Valsalva Graft Research Articles

Reimplantation valve-sparing aortic root replacement with the Valsalva graft: what have we learnt after 100 cases?

Reimplantation valve-sparing aortic root replacement has been increasingly performed with improving perioperative and mid-term results. The success of this operation primarily depends on preserving the highly sophisticated dynamic function of the aortic valve by recreating an anatomical three-dimensional configuration similar to the normal aortic root, thus minimizing the mechanical stress and strain on the cusps. Over the years several techniques have been proposed to reproduce the sinuses of Valsalva. We reviewed our experience with aortic valve reimplantation by means of a modified Dacron graft that incorporates sinuses of Valsalva, in a series of 100 consecutive patients. During a 60-month period, 100 patients with aortic root aneurysm underwent aortic valve reimplantation using the Gelweave Valsalva prosthesis. There were 74 males and the mean age was 60+/-12 years (range 28-83 years). Five patients had the Marfan's syndrome, 15 had a bicuspid aortic valve. Cusp repair was performed in five patients. The mean follow-up time was 28.6 months (range 1-60). Transesophageal echocardiogram was performed at the end of each procedure to assess the aortic valve in terms of competence, dynamic motion and level of coaptation within the graft. There was one hospital death and two late deaths. Overall survival at 60 months was 91.7+/-5.1%. Five patients developed severe aortic incompetence (AI) during follow-up requiring aortic valve replacement (AVR). The 60 months freedom from re-operation due to AI was 90.9+/-4.4%. One patient had moderate AI at latest echocardiographic study. The 60 months freedom from AI>2+ was 91.6+/-7.9%. Cox regression identified cusp's repair as independent risk factor (P=0.001) for late reimplantation failure (AVR or AI>2+). There were no episodes of endocarditis and the majority of the patients (88%) were in New York Heart Association functional class I. The aortic valve reimplantation with the Gelweave Valsalva prosthesis provided satisfactory mid-term results. An accurate assessment of the level of coaptation of the aortic cusps in respect to the lower rim of the Dacron graft by means of intraoperative transesophageal echocardiogram at the end of each procedure is mandatory in order to avoid early reimplantation failure. Cusp's repair may play an important role in the development of late AI. However, long-term results are needed in order to define the durability of this technique.

Aortic Root Replacement in 372 Marfan Patients: Evolution of Operative Repair Over 30 Years

We reviewed the evolution of practice and late results of aortic root replacement (ARR) in Marfan syndrome patients at our institution. A retrospective clinical review of Marfan patients undergoing ARR at our institution was performed. Follow-up data were obtained from hospital and office records and from telephone contact with patients or their physicians. Between September 1976 and September 2006, 372 Marfan syndrome patients underwent ARR: 269 had a Bentall composite graft, 85 had valve-sparing ARR, 16 had ARR with homografts, and 2 had ARR with porcine xenografts. In the first 24 years of the study, 85% received a Bentall graft; during the last 8 years, 61% had a valve-sparing procedure. There was no operative or hospital mortality among the 327 patients who underwent elective repair; there were 2 deaths among the 45 patients (4.4%) who underwent emergent or urgent operative repair. There were 74 late deaths (70 Bentalls, 2 homograft, and 2 valve-sparing ARRs). The most frequent causes of late death were dissection or rupture of the residual aorta (10 of 74) and arrhythmia (9 of 74). Of the 85 patients who had a valve-sparing procedure, 40 had a David II remodeling operation; there was 1 late death in this group, and 5 patients required late aortic valve replacement for aortic insufficiency. A David I reimplantation procedure using the De Paulis Valsalva graft has been used exclusively since May 2002. All 44 patients in this last group have 0 to 1+ aortic insufficiency. Prophylactic surgical replacement of the ascending aorta in patients with Marfan syndrome has low operative risk and can prevent aortic catastrophe in most patients. Valve-sparing procedures, particularly using the reimplantation technique with the Valsalva graft, show promise but have not yet proven as durable as the Bentall.

A modification of the Ross procedure to prevent pulmonary autograft dilatation

We present our initial experience in 10 patients operated on using a modified Ross operation. In our modification of the Ross operation the pulmonary autograft root was inserted in the Gelweave Valsalva graft to prevent dilatation of the neoaortic root. This type of graft was selected to match the discrepancy between diameters of the annulus and the sinotubular junction of the autograft and to preserve the characteristic configuration of the native root. In our group of 10 patients operated consecutively by this technique there was no change in the geometry of the neoaortic root in the follow-up 3-19 months (mean 14.6 months).

Valve-Sparing Aortic Root Replacement With the Valsalva Graft

Valve-Sparing Aortic Root Replacement With the Valsalva Graft

Biological Bentall procedure with a Valsalva graft for a small aortic root

Biological Bentall procedure with a Valsalva graft for a small aortic root

Sorin Solo stentless valve: extended adaptability for sinotubular junction mismatch

Stentless valve continence is affected by the implantation technique, annular symmetry and dilatation of the sinotubular junction. We tested in vitro how the Sorin Solo stentless pericardial valve adapts to a slightly dilated sinotubular junction. Stentless Sorin Solo aortic valves (25 mm) were sutured into a 32-mm Valsalva graft suspending the commissures into the expandable region of the graft. The neo-aortic root was pressurized and sinotubular junction size progressively decreased by wrapping the neocommissural ridge with Dacron rings. Direct endoscopic view and ultrasound imaging were used to observe geometry and morphology of leaflets, regurgitation, height and level of leaflets coaptation. Fresh porcine valves of the same annular size were used as controls. Solo valves had mild regurgitation at baseline, became continent at 32 mm sinotubular junction size and remained continent at any size of reduction, with optimal coaptation height and level. Porcine valves had severe regurgitation at baseline, became continent at 30 mm and showed mild insufficiency and reduction of the coaptation level at a sinotubular junction of 28 mm. The Solo valve prevents residual valve regurgitation for a wider range of sinotubular junction mismatch when compared with natural porcine valves. This extended tolerance to sinotubular junction mismatch suggests a safe use of stentless valves even in suboptimal geometry roots.

Valve-sparing aortic root replacement with the vascutek valsalva graft

In the early iterations of the reimplantation techniques (David procedure) for aortic root replacement a straight Dacron tube, which provided anular stabilization but lacked sinuses, was used. Since the year 2000 the new Vascutek Gelweave Valsalva Graft is available. This graft is composed of a collar with horizontally oriented crimps, a skirt with vertically oriented pleats that make the sinus segment more compliant, and a long tubular segment with horizontal pleats. Upon implantation the skirted section streches horizontally recreating new sinuses of Valsalva. Laboratory evidence supports the contention that it facilitates valve opening and closure, thereby minimizing leaflet stress and strain. This video shows a reimplantation procedure in a patient with annular dilatation and a grade II aortic incompetence with a simplified operative technique using the Valsalva Graft.

Sinotubular Junction Size Affects Aortic Root Geometry and Aortic Valve Function in the Aortic Valve Reimplantation Procedure: An In Vitro Study Using the Valsalva Graft

Sinotubular junction (STJ) size in aortic valve reimplantation procedures is usually predetermined on the basis of experience or intraoperative mathematical calculations. Given the small coaptation reserve of aortic valve leaflets, small errors can produce an incompetent aortic valve. We tested in vitro the effect of geometrically changing the relationship between aortic annulus size and STJ size on aortic root geometry and aortic valve function. Twenty-five-millimeter diameter scalloped porcine aortic roots were reimplanted into 32-mm Valsalva grafts (Vascutek, Renfrewshire, Scotland), suspending commissures into the expandable region of the graft itself. Neoaortic roots were pressurized up to 100 mm Hg. Sinotubular junction size was then changed by wrapping the neocommissural ridge with Dacron rings of decreasing size. Geometry of the aortic root, anatomy of aortic valve leaflets, and extent of their coaptation were analyzed by direct endoscopic view and by ultrasound imaging techniques. Pressurizing unwrapped aortic root resulted in centrifugal displacement of commissures, aortic leaflets tethering and bending, and central aortic regurgitation. By reducing STJ size, coaptation height of aortic valve leaflets first increased to reach a maximum for an STJ size corresponding to 30 mm, and then decreased for further reduction of STJ size. Excess reduction of STJ size also resulted in prolapsed aortic leaflets and eccentric aortic regurgitation. In the reimplantation procedure performed with a Valsalva graft, aortic valve function and leaflet coaptation can be optimized by optimizing STJ size.

Acute Aortic Dissection with Intimal Layer Prolapse into the Left Ventricle

34-year-old male presented with acute onset ofsearing chest pain and was preoperatively diagnosedwith a Type A dissection limited to the ascendingaorta and arch. His preoperative troponin levels werenot elevated. The patient was scheduled for urgentrepairofaTypeAascendingaortaandtransversearchdissection under hypothermic circulatory arrest usingselective antegrade cerebral perfusion. The intraopera-tive transesophageal echocardiogram (TEE) examina-tion was performed using the Philips 5500 ultrasoundmachine with a Philips OmniPlane III ultrasoundprobe.Multiple views of the left ventricle (LV) revealed alarge intimal flap, prolapsing several centimeters intothe LV outflow tract during diastole. Severe (4)aortic insufficiency (AI) was diagnosed with colorflow Doppler, but regurgitant flow was containedwithin the prolapsing, intimal “sock.” No evidence ofregurgitantflowbeyondtheprolapsedintimallayerinthe LV outflow tract was demonstrated (Fig. 1). TheLV was dilated with moderate, global hypokinesis. Noregional wall motion abnormalities were noted andthe ejection fraction was estimated at 40%.Careful comparison of the aortic valve (AV) inmidesophageal (ME) long axis, and ME AV short axis(SAX) views suggested functional, bicuspid leafletexcursion, mild thickening, and no significant leafletcalcification or stenosis. The aorta was 2.6 cm at theAV annulus, 4.8 cm at the sinus of Valsalva, 7.2 cm atthe sino-tubular junction, and larger than 7.5 cm in thevisualized portion of the ascending aorta.Surgical inspection confirmed the diagnosis of bi-cuspid AV. The left/right coronary cusp was partiallyfused with a congenital cleft from the midportion tothe free leaflet edge. The intima of the sinus ofValsalva was 80% circumferentially torn, with ananchor point surrounding the left main coronary ostia.The surgeon performed a valve-sparing aortic rootreplacement using the David V re-implantation tech-nique with 32-mm Gelweave Valsalva graft (VascutekUSA Inc). The valve annulus was reduced in circum-ference with an aortic valvuloplasty, and the AV cuspcleft was closed with interrupted sutures. A buttonre-implantation of the left coronary ostia into the graftwas possible. The right coronary ostium was partiallydisrupted, and a saphenous vein graft bypass wasperformed.The patient was successfully weaned after 304 minof cardiopulmonary bypass, including 27 min of deephypothermic circulatory arrest. Moderate inotropicsupport was required. The cardiac function was de-pressed from baseline to an estimated 30% ejectionfraction. No new-onset regional wall motion abnor-malities were demonstrated.The postcardiopulmonary bypass TEE examinationrevealed a functional bicuspid valve with good excur-sion of leaflets and no subsequent aortic insufficiency.Planimetry of the effective orifice area measured 2.10cm

Panel Discussion: Session I—Ascending Aorta

Panel Discussion: Session I—Ascending Aorta

Adjustable Sinotubular Junction for Aortic Valve Reimplantation Procedures

Sinotubular junction size in aortic valve reimplantation procedures is usually predetermined on the basis of mathematical calculations and intraoperative measurements. We propose a new method for aortic valve reimplantation by which intraoperative measurements can be eliminated and sinotubular junction size adjusted after cross clamp removal to fit the patient's need. Aortic valve commissures are reimplanted in the expandable skirt of a Valsalva (Vascutek, Renfrewshire, Scotland) graft to realize an oversized sinotubular junction that is subsequently reduced to the proper size by wrapping, with Dacron rings of decreasing size, the neo-sinotubular ridge under transesophageal echocardiographic guidance.

Reimplantation Valve-Sparing Aortic Root Replacement in Marfan Syndrome Using the Valsalva Conduit: An Intercontinental Multicenter Study

Introduced by DePaulis in 2000, the Gelweave Valsalva graft (Sulzer Vascutek, Refrewshire, Scotland) is a modified Dacron conduit (DuPont, Wilmington, DE), with prefashioned sinuses of Valsalva. The aim of this study was to evaluate the mid-term results of the reimplantation valve-sparing aortic root replacement using the Gelweave Valsalva prosthesis in Marfan syndrome patients. A retrospective review was performed of 35 patients with Marfan syndrome in four centers who underwent the reimplantation valve-sparing aortic root replacement using the Gelweave Valsalva prosthesis. The patients were predominantly men, with a mean age of 36.5 +/- 12.6 years (range, 14 to 62 years). Two patients presented with acute type A dissections and underwent emergent operations. Elective hemiarch reconstruction using hypothermic circulatory arrest was required in 11 patients. Aortic valve cusp repair was performed in 2 patients. There were no operative or hospital deaths, and no patients died during follow-up. The mean follow-up was 19 months (range, 1 to 60 months). Significant (>2+) aortic insufficiency (AI), requiring aortic valve replacement, developed in 3 patients during follow-up that requiring aortic valve replacement. The 5-year freedom from reoperation owing to structural valve deterioration was 88.9% +/- 8.1%. There were no episodes of clinically significant thromboembolism. Reimplantation valve-sparing aortic root replacement with the Gelweave Valsalva prosthesis in Marfan patients provides satisfactory mid-term results, thus encouraging further use of this type of repair. However, long-term results are needed in order to define the durability of this technique.

Comparison of distensibility of the aortic root and cusp motion after aortic root replacement with two reimplantation techniques: Valsalva graft versus tube graft

The aim of this study is to evaluate distensibility of the aortic root and function of the aortic cusp after aortic root replacement using valve sparing procedure. Between October 1999 and August 2006, valve sparing aortic root replacements were performed in 39 patients who had annuloaortic ectasia (AAE) and aortic valve regurgitation. Reimplantation type of valve-sparing procedure was performed with a tube graft (n=12) or a Valsalva graft (n=27). Echocardiographic studies were performed six months after the operation comparing Valsalva graft (Group V, n=15), tube graft (Group T, n=5), and normal control (Group C, n=5). Percent changes in radius (PCR) of the aortic root were measured as indices of distensibility. Rapid valve opening velocity (RVOV/HR (mm/s/min)) and rapid valve closing velocity (RVCV/HR (mm/s/min)) of the aortic cusp were analyzed in each group. Root distensibility of sinus in Group T (1.9+/-1.1) was significantly smaller than Group C (7.2+/-1.8) (P=0.003). RVOV/HR in Group T was highest among the three groups (T: 48.2+/-6.2, V: 36.2+/-11.9, C: 33.7+/-9.6). RVCV/HR showed no difference among the three groups (T: 26.1+/-6.7, V: 40.7+/-16.6, C: 28.4+/-16.3). In conclusion, sinus distensibility of the Valsalva graft was well preserved and valve-opening characteristics with the Valsalva graft were identical to normal.

Valve-Sparing Aortic Root Replacement: Early Experience With the De Paulis Valsalva Graft in 51 Patients

Valve-sparing aortic root replacement for treatment of aortic sinus disease avoids the problems of prosthetic valves, but some patients suffer late valve incompetence as a result of leaflet distortion or annular dilatation. The reimplantation technique using the De Paulis Valsalva graft might improve late results of valve-sparing aortic root replacement by maintaining annular stability and re-creating sinuses that minimize leaflet stress. Retrospective review was conducted of all patients at our institution who underwent valve-sparing aortic root replacement using the Valsalva graft. Clinical data were obtained from hospital and clinic charts and patient contacts; echocardiograms were analyzed for aortic root dimensions and valve function. Between May 2002 and June 2005, 51 patients underwent valve-sparing aortic root replacement using the reimplantation technique with the Valsalva graft. Mean age was 33 +/- 15 years; 22% (11 of 51) were children, and 80% (41 of 51) were male. Primary indication for surgery was root aneurysm in all patients. Preoperative mean root diameter was 5.0 +/- 0.5 cm. Marfan syndrome was present in 67% (34 of 51), and 10% (5 of 51) had the newly described Loeys-Dietz syndrome. There were no operative or late deaths, and no patient required reoperation for bleeding. At mean follow-up of 1.8 years, there were no episodes of endocarditis or thromboembolism. Echocardiograms showed stability of the annulus and root dimensions on follow-up. No patient had more than 0 to 1+ aortic insufficiency or progression of aortic insufficiency. All were in New York Heart Association class I. Valve-sparing aortic root replacement using the Valsalva graft and reimplantation technique has excellent early results. Preservation of valve competence is encouraging, but long-term results will determine whether the anatomic design of this aortic root prosthesis is superior for preservation of valve integrity.

Aortic Valve-Sparing Operations: Early and Midterm Results

Aortic valve-sparing operations have provided very good clinical outcomes. However, there is still a debate about valve durability because of the absence of the Valsalva sinuses, and various techniques have been proposed to reproduce the native anatomy of the aortic root. We reviewed our total experience with aortic valve-sparing operations to determine early and midterm outcomes. Between July 2001 and August 2004, 85 patients underwent valve-sparing operations. There were 67 (78.8%) male and 18 (21.2%) female patients with a mean age of 58.8 +/- 14.6 years. Sixty-five patients with an aortic root aneurysm underwent the David I reimplantation technique, and a Gel-weave Valsalva graft was used in 57 patients. Twenty patients with an ascending aortic aneurysm underwent replacement of the ascending aorta with sinotubular junction reduction. There were 3 in-hospital deaths (3.5%) and 2 late deaths. Two of 4 patients with acute aortic dissection died. The 3-year survival for patients with an aortic root aneurysm was 95.4% +/- 2.6%, and for patients with an ascending aortic aneurysm it was 89.2% +/- 7.3 (P = .464). Seven patients developed 3 to 4+ aortic insufficiency, and 5 of them required aortic valve replacement. The 3-year freedom rate from grade 3 to 4 aortic insufficiency was 88.9% +/- 5.2% for patients with an aortic root aneurysm and 88.2% +/- 7.8% for those with an ascending aortic aneurysm. At 3 years, the freedom rates from late aortic valve replacement were 92.2% +/- 4.9% in the aortic root aneurysm group and 88.2% +/- 7.8% in the ascending aortic aneurysm group. Aortic valve-sparing operations showed excellent results in patients electively operated on for aortic root ectasia, and the results in acute aortic dissection were very disappointing. The Gelweave Valsalva prosthesis demonstrated ease of implantability and good reproduction of the pseuodosinuses. Long-term follow-up is necessary to determine if this graft will enhance the function and increase the durability of the aortic valve.

Valsalva prosthesis in aortic valve-sparing operations

Aortic valve-sparing operations have provided very good clinical outcomes. However, the absence of the sinuses of Valsalva might limit valve durability. The Gelweave Valsalva prosthesis, which presents pre-fashioned neo-sinuses, has been designed in order to avoid early leaflets deterioration. We report our results in 63 patients who underwent valve-sparing operations (reimplantation technique) using the Gelweave Valsalva graft. The main indication was ascending aorta aneurysm or annuloaortic ectasia, with or without aortic insufficiency. The operation was performed also in cases of Marfan syndrome, Bicuspid Aortic Valve (BAV), and acute Type A dissection. In-hospital mortality was of 4.7%, and two thirds were acute Type A dissection patients (P=0.01). There were no late deaths. Three years freedom from grade 3-4 AI and freedom from late aortic valve replacement were 91.7+/-4.3% and 93.8+/-5.1%, respectively. Aortic valve-sparing operations show good results in patients electively operated for aortic root ectasia. Aortic cusps repair may lead to late failure. Even if the Gelweave Valsalva prosthesis is easy to implant and it also reproduces pseudosinuses, a long-term follow up is necessary to determine if this graft may reduce leaflets deterioration.

A technique to reposition sinotubular junction in aortic valve reimplantation procedures with the De Paulis Valsalva graft

Sinotubular junction reconstruction in reimplantation type of valve-sparing aortic procedure can present some problem when a Valsalva graft is used. Since in the Valsalva graft the sinotubular junction height is predetermined, correct matching with native commissures height can be difficult. We propose a method by which it is possible to create a new sinotubular junction in Valsalva graft without altering its original configuration.

The ideal theoretical graft oversizing in valve-sparing aortic operations with a standard tubular or a Valsalva graft

We sought to determine, by a mathematical model, the ideal theoretical degree of ascending aortic graft oversizing needed to obtain normal sinuses dimension in the reimplantation type of valve-sparing aortic operations. To define a normal-range value, size of sinuses of Valsalva was conventionally expressed as the area surrounding fully opened aortic cusps, the so-called beyond leaflets area (BLA), and measured in 50 healthy subjects. A mathematical relationship between aortic annulus diameter, aortic sinuses diameter and resulting BLA was defined. By simulating intra-operative scenarios, the effect of different degrees of a standard or Valsalva graft oversizing on BLA extension was tested. The same degree of graft oversizing resulted in a bigger beyond leaflets area for the Valsalva graft than for a standard graft. Oversizing degrees exceeding +7mm for a standard graft and +3mm for the Valsalva graft resulted in a beyond leaflets area over normal limits. Results were expressed in a visual form as two different normograms, one for the standard graft and one for the Valsalva graft. A less pronounced graft oversizing is needed to achieve normal-range sinuses size when using a Valsalva graft, the ideal theoretical graft oversizing was +7mm for a standard graft and +3mm for the Valsalva graft, our normograms can be helpful in selecting a proper graft size when performing a valve-sparing aortic procedure.

A simple method to adapt the height of the sinotubular junction of the De Paulis Valsalva graft to the height of the patient's sinuses in David reimplantation procedure

De Paulis and associated introduced a new aortic root conduit for valve-sparing operation. The use of this prosthesis for David I (reimplantation) procedure occasionally may be problematic when the top of the commissures, do not match the new sinotubular junction of the graft. We propose a simple method that allows to create a new sinotubular junction at the desired level in the skirt portion of the Valsalva prosthesis.

The Valsalva graft in aortic valve repair and replacement

Presentation of the use of the new Valsalva graft that incorporates sinuses of Valsalva: its use is mostly recommended for the reimplantation type of valve sparing procedure where it combines the advantages of proper anatomical reconstruction with those of annular stabilization. Its advantages when used in the remodeling technique or in a classical Bentall procedure are also shown. The problem of graft sizing and of proper geometrical reconstruction of the aortic root are addressed.