Clinical pathways are developed by clinicians but used for various purposes in the US health care system. Pathways were designed to result in the best possible clinical and financial outcomes. Real-world care management involves multiple clinicians, administrators, and other organizations responsible for benefits administration outside of direct clinical care. As a result, there are many different uses for clinical pathways. This pilot study provides a brief literature review on users, uses, and a recent electronic survey to determine how users use pathways along with their feedback around their value. Key findings from this limited sample indicate a variety of uses for pathways reported primarily by nurses, nursing staff, or practice administration. This preliminary effort aids in documenting the value and real-world use of care pathways in the diverse care provider marketplace that plans to be studied in a larger survey with updated questions. This area of clinical pathways remains an important effort to better understand and provide a guide for those working in this growing field of clinical-economic work in the health care system.