Use Of Fine-needle Aspiration Biopsy Research Articles

Diagnosis of Metastatic Malignant Melanoma by Fine Needle Aspiration Biopsy: A Clinical and Pathologic Correlation of 298 Cases<xref ref-type="fn" rid="FN2">2</xref>

Fine needle aspiration biopsies (FNABs) from 298 lesions in patients with suspected metastatic melanoma were studied. The results were correlated either with histopathologic diagnoses on resected lesions or with prolonged clinical follow-up. Of 165 malignant aspirates, 160 were confirmed either by surgical resection (65 cases) or by an appropriate clinical course (95 cases). Of the 107 benign lesions with adequate follow-up, 73 were confirmed as benign. There were 25 false negatives: 19 were inadequate samples, and 6 were presumed failures of needle localization. No interpretative errors were identified. Although 3 cases of FNAB-diagnosed malignant melanoma could not be confirmed by surgical biopsy, the cytologic findings were typical of malignant melanoma. Clinical follow-up, however, suggested that the cytologic diagnosis was in error. One case of a second unrelated malignancy (an adenocarcinoma of the lung) was correctly diagnosed with the use of FNAB. Because of its high degree of accuracy, FNAB has proved useful in the differential diagnosis of subcutaneous nodules, enlarged lymph nodes, and lung nodules.

Fine-needle aspiration biopsy of the thyroid. Superior diagnostic tool.

Fine-needle aspiration biopsy of thyroid nodules is an easily performed office procedure that has the highest sensitivity and specificity and the lowest cost of all evaluation methods. Interpretation requires an experienced cytologist or endocrinologist, or both. Patient acceptance has been high. With use of fine-needle aspiration biopsy, many unnecessary operations have been avoided.

Fine‐needle aspiration biopsy: Efficacy in the diagnosis of head and neck sarcoidosis

The authors report the usefulness of fine-needle aspiration biopsy to establish the diagnosis of sarcoidosis in patients with palpable disease in the head and neck areas. Aspiration biopsy proved to be a simple and quick method for establishing this diagnosis in the eight cases reported in this series. Interpretation of cytologic smears with identification of typical sarcoid-like granulomas proved to be quite easy. No complications occurred secondary to use of this technique.

Usefulness of Fine-needle Aspiration Biopsy of Spleen in Diagnosis of Sarcoidosis

Fine-needle aspiration biopsy of the spleen was carried out in 557 patients. In 381 cases, the aspiration was performed because of suspected sarcoidosis. The sensitivity of the technique was 59 percent and the specificity 97 percent. The cytologic picture of the spleen was abnormal in 184 patients with sarcoidosis and in seven patients with extrinsic allergic alveolitis. No major complications occurred. The method provides a simple, safe, quick, and reliable way of producing evidence of a granulomatous process in patients with suspected sarcoidosis. The biopsy method can be used with advantage before application of more invasive techniques.

Obstetrics-Gynecology

In considering advances of the past year in obstetrics and gynecology, three areas of clinical significance have been selected. They are (1) the use of ritodrine hydrochloride in preterm labor, (2) the increasing recognition of<i>Chlamydia trachomatis</i>as a significant pathogen in the female reproductive organs, and (3) the use of fine-needle aspiration biopsy in lieu of the more traditional methods of tissue sampling. Of course, these events did not occur during just the past year, but they gained considerable attention during 1980. <h3>Ritodrine</h3> Prematurity is the leading cause of perinatal morbidity and mortality. It has been estimated that about 8% of liveborn infants in the United States weigh less than 2,500 g. Many cases are the result of "accidents" of pregnancy such as abruptio placentae, premature rupture of the membranes, and placenta previa. A large number, however, are caused by labor that begins prematurely without known cause. It is

Transthoracic needle aspiration biopsy: accuracy of cytologic typing of malignant neoplasms.

A correlation was made between the cytologic and the histologic diagnoses of 162 patients who underwent transthoracic fine-needle aspiration biopsy in whom histologic proof of the nature of the aspirated lesion was available. Compared to the histologic diagnosis, the specific cell-type cytologic diagnosis was usually in agreement when reported as squamous cell carcinoma (86%), adenocarcinoma (86%), or small cell anaplastic carcinoma(86%). In patients with a known extrapulmonary primary malignant neoplasm, the cytologic specimen was extremely helpful in identifying a new pulmonary lesion as metastatic rather than as a primary lesion in the lung. These results warrant the more extensive use of fine-needle aspiration biopsy in patients with pulmonary neoplasms in whom the specific cell type of the malignant neoplasm has important implications in therapy.

The use of fine-needle aspiration biopsy for the diagnosis of hepatic steatosis in rats

The usefulness and safety of the fine-needle aspiration biopsy (FNAB) technique for the study of liver cell changes were evaluated in rats. Repeated punctures of the same liver lobe (40 punctures in 10 weeks) caused small necroses and hemorrhages which were rapidly organized without significant distortion of the liver structure. Fatty change induced by a high fat diet was recognized in cytological smears stained with Fettrot 7B, and its progression with time monitored. The cytologie findings correlated well with histopathological and biochemical changes observed in the same animals.