This work presents a simple integer-only instruction set architecture and microarchitecture derived from One Instruction Set Computers (OISCs) and embedding multiple execution modes ( ${m}$ OISC), capable of running at a reasonable performance level to enable basic usability in microcontroller applications. The purpose of ${m}$ OISC is to enable simple data transfer tasks and run small programs while maintaining ultimate simplicity. We present the internal organization for a computer architecture including an 8bit I/O register, and 64kB central Random Access Memory (RAM), organized in two-bytes words. The processor can run code generated assuming an OISC or a Complex Instruction Set Computer (CISC) scheme (op-code based), depending on the programmer’s demands and based on the initial setting of a register during start-up. To enable practical applications and demonstrate successful exploitation of ${m}$ OISC in view of integration in a compiler back-end, we designed a custom Proof-of-Concept (PoC) software design toolchain based on LLVM and clang . Although not targeting all the features of commercial ISA, the toolchain is capable of compiling C code from LLVM intermediate representation or generating ${m}$ OISC code translated from ARM, x86, RISC-V, and MIPS assembly. The toolchain also enables practical Value Change Dump (VCD) simulations output with graphical plots of the CPU state and associated symbols. A PoC microcontroller system has been synthesized in a low power Field Programmable Gate Array (FPGA) and verified in a basic wireless telemetry application including a Synchronous Peripheral Interface (SPI) RFM9x Long RAnge (LoRA) transceiver and a MAX30205 Inter Integrated Circuit (I2C) temperature sensor, using its 8bit I/O port, with software bus interface implementation. ${m}$ OISC occupies ~6% of resources on a Cyclone 10LP FPGA, for 1397 Adaptive Look-Up Tables (ALUTs) and 461 dedicated logic registers. The measured dynamic current consumption of the complete FPGA board with synthesized ${m}$ OISC is 12mA at 100MHz clock.