Patient care providers, especially nurses, contribute to the occurrence of errors that threaten patient safety. These errors can have an impact on the implementation of nurses in the implementation of patient safety. One of the factors causing the implementation of patient safety does not run optimally because of the nurse's workload. This paper described about analyze the relationship between workload and nurse performance on the implementation of patient safety during the Covid-19 pandemic and analytical study with a cross-sectional approach. The research was conducted at Salak Hospital, Pakpak Bharat Regency also population was 100 people and the entire population was sampled. Data analysis used univariate, bivariate with chi-square test, and multivariate with multiple logistic regression at 95% confidence level (p=0.05). The results show that there is a relationship between physical workload, discipline, and cooperation on the implementation of patient safety during the Covid-19 pandemic, p < 0.05. While the unrelated variables are psychological workload, service orientation, integrity, and commitment, p> 0.05. The variable that has the biggest relationship to the implementation of patient safety during the Covid-19 pandemic is the physical workload with a value of Exp(B)/OR = 13,453. The management of Salak Hospital in Pakpak Bharat Regency needs to provide education and training to all nurses related to the implementation of patient safety during the Covid-19 pandemic, as well as to divide tasks fairly to all nurses so that the physical workload borne by each nurse is not unequal so that it has an impact on performance. who are not good at implementing patient safety. Keywords: Nurse Workload, Nurse Performance, Patient Safety Implementation.