An intermediate fluid vaporizer (IFV) is a typical vaporizer of liquefied natural gas (LNG), which is used in a large number of LNG terminals. Since it requires a large supply of seawater during its operation, it generates a lot of energy consumption. In this study, to reduce the seawater consumption in the regasification system, the heat transfer process was first numerically calculated, and the heat transfer coefficient of the IFV was determined for different seawater inlet temperatures, seawater flow rates, and LNG flow rates. The calculation results of the heat transfer coefficient were integrated into the numerical model in HYSYS, and the minimum seawater flow of the IFV under different working conditions was obtained. For receiving terminals using multiple IFVs, this study programmed calculations based on optimization software. The operating configuration of the IFVs under different operating conditions was optimized to reduce the consumption of seawater in the regasification system of the LNG terminals.