2100 ppm lower than the explosive limit (LEL), and could not be as severe as that at 2.3 miles distance from the source point (12600 ppm LEL) with a greater fuel concentration in the atmosphere. The results made available would be useful in maximizing (improving) safety at the facility, residential area, and as well as minimizing future incidents.