Objective: The purpose of this study was to determine the relationship between the stress experienced by adolescents in relation to their academic expectations and the use of nonprescription products. Material and Methods: An analytical cross-sectional research design was employed. Simple randomization was utilized to select the participants who included 707 students from science, social science, vocational, and Anatolian high schools. The participants completed the Adolescent Information Form, Academic Expectations Stress Inventory (AESI), and Multidimensional Scale of Perceived Social Support (MSPSS). Results: No significant statistical relationship was found in any of the subscales of the MSPSS and AESI (p>0.05). Multivariate logistic regression analysis revealed usage of red/green prescribed medication, nonprescription medication, and medication acquired from friends was high among those participants who were unable to talk about their problems to their families. Considering the relationship between environmental factors and adolescent's nonprescription medication usage; presence of friends using medication, vitamin supplements, and nonprescription medication product use was found to increase the risk of nonprescription medication usage among the participants. Furthermore, usage of nonprescription medication was high among those who attended science and Anatolian high schools. Conclusion: Approximately 10% of adolescents was consumed tea/coffee above the daily safe dose. The use of products in the immediate vicinity was increased the risk of vitamin supplement use. Test anxiety was increased the risk of usage of nonprescription medication. School type and grade level were effective for adolescents usage of nonprescription drugs, drugs acquired from friends and take vitamin supplements.