Safe Use Research Articles

Copaiba Essential Oil: Composition, Therapeutic Actions, and Methods of Use for Health and Well-Being

Essential oils, known for their complex mixture of bioactive compounds, have long been used in traditional medicine and have shown potential in treating various diseases, including cancer. Recent studies highlight their anticancer properties, such as cytotoxic, antiproliferative, and antimetastatic effects. Essential oils contain molecules like terpenes and phenylpropanoids, which induce apoptosis in cancer cells by interfering with cellular signaling pathways. For instance, frankincense oil induces programmed cell death in breast cancer cells, while compounds like curcumin and thymol inhibit the proliferation of colorectal cancer cells. Additionally, certain essential oils prevent metastasis by inhibiting the migration and invasion of cancer cells. Despite promising preclinical results, the effectiveness and safety of essential oils in cancer treatment require further validation through human clinical trials. This review discusses the potential of essential oils as complementary therapies in cancer treatment, emphasizing the need for cautious application under professional supervision due to their concentrated nature and possible adverse effects. The therapeutic promise of essential oils lies in their ability to induce apoptosis, inhibit cell proliferation, and prevent metastasis, underscoring the importance of rigorous research to ensure their safe and effective use in oncology.

Poly(butylene succinate) Microparticles Prepared Through Green Suspension Polycondensations

AbstractThe demand for sustainable polymer particles production is growing, driven by the need for efficient, biocompatible, and biodegradable materials. In this context, the present study explores the production of poly(butylene succinate) (PBS) particles in a single step using a green heterogeneous suspension process, using vegetable oil as the suspending medium. Particularly, the effects of oil type (soybean, corn, sunflower), dispersed phase holdup (10–30 wt.%), stabilizers (Span 20, Span 80, Tween 80, Brij 52, Brij 93, Igepal‐co‐520, Polyglycerol polyricinoleate (PGPR)), reaction time (1–5 h), and temperature (100–160 °C) on the suspension polymerization are investigated. Results indicate that particle size and shape are influenced by the vegetable oil and stabilizer. Additionally, it is shown that the particle size distribution is affected by the use of a sonicator, allowing the manufacture of even smaller microsized particles. Based on the results, a 30 wt.% holdup in corn oil with a blend of surfactants can be recommended, producing spherical particles with an average diameter of 100 µm. Moreover, higher reaction temperatures (160 °C) and longer reaction times (5 h) positively impacted the molar mass of the obtained particles. Finally, cytotoxicity tests using Bone Marrow‐Derived Macrophages cells confirmed the safe use of PBS microparticles at concentrations up to 1000 µg mL⁻¹

Cow Dung Liquid Mulch Improves Maize Yields: Beneficial Microorganisms Are Enriched and Environmental Risks Are Reduced and Nutrient Cycling Is Promoted

Cow dung liquid mulch (CDLM), which uses cow dung as a raw material, has a good degradability and is a potential alternative to traditional plastic agricultural mulch, but there is a lack of research on the effects of CDLM on rhizosphere soil physicochemical properties, rhizosphere soil microbial functions, and crop yields. In this study, the link between maize yield, environmental factors, and functional genes as well as the responses of microbial community functions to CDLM and polyethylene mulch (PE) were studied using metagenomic sequencing. Functional annotation was also performed on clusters of orthologous groups of proteins, the Kyoto Encyclopedia of Genes and Genomes, and carbohydrate-active enzyme sequencing data. The results showed that CDLM significantly increased maize yield by 30.9% compared to CK while maintaining lower soil microplastic levels. CDLM promotes the enrichment of beneficial microorganisms such as Mycolicibacterium and Pseudomonas. The relative abundance of functional genes related to microbial metabolism, soil element cycling pathways, and organic matter degradation was significantly higher in CDLM than in CK. Microbial functional genes were positively correlated with maize yield and environmental factors such as soil nutrients. These results suggested that CDLM can improve maize yield by enriching beneficial microorganisms, reducing rhizosphere soil environmental risks, and enhancing rhizosphere soil microbial function. Rhizosphere soil nutrients and microbial functional genes together mediated the positive response of maize yield to CDLM. This study can provide a scientific basis and data support for the safe use of mulch in the future.

Nano Fertilizers: Revolutionizing Agriculture for a Sustainable Future

Nanotechnology, one of the advanced fields of study, is currently the focus of contemporary science and one of the most important ones in physics, chemistry, agriculture, and other fields. Nanotechnology provides superior quality, environmental safety, biological support, and financial stability as an environmentally sound substitute for traditional agriculture. Utilizing nanoparticles (NPs) in agriculture has introduced recently; examples like biosynthesis, the use of nanopesticides and fertilizers, improving biological function, and reducing heavy metal toxicity and abiotic stress. To focus on safe use and positive response of nano-particles, more research is required. There are gaps in the food supply compare to food production, which get worse over time due to rising food demands and nutrient depletion. Environmental degradation, changes in soil ecology, and problems with agricultural output are all brought on by synthetic fertilizer inputs. Adapting advanced agriculture technolgy for a sustainable future will be the main topic of this review.

Development of the headspace gas chromatography-tandem mass spectrometry method for ethylene oxide and ethylene chlorohydrin residue in medical devices.

Ethylene oxide (EO) sterilization is commonly employed for the sterilization of medical devices and has a very high market share. However, EO and its metabolite ethylene chlorohydrin (ECH) are toxic to humans. In compliance with the classification and residue limits of medical devices defined by ISO 10993-7, our study established two extraction methods for the testing of EO and ECH. The first method involves simulated-use extraction using water as the extraction solvent. While the second, exhaustive extraction, directly extracts sample through headspace sampling analysis. Gas chromatography-tandem mass spectrometry in multiple reaction monitoring mode was utilized, requiring only 16 min. Then, the developed method was applied to assess 10 commercially available medical devices sterilized by EO. In simulated-use extraction, calibration curves were evaluated in the range of 1-100 and 5-500 μg for EO and ECH, respectively (r > 0.999). Inter-day recoveries ranged from 85.0% to 95.2% and from 94.8% to 102.4%. In exhaustive extraction, calibration curves spanned 0.5-50 and 2-200 μg for EO and ECH, respectively (r > 0.999). Inter-day recoveries ranged from 101.6% to 102.1% for EO and from 98.1% to 102.2% for ECH. After analysis of the 10 commercially available medical devices, two cotton swabs were found to have ECH of 35.1 and 28.4μg per device, and four medical devices were found to have EO with concentration below the limit of quantification. Meanwhile, we found that the EO internal standard (propylene oxide) recommended by ISO 10993-7 had interference problems with other similar substances and was not suitable as an internal standard for EO. This study offers a sensitive and straightforward analytical approach to EO and ECH residues in a variety of medical devices. In addition, the results show that the EO or ECH content of these types of medical devices in our study falls below the regulatory limits, therefore instilling confidence among consumers regarding their safe use.

Isolation and Characterization of Canine Adipose-Derived Mesenchymal Stromal Cells: Considerations in Translation from Laboratory to Clinic.

In allogeneic MSC implantation, the cells are isolated from a donor different from the recipient. When tested, allogeneic MSCs have several advantages over autologous ones: faster cell growth, sufficient cell concentration, and readily available cells for clinics. To ensure the safe and efficient use of allogeneic MSCs in clinics, the MSCs need to be first tested in vitro. With this study, we paved the way by addressing the in vitro aspects of canine adipose-derived MSCs, considering the limited studies on the clinical use of canine cells. We isolated cAD-MSCs from canine falciform ligament fat and evaluated their viability and proliferation using an MTS assay. Then, we characterized the MSC-specific antigens using immunophenotyping and immunofluorescence and demonstrated their potential for in vitro differentiation. Moreover, we established shipping and cryobanking procedures to lead the study to become an off-the-shelf therapy. During expansion, the cells demonstrated a linear increase in cell numbers, confirming their proliferation quantitatively. The cells showed viability before and after cryopreservation, demonstrating that cell viability can be preserved. From a clinical perspective, the established shipping conditions demonstrated that the cells retain their viability for up to 48 h. This study lays the groundwork for the potential use of allogeneic cAD-MSCs in clinical applications.

Risks Analysis and Internet Perception Among Spanish University Students

<p style="text-align:justify"><span style="font-size:9.0pt">Digital competence entails the healthy, safe, and responsible use of digital technologies to take engage in society, to learn, work and to interact with. However, the use of digital devices is not exempt of risks. The objectives of this study were to analyze the mediating effect of fear of missing out (FoMO) on phubbing and nomophobia, and to explore the perception of the use of Internet-connected devices among 522 Spanish university students, with an average age of 27.11 years. The 80.8% are women and 68.2% study degrees related with Educational Sciences. A mixed-methods approach was used, combining bivariate correlation with structural equation modelling (SEM), and qualitative content analysis. SEM analysis revealed that FoMO had a significant effect on nomophobia and phubbing. Qualitative content analysis underlined that the time spent, problematic use, and sense of dependence were the main concerns for participants. It is emphasized that the plethora of ICT opportunities exposes individuals to risk contexts, necessitating media education to mitigate psychological and social consequences stemming from Internet risks.</span></p>

Modelling and optimizing the impact resistance of engineered cementitious composites with Multiwalled carbon nanotubes using response surface methodology

Engineered Cementitious Composites (ECC) are highly regarded in construction owing to their tensile ductility and crack control capabilities, making them suitable for various structural applications. The accumulation of multi-walled carbon nanotubes (MWCNTs) further enhances their mechanical properties. However, there’s a significant knowledge gap concerning MWCNTs-ECC impact resistance. The objective of this study is to tackle the challenges associated with evaluating, optimizing, and predicting MWCNTs-ECC impact resistance to ensure its safe and widespread use in critical infrastructure by applying response surface methodology (RSM). Moreover, the 13 mixtures of ECC combined with several quantities of PVA fiber and MWCNTs as input elements were utilized to calculate the first (E1) and final (E2) impact energies. The findings demonstrated that the MWCNTs-ECC combinations’ impact resistance improved as the input ingredient concentrations increased. Besides, the optimum E1 and E2 of ECC combined with 1% of PVA fiber were noted by 1398 Joules and 12,956 Joules at 0.065% of MWCNTs on 28 days respectively. Furthermore, Response prediction models for E1 and E2 were created, and after being validated with an analysis of variance (ANOVA), it was determined that they had high R2 readings of 99.30% and 99.07%, correspondingly. The optimization process produced an ideal number of input variables for MWCNTs and PVA fiber, respectively, of 0.066% and 1%, with a desirability value of 100%. Moreover, it is recommended that the usage of 0.066% of MWCNTs in ECC combined with 1.0–1.50% PVA fiber provides optimum results for the construction industry.

A Review on Nanotechnological Approaches for the Management of Stored Insect-Pests: Present Scenario and Future Prospects

Approximately 10% to 30% of the stored agricultural produce is damaged out of which 26% is due to insect-pest infestation thus seriously impacting the food security. The infestation also leads to loss of quality and thereby affecting the overall profitability. In absence of enough storage space, usually farmers dispose-off their produce immediately after harvest and thus do not get remunerative prices. For those opting for storage, physical and chemical methods are in vogue to manage the storage insect-pests. Fumigation with chemical pesticides such as methyl bromide and aluminium phosphide is a common method, though it has its own health and environmental risks. Inhalation of phosphine gas released when aluminium phosphide is used could seriously affect human animal health, sometimes leading to deaths. Thus for using these fumigants, strict supervision of government recognized experts is required. Due to their wide usage, some insect-pests have developed resistance against these molecules. Nanotechnology has created numerous new opportunities in agriculture and allied sectors. Insecticide formulations based on nanotechnology could be a viable alternative to toxic chemicals like aluminium phosphide to manage storage insect-pests. In recent years, a variety of formulations including solid nanopesticides, controlled-release formulations, nano-emulsions, and nano-suspensions have been developed possessing different modes of actions and applications. Their small size is a significant advantage because it provides higher insect-body surface area coverage and thus enhanced efficacy as compared to traditional pesticides. Aside from their small size, they are reported to be safe for non-target beneficial organisms. Nano-pesticides can thus prove as effective and eco-friendly alternatives for insect pest control in storage. However, there is a need to establish their safety on the human and animal ecosystems to rule out their ecological hazards over time. In absence of such information, nanopesticides will not be widely accepted despite their other beneficial effects. In this article, an effort is made to review the current status of nano-formulations for the management of storage-insect-pests, the research and extension gaps and ways to bridge the gaps to ensure safe use of the technology for efficient management of postharvest storage losses.

Adolescent-Reported Changes in Provider Behavior Following Pediatrician Training in Stimulant Diversion Prevention: Results From a Cluster Randomized Controlled Trial.

To test whether pediatrician training leads to provider utilization of stimulant diversion prevention strategies as reported by adolescent patients with ADHD. Pediatric practices received a stimulant diversion prevention workshop (SDP) or continued treatment-as-usual (TAU) in a cluster-randomized controlled trial. Surveys were completed by 341 stimulant-treated patients at baseline and three follow-up assessments. In intent-to-treat analyses of patient reports, SDP adolescents reported more provider use of diversion prevention strategies compared to TAU. They also reported more parent-patient communication about diversion. Provider satisfaction with the training was strong. Pediatricians can make use of clinical practice strategies for the prevention of stimulant diversion following a 1-hr training; findings are novel given their reliance on confidential patient report of provider behavior and increase confidence in the results. Coupled with the positive provider satisfaction ratings, results suggest that this brief workshop may be an option for concerned providers that also has the effect of increasing discussion at home about safe use of stimulants.

Review on Acute Reactions while Administration of Intravenous Medications

The most common invasive procedure that patients admitted to hospital wards likely undergo is intravenous (IV) access. Medications through IV fluid injection is administered to up to 80% of hospital patients. Certain medications, such as phenytoin, vancomycin, ampicillin/sulbactam combinations, steroids, and cefotaxime, might result in abrupt responses when intravenous fluids are administered. antibiotics such as mitomycin, daunorubicin, dactinomycin, and doxorubicin. Antineoplastic drugs such as methotrexate, cyclophosphamide, etoposide, vinorelbine, carboplatin, oxaliplatin, paclitaxel, and epirubicin. Dopamine, noradrenaline, amiodarone, adrenaline, and pituitrin are examples of inotropic substances. Bevacizumab, Cisplatin, Heparin, Glucocorticoids, Tamoxifen, Testosterone, and Antidepressants. When administering IV medication, Clinical Pharmacist are crucial in identifying and reporting drugs that cause acute responses. Clinical Pharmacist can be involved because they can be crucial in ensuring safe pharmaceutical use in hospitals.

Tips for percutaneous nephrolithotomy for transplant kidney stone

IntroductionThe management of urinary tract stones, particularly de novo kidney allograft stones, presents unique challenges for kidney transplant recipients because of their prevalence and specific clinical considerations. Here, we describe a case in which percutaneous nephrolithotomy was successfully used to fragment a large kidney allograft stone ≥20 mm in size.Case presentationA 57‐year‐old woman who underwent ureteroureterostomy post simultaneous pancreas–kidney transplantation presented with gross hematuria after 15 years. Computed tomography revealed a 23‐mm stone in the transplanted kidney. Initial attempts at endoscopic combined intrarenal surgery were changed to percutaneous nephrolithotomy because of poor ureter mobility and tortuosity. Stone fragmentation was achieved using pneumatic and ultrasonic lithotripsy. A second procedure using Swiss LithoClast® Trilogy enabled complete stone clearance and ureteral stent placement.ConclusionBy understanding the peculiarities of the percutaneous approach, we demonstrated the safe and effective use of a pneumatic and ultrasonic lithotripter for kidney allograft stone fragmentation.

Safe Use of Screen Time Among Adolescents: A Randomized Controlled Study of the Efficacy of Yoga

Safe Use of Screen Time Among Adolescents: A Randomized Controlled Study of the Efficacy of Yoga

Incidence of Benzodiazepine Use and Misuse Among Adults in Selected Areas of Bangladesh

Background: Benzodiazepines (BDZ) are widely prescribed for anxiety and insomnia in Bangladesh, but their misuse has become a major public health concern. Objective: The aim of this study was to identify the incidence and patterns of use and misuse of BDZ in Bangladesh, and to explore the factors contributing to their misuse. Methodology: A cross-sectional study, including 368 current BDZ users, was conducted in the department of Pharmacology, Monno Medical College, Manikganj, during January, 2021 to December, 2022. The participants were selected randomly. Structured questionnaires were used to include participants’ personal information, drug use characteristics, physiological and psychological effects of drugs usage. Verbal consent was taken from each of the respondents. Results: In this study, 268(72.83%) of the participants were male, where 157(42.66%) were from the age group 31-40 years and 139(37.77%) were single. Among the study population, 51(13.86%) were students, 79(21.47%) had monthly family income above 50,000 Bangladeshi taka. Many of the participants reported that they used BDZs to relieve stress/pressure (108, 29.35%), followed by 95(25.82%) to manage insomnia, 79(21.47%) for relieving anxiety, depression and to get pleasure and others The mostly used drug was clonazepam (112, 30.43%), followed by diazepam (108, 29.35%) and others. Most of the users were influenced by friends (115, 31.25%). The common side effects of using BDZs were confusion (47, 12.77%), fatigue (45, 12.22%), drowsiness (37, 10.05%), and others. The mostly experienced withdrawal effect was headache (86, 23.28%), followed by insomnia (59, 16.25%), confusion (50, 13.48%) and others. Conclusion: BZDs were widely used in selected areas of Bangladesh with high incidence of misuse. The most common reason of misuse was self-medication. Increasing awareness program should be taken for safe and effective use of the drug. Journal of Monno Medical College December, 2023; 9 (2):68-72

Medication management during risk of dehydration: A qualitative study among elderly patients with impaired renal function and informal caregivers

Background Patients with impaired renal function are at an increased risk of dehydration due to vomiting, diarrhoea or fever (so-called sick days). Temporary medication adjustment during sick days is necessary and current initiatives and information materials for patients are available. However, the knowledge, experiences and information needs of patients and informal caregivers about sick day guidance are unknown. Aim To gain insight into the understanding of safe medication use during periods of dehydration risk in elderly patients with impaired renal function and their informal caregivers. Design and setting Qualitative interview study with patients with impaired renal function and unrelated informal caregivers from three community pharmacies in the Netherlands. Method The interviews were conducted by telephone or live by two researchers in November 2020–September 2021 and audiotaped and transcribed verbatim. The coding of transcripts was performed deductively and inductively in Nvivo 12, a thematic analysis was applied. Results In total 12 patients and 11 unrelated informal caregivers were included. Three main themes were derived from the interview guide and subthemes emerged from the transcripts. The included patients and informal caregivers had limited knowledge about medication management during sick days. In contrast to patients, informal caregivers seemed interested in a medication management protocol for sick days. Conclusion Patients with impaired renal function and informal caregivers have little knowledge about and experience with dehydration and safe use of medication during sick days. General practitioners and pharmacists should involve the care network, including informal caregivers, when implementing sick day guidance.

Physics-informed deep convolutional network for combined sea ice concentration and velocity prediction

Accurate prediction of short-term fluctuations in Arctic sea ice is important for safe use of Arctic shipping routes. While deep-learning models can improve the accuracy of sea-ice predictions, the accuracy and predictability of short-term sea-ice conditions are limited in most purely data-driven deep-learning models that consider a single aspect of sea ice, without considering the physical variation law between several sea ice factors. We propose dual-task prediction models for sea ice concentration (SIC) and sea ice velocity (SIV), and incorporate a loss function that simultaneously addresses dynamic constraints of SIC and SIV into each model, based on dynamics terms in the sea ice control equation. Comparative experiments are performed to determine which model structure best performs at predicting SIC and SIV. We report a dual-task branching structure to be more suitable for predicting SIC and SIV, and a post-decoder branch network structure to best predict SIC and SIV. Adding a sea ice dynamics equation to the loss function improves the model fit with dynamics law, improving the predictability and prediction accuracy of SIC and SIV.

ORIENTAÇÃO FARMACÊUTICA E OS RISCOS DA SEMAGLUTIDA: NAVEGANDO COM SEGURANÇA NA PERDA DE PESO

The overall objective is to understand the adverse effects and dangers associated with the inappropriate use of these medications, as well as the importance of professional guidance for safe weight loss. The methodology adopted was an integrative literature review, with searches in the LILACS and SCIELO databases, between 2019 and 2024, using terms such as “use”, “medication” and “weight loss”. Inclusion criteria were articles relevant to the topic, published in Portuguese and available in full. Editorials, reports and bulletins were excluded. In development, the study addresses obesity as a multifactorial condition, commonly associated with an energy imbalance. It discusses the use of semaglutide, a medication used off-label for weight loss, highlighting its mechanisms of action, efficacy and side effects. It is concluded that, despite the benefits in weight reduction, the indiscriminate use of semaglutide without medical guidance can lead to serious complications. Pharmacists play an essential role in guiding patients on the safe use of these medications, promoting an integrated and safe approach to weight loss. The study emphasizes the importance of responsible and informed practices for managing obesity, preventing risks to physical and mental health.

Population pharmacokinetics and pharmacodynamics of L-asparaginase and its impact on the development of pancreatitis and hypersensitivity reactions in children with leukemia under treatment

L-asparaginase (L-Asp) is an essential enzyme in the treatment of patients with Acute Lymphoblastic Leukemia (ALL), commonly associated with adverse events (AE). Knowing the pharmacokinetic and pharmacodynamic (PK/PD) parameters of L-Asp as well as its relationship with the development of AE is an important strategy in the search to improve the efficacy and safety of the treatment. Seventy-four children with ALL that were being treated with L-Asp, were included. One to three blood samples were randomly obtained from each patient, at times from 0 to 30 hours, until completing a total of 211 samples. The L-Asp activity and the Asparagine (Asp) concentration were quantified, in addition, the presence of anti-L-Asp antibodies (Anb) was determined. A population PK/PD model of L-Asp was developed to determine the association of covariates with PK/PD parameters. The presence of Anb was associated with the increase in L-Asp clearance (CL) and with the decrease of volume of distribution 1 (V1). On the other hand, female sex was significantly associated with the increase of V1, while the age from 1 to 6 years was significantly associated with the increase of V1. The presence of Anb as well as the female sex were related to the increase IC50 (concentration-needed to deplete-50% of Asp). Patients who presented Asp depletion before the first 24 hours after administration presented pancreatitis, this could be a risk marker. Significant results were found in this study, use of these results may contribute to the safe and effective use of L-Asp.

Agomelatine in pediatric patients with moderate to severe major depressive disorder: an open-label extension study.

Major depressive disorder (MDD) in young people is a common psychiatric disorder, but treatment options are limited. Agomelatine has demonstrated short-term efficacy and safety in pediatric patients. We report here the results of a 92-week open-label extension (OLE). The international, multicenter, double-blind, study randomized 400 patients (80 children, 320 adolescents) with moderate-to-severe MDD to one of four treatment groups: agomelatine 10mg (n = 102), agomelatine 25mg (n = 95), placebo (n = 103), and fluoxetine 10-20mg (n = 100). After 12weeks, patients who could benefit from treatment continuation were offered entry into an optional OLE during which they received agomelatine 10 or 25mg for a further 92weeks. A total of 339 patients (271 adolescents) entered the OLE. Treatment groups considered for the OLE analysis reflected those received in the double-blind and OLE periods: agomelatine (10 or 25mg) in both (ago/ago, n = 170); placebo then agomelatine 10-25mg (pcb/ago, n = 85); or fluoxetine then agomelatine 10-25mg (fluox/ago, n = 84). Mean age (± SD) at entry into the double-blind phase (Week 0) was 13.6 ± 2.7years and 61.9% were female. Mean changes in Children's Depression Rating Scale revised (CDRS-R) raw total score from Week 12 to last post-Week 12 value in the three groups were - 16.3 ± 12.2 (ago/ago), - 18.9 ± 16.1 (pcb/ago), and - 16.1 ± 15.5 (fluox/ago), reflecting the difference in efficacy between treatments during the double-blind period, and heterogeneity at W12 between the treatment groups. Adverse events considered related to treatment occurred in 14.5% of patients: 15.3% ago/ago, 16.5% pcb/ago, and 10.7% fluox/ago. Three patients (all adolescents) experienced treatment-related severe adverse events: two treated with ago/ago and one treated with pcb/ago. Among the adolescents, one treatment-related severe adverse event in a patient in the pcb/ago group led to study withdrawal. Agomelatine was associated with continuous improvement in depressive symptoms without unexpected safety signals. These findings support the safe use of agomelatine in a pediatric population with moderate-to-severe MDD for up to 104weeks.Trial registration No: EUDRACT No. 2015-002181-23.

Quantitative Advantages of Corrosion Sensing Using Fluorescence, Microscopy, and Single-Molecule Detection.

The corrosion of metals and alloys is a fundamental issue in modern society. Understanding the mechanisms that cause and prevent corrosion is integral to saving millions of dollars each year and to ensure the safe use of infrastructure subject to the hazardous degrading effects of corrosion. Despite this, corrosion detection techniques have lacked precise, quantitative information, with industries taking a top-down, macroscale approach to analyzing corrosion with tests that span months to years and yield qualitative information. Fluorescence, a well-established optical method, can fill the niche of early-stage, quantitative corrosion detection and can be employed for both bulk and localized testing over time. The latter, fluorescence microscopy, can be pushed to greater levels of detail with single-molecule microscopy, achieving nanometer spatial and subsecond temporal resolutions of corrosion that allow for the extraction of dynamic information and kinetics. This review will present how fluorescence microscopy can provide researchers with a molecular view into the chemical mechanisms of corrosion at interfaces and allow for faster, quantitative studies of how to detect and prevent corrosion.